Green Chemistry Metrics: Calculation of Green Chemistry Metrics of Biginelli Compounds Synthesized Under the Catalyst and Catalyst-Free Reaction Conditions

Abstract

In this study, green chemistry metrics such as atom economy, environmental factor (E-factor), carbon efficieny, reaction mass efficiency and mass intensity of synthesized twelve Biginelli compounds under MgBr2 or MgCl2·6H2O catalysed, solvent-free and catalyst-free with solvent (EtOH) conditions were calculated. All green chemistry metrics results were compared and the best green chemistry reaction conditions and green metrics for twelve Biginelli compounds were determined.

Keywords

• Green metrics,Atom economy,Environmental factor (E-factor),Carbon efficiency,Reaction mass efficiency,Biginelli Reaction

Yeşil Kimya Ölçümleri: Katalizörlü ve Katalizörsüz Reaksiyon Şartlarında Sentezlenmiş Biginelli Bileşiklerinin Yeşil Kimya Ölçümlerinin Hesaplanması

Öz

Bu çalışmada, MgBr2 veya MgCl2·6H2O katalizlenmiş, çözücüsüz ve katalizörsüz, çözücülü (EtOH) reaksiyon şartlarında sentezlenmiş oniki adet Biginelli bileşiğinin atom ekonomisi, çevresel etki faktörü (E-faktör), karbon etkinliği, reaksiyon kütle etkinliği ve kütle yoğunluğu gibi yeşil kimya ölçümleri hesaplanmıştır. Tüm yeşil kimya ölçüm sonuçları karşılaştırılmış ve oniki Biginelli bileşiği için en iyi yeşil kimya reaksiyon şartları ve yeşil ölçümler belirlenmiştir.

Anahtar Kelimeler

• Yeşil Kimya Ölçümleri,Atom Ekonomisi,Çevresel Etki Faktörü,Karbon Etkinliği,Reaksiyon Kütle etkinliği,Biginelli Reaksiyonu

Kaynakça

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