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Akkermansia muciniphila: Could It Be a New Alternative to Prevention from Obesity and Diabetes?

Yıl 2019, Sayı: 16, 533 - 543, 31.08.2019
https://doi.org/10.31590/ejosat.563713

Öz

Akkermansia muciniphila is one of the members of the gastrointestinal microbiota which has been recently isolated from the human fecal sample and attracted attention. The results obtained from scientific studies suggest that Akkermansia muciniphila may be an alternative solution to today's important health problems such as diabetes and obesity. This effect of Akkermansia result from the reduction of metabolic endotoxemia by modulating the mucus thickness and intestinal barrier integrity positively by the ability to degrade the mucin. Akkermansia is also effective by increasing the secretion of GLP-1 which stimulates insulin secretion. Nutritional habits of people, alcohol consumption, metmorphine and antibiotic treatments are among the factors that directly affect the density of Akkermansia in the intestine. It was determined that the polyphenol, probiotic and prebiotic contents of the foods included in the diets of individuals had effects on the number of Akkermansia. The aim of this review is to evaluate the factors affecting the importance and activity of Akkermansia muciniphila in intestinal flora. In addition, it is aimed to compile the literature data on mechanism of the action of Akkermansia muciniphila on obesity and diabetes.

Kaynakça

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Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?

Yıl 2019, Sayı: 16, 533 - 543, 31.08.2019
https://doi.org/10.31590/ejosat.563713

Öz

Akkermansia muciniphila, insan fekal örneğinden yakın tarihte izole edilen ve
dikkatleri üzerine çeken gastrointestinal mikrobiyota üyelerinden biridir.
Bilimsel çalışmalardan elde edilen sonuçlar, Akkermansia muciniphila’ nın diyabet ve obezite gibi günümüzün
önemli sağlık sorunlarına karşı alternatif bir çözüm olabileceğini
düşündürmektedir. Akkermansia’ nın bu
etkisi, müsini degrade edebilme yeteneği sayesinde mukus kalınlığını ve
bağırsak bariyer bütünlüğünü pozitif şekilde modüle ederek metabolik
endotoksemiyi azaltmasından kaynaklanmaktadır. Akkermansia insülin salgılanmasını uyaran GLP-1 hormonunu
sekresyonunu arttırarak da etkili olmaktadır. İnsanların beslenme
alışkanlıkları, alkol tüketimi, metmorfin ve antibiyotik tedavileri
bağırsaktaki Akkermansia yoğunluğunu
birebir etkileyen faktörler arasındadır. Bireylerin diyetlerinde yer alan
gıdaların polifenol, probiyotik ve prebiyotik içeriklerinin de Akkermansia sayısı üzerine etkilerinin
olduğu belirlenmiştir. Bu derlemenin amacı, Akkermansia
muciniphila
’ nın bağırsak florasındaki önemi ve aktivitesi üzerine etkili
faktörlerin değerlendirilmesidir. Ayrıca,
Akkermansia muciniphila
’ nın obezite ve diyabet üzerine etki mekanizması
konusundaki literatür verilerinin derlenmesi hedeflenmiştir.

