Nikotinik Asit ve Türevleri İle Krom (III) İyonunun Oluşturduğu Komplekslerin Kararlılıkları

Yıl 2023, Sayı: 52, 136 - 143, 15.12.2023

Mehmet Suat Aksoy

Öz

Cr(III)’ün NA, 2-ANA ve 4-ANA ile farklı mol oranlarında (1:1 ve 1:2) potansiyometrik titrasyonları yapıldı. Gerçekleşen kompleks iyon ve bileşiklerinin stokiyometrileri ve kararlılık sabitleri bulundu. Cr(III)’ün NA, 2-ANA ve 4-ANA ile CrL2+, CrL2+, CrL(OH)+ ve CrL2(OH) türü kompleks iyon ve bileşiklerini oluşturduğu saptandı.

Anahtar Kelimeler

Nikotinik asit, Krom(III), Potansiyometri, Kararlılık sabiti

Destekleyen Kurum

Bursa Uludağ Üniversitesi Bilimsel Araştırma Projeleri Birimi

Proje Numarası

UAP(F)-70

Teşekkür

UAP(F)-70 projesine maddi desteğinden dolayı Bursa Uludağ Üniversitesi Bilimsel Araştırma Projeleri Birimine teşekkür ederiz.

Stability of Complexes Formed by Chromium(III) Ion with Nicotinic Acid and Derivatives

Öz

Potentiometric titrations of Cr(III) with NA, 2-ANA and 4-ANA in different molar ratios (1:1 and 1:2) were performed. The stoichiometry and stability constants of the complex ions and compounds were found. It was determined that chromium(III) forms complex ions and compounds such as CrL2+, CrL2+, CrL(OH)+ and CrL2(OH).

Anahtar Kelimeler

Nicotinic acid, Chromium(III), Potentiometry, Formation constant.

Proje Numarası

UAP(F)-70

Kaynakça

• Aksoy M S, Özer U, 2003. Potentiometric and spectroscopic studies with chromium(III) complexes of hydroxysalicylic acid derivatives in aqueous solution. Turk. J. Chem., 27 (6): 667–673.
• Aksoy M S, Özer U, 2004. Equilibrium studies on chromium(III) complexes of salicylic acid and salicylic acid derivatives in aqueous solution. Chem. Pharm. Bull., 52 (11): 1280–1284.
• Aksoy M S, Aydın R, Türkel N, Özer U, 2005.Formation constants of chromium(III), scandium(III) and yttrium (III) complexes of some hydroxynaphthoic acids. Chem. Pharm. Bull., 53 (5): 471–475.
• Aksoy M S, 2008. Complexes of chromium(III) with 2,3-dihydroxynaphthalene-6-sulfonic acid and 4,5-dihydroxynaphthalene-2,7- disulfonic acid in aqueous solution. Chem. Pharm. Bull., 56 (6): 771- 774.
• Aksoy M S, 2009. Formation constants of chromium(III) complexes with 8-hydroxyquinoline and 8-hydroxyquinoline-5-sulfonic acid. Asian J. Chem., 21 (7):5189–5198.
• Aksoy M S, 2010. Study of the Interaction Between Chromium(III) and Hydroxamic Acids, Journal of Chemical and Engineering Data, 55(6): 2252-2256.
• Ali M A, Kadir M H, Nazimuddin M, Majumder S M M, Tarafder M T H, Khair M A, 1988. Indian J. Chem. Sect., A 27:1064.
• Aman S, Chishti K A, Mahmood F, 2018. Potential Effect of Nicotinic Acid Derivatives on Brain Monoamines in Male Albino Mice. Latin American Journal of Pharmacy, 37(11): 2185-2190.
• Bartzatt R, Grillo S L G, Grillo J D, 2007. Antibacterial activity of dipeptide constructs of acetylsalicylic acid and nicotinic acid. Drug Delivery, 14(2): 105-109.
• Chohan Z H, Rauf A, Supuran C T, 2002. Antibacterial cobalt(II), nickel(II) and zinc(II) complexes of nicotinic acid-derived Schiff- bases, Journal of Enzyme Inhibition and Medicinal Chemistry, 17(2): 101-106.
• Cotton F A, Wilkinson G, Murillo C A, and Bochmann M, 1999. Advanced Inorganic Chemistry, 6th ed. John Wiley, New York.
• Cox M, Lehninger A L, Nelson D R, 2000. Lehninger Principles of Biochemistry. 3rd Edition, New York Worth Publishers, USA, pp: 380-381.
• Fedorov B S, Fadeev M A, Blokhina S V, 2009. Synthesis and antimetastatic activity of metal complexes based on substituted pyridinecarboxylic acid amides and platinum tetrachloride. Pharmaceutical Chemistry Journal, 43(3): 134-138.
• Gonçalves M E, Abhinav J. et al., 2011. Potentiometric Titration Study of the Temperature and Ionic Strength Dependence of the Acidity Constants of Nicotinic Acid (Niacin). J. Chem. Eng. Data, 56: 2964-2970.
• Lin Y S, Chen S H, Hou W C, 2012. Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities, 132(4): 2074-2080.
• Makhmudov A A, 2020. Synthesis and Biological Activity of Sulfamido and Alkoxycarbonyl-substituted Nicotinic Acid Esters, Russian Journal of Organic Chemistry, 56(2): 246-250.
• Mansoori M H, Khatik G L and Mishra V, 2018. Synthesis and pharmacological evaluation of pyridinyl-1,3,4-oxadiazolyl-ethanone derivatives as antimicrobial, antifungal and antitubercular agents, Medicinal Chemistry Research, 27(3): 744-755.
• Marszalek D, Goldnik A, Kumorowska S, 2014. Stability of new anticonvulsant derivatives of picolinic, nicotinic, cyclocarboxylic acids in body fluids and tissues. Acta Poloniae Pharmaceutica, 71(2): 261-264.
• Morsy Abu-Youssef A M, Dey R, Gohar Y, Massoud A A, Ohrstrom L, Langer V, 2007. Inorg. Chem., 46: 5893–5903.
• Robert M S, and, Martel A E, 1989. Critical Stability Constants. Plenum Press, New York.
• Shimai T, Islam M T, Fukushi Y, Hashidoko Y, Yokosawa R, Tahara S Z, 2002. Naturforsch, 57: 323-331. Sinthupoom N, Prachayasittikul V, 2015. Nicotinic acid and derivatives as multifunctional pharmacophores for medical applications, 240(1): 1-17.