El Dezenfektanlarının Antibakteriyel ve İrritasyon Etkinliklerinin Araştırılması

Yıl 2022, , 128 - 132, 07.05.2022

Ali Metin Güzel , Erhan Mendi

https://doi.org/10.31590/ejosat.1010038

Öz

Çalışmamızda el dezenfektanları için formüle edilmiş sıvı ve sprey ürünlerinin virüs, bakteri, mantar üzerindeki etkinlikleri ile iritasyon değerlendirilmesindeki sonuçları paylaşılmıştır. Pandemi sonrasında yüksek dozlarda dezenfektan kullanımı ile birlikte cilt üzerindeki tahribatlar incelendiğinde, bakterisidal ve virsüdal etkinliklerin yanı sıra en büyük parametre olarak iritasyon kriteri üzerinde durulmuştur. Bu makale alkol bazlı el dezenfektanlarının doğru bir formülasyonla ciltte iritasyon sorununu minumum değerlere indirdiğini göstermektedir.

Anahtar Kelimeler

Dezenfektan, Pandemi, İrritasyon.

Destekleyen Kurum

BETA KİMYA SANAYİ VE TİCARET A.Ş.

Proje Numarası

YU2001-DEZ/SI

Teşekkür

Dezenfektan ürün grubu ile hiyjen sektörüne giriş yapmamızı ve öz sermayesini kullanarak tüm belgelendirme süreçlerini hızlı bir şekilde yönetmemizi sağlayan Beta Kimya yönetim kuruluna ve süreçte desteğini esirgemeyen Ar-Ge müdürü Erhan Mendi Bey’e teşekkür ederiz.

Investigation of Antibacterial and Irritation Effectiveness for Hand Disinfectants

Öz

In our study, liquid and spray hand disinfectant products have been investigated to effectiveness of viruses, bacteria, fungi and the results of irritation evaluation are shared. After the pandemic, high doses of disinfectant consumption that cause of over the destruction on skin in addition to bactericidal and viral activities, criterion was emphasized as the biggest parameter. This article shows that alcohol-based hand disinfectant can minimize skin irritation with the right formulation.

Anahtar Kelimeler

Disinfectant, Pandemic, Irritation.

Proje Numarası

YU2001-DEZ/SI

Kaynakça

• COVID-19 Coronavirus 2019-nCov Statics Update: 239,037,231 Cases and 4,872,802 Deaths. [(accessed on 12 Oct 2021)]; Available online: https://www.worldometers.info/coronavirus/.
• Kampf G., Todt D., Pfaender S., Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J. Hosp. Infect. 2020;104:246–251. doi: 10.1016/j.jhin.2020.01.022.
• Van Doremalen N., Bushmaker T., Morris D.H., Holbrook M.G., Gamble A., Williamson B.N., Tamin A., Harcourt J.L., Thornburg N.J., Gerber S.I., et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N. Engl. J. Med. 2020;382:1564–1567. doi: 10.1056/NEJMc2004973.
• Seto W.H., Tsang D., Yung R.W.H., Ching T.Y., Ng T.K., Ho M., Ho L.M., Peiris J.S.M. Advisors of Expert SARS group of Hospital Authority Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS) Lancet. 2003;361:1519–1520. doi: 10.1016/S0140-6736(03)13168-6.
• Hand Sanitizer Use Out and About Available online: https://www.cdc.gov/handwashing/hand-sanitizer-use.html.
• Dixit A., Pandey P., Mahajan R., Dhasmana D.C. Alcohol based hand sanitizers: Assurance and apprehensions revisited. Res. J. Pharm. Biol. Chem. Sci. 2014;5:558–563.
• Deshpande A, Fox J, Wong KK, Cadnum JL, Sankar T, Jencson A, Schramm S, Fraser TG, Donskey CJ, Gordon S. Comparative Antimicrobial Efficacy of Two Hand Sanitizers in Intensive Care Units Common Areas: A Randomized, Controlled Trial. Infect Control Hosp Epidemiol. 2018 Mar;39(3):267-271.
• Rai H, Knighton S, Zabarsky TF, Donskey CJ. Comparison of ethanol hand sanitizer versus moist towelette packets for mealtime patient hand hygiene. Am J Infect Control. 2017 Sep 01;45(9):1033-1034.
• Pedersen L.K., Held E., Johansen J.D. and Agner T., Short term effects of alcohol-based disinfectant and detergent on skin irritation, Contact Dermatitis 2005: 52: 82-87.
• Löffler H., Kampf G., Hand disinfection: How irritant are alcohols?, Journal of Hospital Infection (2008) 70 (S1) 44-48.
• Prado M.F., Coelho A.C.C, Brito J.P.B, Ferreira D.O., Junior A.W., Silva Menecucci C., Queiroz A.B., Garcia L.B., Cardoso C.L., Tognim M.C.B, Antimicrobial efficacy of alcohol-based hand gels with a 30-s application, Letters in Applied Microbiology ISSN 0266-8254.
• Chang S.C., Li W.C., Huang K.Y., Huang Y.C., Chiu C.H., Hsieh Y.C., Kuo C.Y., Shih S.R., Lin T.Y., Efficacy of alcohols and alcohol-based hand disinfectants against human enterovirus 71, Journal of Hospital Infection 83 (2013) 288-293.
• Privatdozent S.S.S., Unger A., Berger M., Ebner W., Hauer T., Ten to fifteen seconds are needed for complete skin coverage with alcoholic hand disinfectant, Infection Control & Hospital Epidemiology (2020), 1-2 doi: 10.1017/ice.2019.382
• Kampf G., Löffler H., Dermatological aspects of a successful introduction and continuation of alcohol-based hand rubs for hygienic hand disinfection, Journal of Hospital Infection (2003) 55, 1-7.
• Kumar S., Das A., Hand sanitizers: Science and rationale, Indian Journal of Dermatology, Venereology and Leprology March 2021. Doi: 10.25259/IJDVL_598_20.
• Picheansathian W., A systematic review on the effectiveness of alcohol-based solutions for hand hygiene, International Journal of Nursing Practice 2004; 10: 3-9.