Yıl 2019, Cilt , Sayı 17, Sayfalar 522 - 529 2019-12-31

Chromatographic Applications in Medicine

Ozlem Coskun [1] , Özlem Öztopuz [2]


Son yıllarda kromatografi, bir ilacın ve metabolitlerinin tanımlanması ve nicelleştirilmesi için en önemli analitik yöntemlerden biri olarak medikal alanda tercih edilmektedir.  İlaçların özellikleri ve etkileşim tiplerine göre ayırmak için çeşitli kromatografik teknikler geliştirilmiştir.  Bu teknikler, Yüksek performanslı afinite kromatografisi (HPAC), Hücre membran kromatografisi (CMC), Karma modlu kromatografi (MMC),Sıvı kromatografisi (LC) klinik öncesi ve klinik çalışmalarda ilaçların biyoanalizi için farmasötik amaçlı kullanılmaktadır. Kromatografinin hızlı ve hassas analitik yöntemler geliştirilmesindeki başarısı, ilaçların AR-GE'deki farmakokinetik özelliklerinin araştırılmasında da üstün özgünlük ve duyarlılık sağlar. Kişiselleştirilmiş tıpta ilaçların dozajı ve etkisi kişiden kişiye nasıl değişiklik gösterdiği önemlidir. Kromotografi, ilaç-protein bağlanmasının analizi ve klinik veya farmasötik numunelerin incelenmesinde umut verici bir teknik haline gelmiştir.

Kromatografi, biyofarmasötik
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Orcid: 0000-0002-0741-5001
Yazar: Ozlem Coskun (Sorumlu Yazar)
Kurum: Çanakkale Onsekiz Mart Üniversitesi
Ülke: Turkey


Orcid: 0000-0002-1373-6311
Yazar: Özlem Öztopuz
Kurum: Çanakkale Onsekiz Mart Üniversitesi
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 31 Aralık 2019

APA Coskun, O , Öztopuz, Ö . (2019). Chromatographic Applications in Medicine. Avrupa Bilim ve Teknoloji Dergisi , (17) , 522-529 . DOI: 10.31590/ejosat.558010