Yıl 2019, Cilt , Sayı 16, Sayfalar 701 - 706 2019-08-31

Yeni p-alkilaminofenol Bileşiklerinin Sentezi ve Antimikrobiyal ve Antioksidan Aktivitelerinin Araştırılması
Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity

Yeliz Ulaş [1] , Ahmet İsmail Özkan [2] , Veysel Tolan [3]


Alkilaminofenoller antikanser aktivitelerine sahip iyi bilinen organik yapılardır. Bu çalışmada, yüksek verimlerle petasis reaksiyonuyla  bir seri (4,5,6)  alkilaminofenol bileşiği sentezlendi. Sentezlenen bileşikler 'H-NMR ve 13C-NMR ile karakterize edildi. Ardından,bu bileşiklerin antimikrobiyal ve antioksidan aktivitelerini incelendi. Elde edilen bileşikler, Gram pozitif ve Gram negatif bakterilere karşı test edildi. 4 nolu bileşiğin , 10 mg / mL konsantrasyonda antimikrobiyal aktivite gösterirken, 6 nolu bileşiğin, S. aureus'ta aktivite gösterdiği görüldü. Fenolik bileşikler proksimal ve antioksidan aktivitelerinden dolayı dikkat çekici yapılardır. Alkilaminofenoller fenolik yapıya sahip olduklarından antioksidan aktiviteleri de araştırılmıştır. Diyabete, kalp hastalığına ve kansere karşı yüksek antioksidan kapasiteye sahip ilaç aktif maddeleri;  ilk kez sentezlenmiştir.

Alkylaminophenols are synthetic derivatives well known for their anticancer activity. In this work, we report the antimicrobial and antioxidant activity of such compounds. A series (4,5,6) of alkylaminophenol compounds were prepared with very high yields by Petasis reaction. Synthesized compounds were characterized by 1H-NMR and 13C-NMR. The obtained compounds were tested against Gram-positive and Gram-negative bacteria. The compound 4 showed antimicrobial activity at a concentration of 10 mg/mL, while the 6 compound showed activity on S. aureus. Phenolic compounds have attracted attention due to their proximal and antioxidant activities. Since alkylaminophenols have phenolic structure, their antioxidant activity has been investigated. Thus, drug-active substances with high antioxidant capacity against diabetes, heart disease, and cancer were synthesized.

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Birincil Dil en
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Orcid: 0000-0003-2038-1851
Yazar: Yeliz Ulaş (Sorumlu Yazar)
Kurum: Bursa Uludag University, Faculty of Art and Science, Department of Chemistry
Ülke: Turkey


Orcid: 0000-0002-4511-2386
Yazar: Ahmet İsmail Özkan

Orcid: 0000-0003-0172-6957
Yazar: Veysel Tolan

Destekleyen Kurum Bursa Uludag University Scientific Research Projects Unit
Proje Numarası KUAP(F)-2015/22
Tarihler

Yayımlanma Tarihi : 31 Ağustos 2019

Bibtex @araştırma makalesi { ejosat582483, journal = {Avrupa Bilim ve Teknoloji Dergisi}, issn = {}, eissn = {2148-2683}, address = {}, publisher = {Osman SAĞDIÇ}, year = {2019}, volume = {}, pages = {701 - 706}, doi = {10.31590/ejosat.582483}, title = {Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity}, key = {cite}, author = {Ulaş, Yeliz and Özkan, Ahmet İsmail and Tolan, Veysel} }
APA Ulaş, Y , Özkan, A , Tolan, V . (2019). Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity. Avrupa Bilim ve Teknoloji Dergisi , (16) , 701-706 . DOI: 10.31590/ejosat.582483
MLA Ulaş, Y , Özkan, A , Tolan, V . "Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity". Avrupa Bilim ve Teknoloji Dergisi (2019 ): 701-706 <https://dergipark.org.tr/tr/pub/ejosat/issue/45333/582483>
Chicago Ulaş, Y , Özkan, A , Tolan, V . "Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity". Avrupa Bilim ve Teknoloji Dergisi (2019 ): 701-706
RIS TY - JOUR T1 - Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity AU - Yeliz Ulaş , Ahmet İsmail Özkan , Veysel Tolan Y1 - 2019 PY - 2019 N1 - doi: 10.31590/ejosat.582483 DO - 10.31590/ejosat.582483 T2 - Avrupa Bilim ve Teknoloji Dergisi JF - Journal JO - JOR SP - 701 EP - 706 VL - IS - 16 SN - -2148-2683 M3 - doi: 10.31590/ejosat.582483 UR - https://doi.org/10.31590/ejosat.582483 Y2 - 2019 ER -
EndNote %0 Avrupa Bilim ve Teknoloji Dergisi Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity %A Yeliz Ulaş , Ahmet İsmail Özkan , Veysel Tolan %T Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity %D 2019 %J Avrupa Bilim ve Teknoloji Dergisi %P -2148-2683 %V %N 16 %R doi: 10.31590/ejosat.582483 %U 10.31590/ejosat.582483
ISNAD Ulaş, Yeliz , Özkan, Ahmet İsmail , Tolan, Veysel . "Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity". Avrupa Bilim ve Teknoloji Dergisi / 16 (Ağustos 2019): 701-706 . https://doi.org/10.31590/ejosat.582483
AMA Ulaş Y , Özkan A , Tolan V . Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity. Avrupa Bilim ve Teknoloji Dergisi. 2019; (16): 701-706.
Vancouver Ulaş Y , Özkan A , Tolan V . Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity. Avrupa Bilim ve Teknoloji Dergisi. 2019; (16): 706-701.