Kaynakça

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  • Neyrinck, A. M., Etxeberria, U., Taminiau, B., Daube, G., Van Hul, M., Everard, A., Cani, P.D., Bindels L. B.,& Delzenne, N. M. (2017). Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota. Molecular Nutrition and Food Research, 61(1), 1–12. https://doi.org/10.1002/mnfr.201500899
  • Onkamo, P., Väänänen, S., Karvonen, M., & Tuomilehto, J. (1999). Worldwide increase in incidence of type I diabetes - The analysis of the data on published incidence trends. Diabetologia, 42(12), 1395–1403. https://doi.org/10.1007/s001250051309
  • Org, E., Parks, B.W., Joo, J.W., Emert, B., Schwartzman, W., Kang, E.Y., Mehrabian, M., Pan, C., Knight, R., Gunsalus, R., Drake, T.A., Eskin, E., Lusis A.J. (2015). Genetic and environmental control of host-gut microbiota interactions. Genome Research, 25(10), 1558–1569. https://doi.org/10.1101/gr.194118.115
  • Ottman, N., Geerlings, S. Y., Aalvink, S., Vos, W. M. De, & Belzer, C. (2017). The discovery of Akkermansia muciniphila has opened new avenues for the use of this. Best Practice & Research Clinical Gastroenterology. https://doi.org/10.1016/j.bpg.2017.10.001
  • Overton, H.A., Babbs, A.J., Doel, S.M., Fyfe, M.C., Gardner, L.S., Griffin, G., Jackson, H.C., Procter, M.J., Rasamison, C.M., Tang-Christensen, M., Widdowson, P.S., Williams, G.M.,& Reynet, C.(2006). Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metabolism, 3(3), 167–175. https://doi.org/10.1016/j.cmet.2006.02.004
  • Overton, H.A., Fyfe, M.C., Reynet, C. (2008) . GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity. British Journal of Pharmacology 153 (1), 76-81. https://doi.org/10.1038/sj.bjp.0707529
  • Özden, A. (2006). Sağlıklı Yaşam İçin Yararlı Dost Bakteriler. Türk Gastroentoloji Vakfı Yayınları, Ankara.
  • Özyurt, V. H. & Ötles, S.(2014). Properties of probiotics and encapsulated probiotics in food. Acta Scientiarum Polonorum, Technologia Alimentaria, 13(4), 413-424. https://doi.org/10.17306/J.AFS.2014.4.8
  • Parkar, S. G., Stevenson, D. E., & Skinner, M. A. (2008). The potential influence of fruit polyphenols on colonic microflora and human gut health. International Journal of Food Microbiology, 124(3), 295–298. https://doi.org/10.1016/j.ijfoodmicro.2008.03.017
  • Pérez-Cobas, A. E., Gosalbes, M. J., Friedrichs, A., Knecht, H., Artacho, A., Eismann, K., Otto, W., Rojo, D., Bargiela, R., von Bergen, M., Neulinger, S.C., Däumer, C., Heinsen, F.A., Latorre, A., Barbas, C., Seifert, J., dos Santos, V.M., Ott, S.J., Ferrer, M.,& Moya, A.. (2014). Gut microbiota disturbance during antibiotic therapy: A multi-omic approach. Gut Microbes, 5(1), 64–70. https://doi.org/10.4161/gmic.27128
  • Reid, G., Younes, J. A., Van Der Mei, H. C., Gloor, G. B., Knight, R., & Busscher, H. J. (2011). Microbiota restoration: Natural and supplemented recovery of human microbial communities. Nature Reviews Microbiology, 9(1), 27–38. https://doi.org/10.1038/nrmicro2473
  • Reid, D. T., Eller, L. K., Nettleton, J. E., & Reimer, R. A. (2016). Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats. European Journal of Nutrition, 55(8), 2399–2409. https://doi.org/10.1007/s00394-015-1047-2
  • Roberfroid, M., Gibson, G., Hoyles, L., McCartney, A., Rastall, R., Rowland, I., Wolvers, D., Watzl, B., Szajewska, H., Stahl, B., Guarner, F., Respondek, F., Whelan, K., Coxam, V., Davicco, M.J., Léotoing, L., Wittrant, Y., Delzenne, N.M., Cani, P.D., & Ne, A. (2010). Prebiotic effects: Metabolic and health benefits. British Journal of Nutrition, 104(2), 1–63. https://doi.org/10.1038/159869b0
  • Rodes, L., Khan, A., Paul, A., Coussa, C. M., Marinescu, D., Tomaro D. C., Shao,W., Kahouli, I.,& Prakash, S. (2013). Effect of probiotics Lactobacillus and Bifidobacterium on gut-derived lipopolysaccharides and inflammatory cytokines: an in vitro study using a human colonic microbiota model. Journal of Microbiology and Biotechnology, 23(4), 518–526.
  • Roopchand, D. E., Carmody, R. N., Kuhn, P., Moskal, K., Rojas-Silva, P., Turnbaugh, P. J., & Raskin, I. (2015). Dietary polyphenols promote growth of the gut bacterium Akkermansia muciniphila and attenuate high fat diet-induced metabolic syndrome. Diabetes, 64(8), 2847–2858.
  • Santacruz, A., Collado, M., García-Valdés, L., Segura, M., Martín-Lagos, J., Anjos, T., Martí-Romero, M., Lopez, R.M., Florido, J., Campoy, C., Sanz, Y. (2010). Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women. British Journal of Nutrition, 104(1), 83–92. https://doi.org/10.1017/S0007114510000176
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  • Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010). Microbiota and SCFA in lean and overweight healthy subjects. Obesity, 18(1), 190–195. https://doi.org/10.1038/oby.2009.167
  • Shin, N. R., Lee, J. C., Lee, H. Y., Kim, M. S., Whon, T. W., Lee, M. S., & Bae, J. W. (2014). An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut, 63(5), 727–735. https://doi.org/10.1136/gutjnl-2012-303839
  • Tailford, L. E., Crost, E. H., Kavanaugh, D., & Juge, N. (2015). Mucin glycan foraging in the human gut microbiome. Frontiers in Genetics, 6(81). https://doi.org/10.3389/fgene.2015.00081
  • Tannock, G. W., Munro, K., Harmsen, H. J. M., Welling, G. W.,& Smart, J. (2000). Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. Applied and Environmental Microbiology, 66(6), 2578–2588. https://doi.org/10.1128/aem.66.6.2578-2588.2000
  • Tekin, T., Çiçek, B.,& Konyalıgil, N. (2018). İntestinal mikrobiyota ve obezite ilişkisi. Sağlık Bilimleri Dergisi, 27, 95–99.
  • Yetkin, İ., Satış, H., & Satış, N. K. (2017). Bağırsak mikrobiyotasının insülin direnci, diabetes mellitus ve obezite ile ilişkisi. Türkiye Diyabet ve Obezite Dergisi, 1: 1-8.
  • Yılmaz, K., & Altındiş, M. (2017). Sindirim sistemi mikrobiyotasi ve fekal transplantasyon. Nobel Medicus, 13(1), 9–15.
  • Zhang, X., Shen, D., Fang, Z., Jie, Z., Qiu, X., Zhang, C., … Ji, L. (2013). Human gut microbiota changes reveal the progression of glucose intolerance. PLoS ONE, 8(8), e71108. https://doi.org/10.1371/journal.pone.0071108
  • Zhou, Z. Y., Ren, L. W., Zhan, P., Yang, H. Y., Chai, D. D.,& Yu, Z. W. (2016). Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling. Acta Pharmacologica Sinica, 37(8), 1063–1075. https://doi.org/10.1038/aps.2016.21
  • Zhou, K. (2017). Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies. Journal of Functional Foods, 33, 194–201. https://doi.org/10.1016/j.jff.2017.03.045
Toplam 94 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Lütfiye Ekici 0000-0002-2216-9128

Havva Polat 0000-0002-7872-3810

Yayımlanma Tarihi 31 Ağustos 2019
Yayımlandığı Sayı Yıl 2019 Sayı: 16

Kaynak Göster

APA Ekici, L., & Polat, H. (2019). Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?. Avrupa Bilim Ve Teknoloji Dergisi(16), 533-543. https://doi.org/10.31590/ejosat.563713