Heterocyclic compounds bearing 1,2,4-triazole and 4,5-dihydro-1H-1,2,4-triazole-5-one ring show a wide spectrum of biological activity. Schiff bases have various practical applications such as dyes, textile, cosmetics, analytical reagents, water treatment products, petroleum additives, synthetic polymer products, the improvement of natural macromolecular materials like leather and paper. However, the most important application area of Schiff Bases is pharmaceutical chemistry. It is hoped that Schiff bases containing a potentially biologically active 1,2,4-triazole ring will provide useful molecules that can be used in the treatment of many diseases and drugs that can be used in the treatment of future diseases. In this regard, new 2-methoxy-6-[(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]phenyl furan-2-carboxylates (3) were obtained from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with 2-formyl-6-methoxyphenyl furan-2-carboxylate (2). Then, acetylation reactions of 3 compounds were examined and 2-methoxy-6-[(1-acetyl-3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-on-4-yl)-azomethine]phenyl furan-2-carboxylates (4) were synthesized. The structures of fourteen new compounds were characterized by IR, 1H NMR, 13C NMR and UV spectral data. Besides, in vitro antioxidant properties of the newly synthesized 3 and 4 type compounds were evaluated by three different methods (reduction power, free radical removal activity and metal chelate activity).
|Teşekkür||Bu çalışma (107T633) no’lu proje kapsamında TÜBİTAK tarafından desteklenmiştir.|
Yayımlanma Tarihi : 15 Nisan 2020
|APA||GÜRBÜZ, A , ALKAN, M , MANAP, S , GÜRSOY KOL, Ö , ÖZDEMİR, G , YÜKSEK, H . (2020). Yeni 2-Metoksi-6-[(3-alkil/aril-4,5-dihidro-1H-1,2,4-triazol-5-on-4-il)-azometin]fenil Furan-2-karboksilat Türevlerinin Sentezi ve in vitro Antioksidan Aktiviteleri. Avrupa Bilim ve Teknoloji Dergisi , (18) , 1004-1011 . DOI: 10.31590/ejosat.656126|