Yıl 2019, Cilt , Sayı 16, Sayfalar 533 - 543 2019-08-31

Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?

Lütfiye Ekici [1] , Havva Polat [2]


Akkermansia muciniphila, insan fekal örneğinden yakın tarihte izole edilen ve dikkatleri üzerine çeken gastrointestinal mikrobiyota üyelerinden biridir. Bilimsel çalışmalardan elde edilen sonuçlar, Akkermansia muciniphila’ nın diyabet ve obezite gibi günümüzün önemli sağlık sorunlarına karşı alternatif bir çözüm olabileceğini düşündürmektedir. Akkermansia’ nın bu etkisi, müsini degrade edebilme yeteneği sayesinde mukus kalınlığını ve bağırsak bariyer bütünlüğünü pozitif şekilde modüle ederek metabolik endotoksemiyi azaltmasından kaynaklanmaktadır. Akkermansia insülin salgılanmasını uyaran GLP-1 hormonunu sekresyonunu arttırarak da etkili olmaktadır. İnsanların beslenme alışkanlıkları, alkol tüketimi, metmorfin ve antibiyotik tedavileri bağırsaktaki Akkermansia yoğunluğunu birebir etkileyen faktörler arasındadır. Bireylerin diyetlerinde yer alan gıdaların polifenol, probiyotik ve prebiyotik içeriklerinin de Akkermansia sayısı üzerine etkilerinin olduğu belirlenmiştir. Bu derlemenin amacı, Akkermansia muciniphila’ nın bağırsak florasındaki önemi ve aktivitesi üzerine etkili faktörlerin değerlendirilmesidir. Ayrıca, Akkermansia muciniphila’ nın obezite ve diyabet üzerine etki mekanizması konusundaki literatür verilerinin derlenmesi hedeflenmiştir.

Gastrointestinal mikrobiyota, Akkermansia muciniphila, Diyabetes mellitus
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Birincil Dil tr
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Orcid: 0000-0002-2216-9128
Yazar: Lütfiye Ekici (Sorumlu Yazar)
Kurum: Erciyes Üniversitesi
Ülke: Turkey


Orcid: 0000-0002-7872-3810
Yazar: Havva Polat
Kurum: ERCİYES ÜNİVERSİTESİ
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 31 Ağustos 2019

Bibtex @derleme { ejosat563713, journal = {Avrupa Bilim ve Teknoloji Dergisi}, issn = {}, eissn = {2148-2683}, address = {}, publisher = {Osman SAĞDIÇ}, year = {2019}, volume = {}, pages = {533 - 543}, doi = {10.31590/ejosat.563713}, title = {Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?}, key = {cite}, author = {Ekici, Lütfiye and Polat, Havva} }
APA Ekici, L , Polat, H . (2019). Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?. Avrupa Bilim ve Teknoloji Dergisi , (16) , 533-543 . DOI: 10.31590/ejosat.563713
MLA Ekici, L , Polat, H . "Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?". Avrupa Bilim ve Teknoloji Dergisi (2019 ): 533-543 <https://dergipark.org.tr/tr/pub/ejosat/issue/45333/563713>
Chicago Ekici, L , Polat, H . "Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?". Avrupa Bilim ve Teknoloji Dergisi (2019 ): 533-543
RIS TY - JOUR T1 - Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi? AU - Lütfiye Ekici , Havva Polat Y1 - 2019 PY - 2019 N1 - doi: 10.31590/ejosat.563713 DO - 10.31590/ejosat.563713 T2 - Avrupa Bilim ve Teknoloji Dergisi JF - Journal JO - JOR SP - 533 EP - 543 VL - IS - 16 SN - -2148-2683 M3 - doi: 10.31590/ejosat.563713 UR - https://doi.org/10.31590/ejosat.563713 Y2 - 2019 ER -
EndNote %0 Avrupa Bilim ve Teknoloji Dergisi Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi? %A Lütfiye Ekici , Havva Polat %T Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi? %D 2019 %J Avrupa Bilim ve Teknoloji Dergisi %P -2148-2683 %V %N 16 %R doi: 10.31590/ejosat.563713 %U 10.31590/ejosat.563713
ISNAD Ekici, Lütfiye , Polat, Havva . "Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?". Avrupa Bilim ve Teknoloji Dergisi / 16 (Ağustos 2019): 533-543 . https://doi.org/10.31590/ejosat.563713
AMA Ekici L , Polat H . Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?. Avrupa Bilim ve Teknoloji Dergisi. 2019; (16): 533-543.
Vancouver Ekici L , Polat H . Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?. Avrupa Bilim ve Teknoloji Dergisi. 2019; (16): 543-533.