Federated Deep Learning for Brain Tumor Segmentation: Comparative Analysis of U-Net Architectures

Öz

Medical image segmentation is essential for precise diagnosis and treatment planning, particularly in brain tumor analysis where accurate boundary delineation directly impacts surgical outcomes and therapeutic decisions. However, privacy concerns and regulatory constraints limit data sharing across healthcare institutions, restricting the development of robust deep learning models that require large, diverse training datasets. We propose a federated deep learning framework that enables collaborative brain tumor segmentation model training without compromising patient data privacy. Our approach implements three U-Net architectural variants (standard U-Net, Residual U-Net, and Attention U-Net) across multi-institutional BraTS datasets (2019-2021) using the Federated Averaging algorithm. Performance evaluation on three tumor sub-regions (whole tumor, tumor core, enhancing tumor) demonstrates that federated Attention U-Net achieves Dice scores of 0.905, 0.859, and 0.811 respectively on BraTS 2021, representing only 0.8% degradation compared to centralized training while enabling privacy-preserving collaboration. Our federated approach preserves data privacy while achieving comparable accuracy to centralized methods, demonstrating comprehensive evaluation of attention-based federated learning for multi-institutional brain tumor segmentation with statistical significance validation across three consecutive challenge datasets.

Anahtar Kelimeler

• Brain tumor segmentation
• Federated learning
• Attention mechanisms
• U-Net
• Medical imaging
• Multi-institutional learning

Destekleyen Kurum

This research was supported by The Scientific and Technological Research Council of Türkiye (TÜBİTAK) under grant number 125E398 and constitutes part of the author’s master’s thesis work.

Proje Numarası

TUBİTAK Grant number 125E398

Etik Beyan

This study was conducted using publicly available and fully anonymized BraTS challenge datasets (2019–2021). Since no private or identifiable patient information was used, additional ethical approval or informed consent was not required. All data were used strictly for academic research in accordance with the relevant guidelines and regulations.

Teşekkür

The authors thank the organizers of the BraTS challenges and all participating institutions for providing the datasets that made this study possible. We also acknowledge the neuroradiologists who contributed expert annotations and the MICCAI community for maintaining the benchmarking framework. Special gratitude is extended to the institutions and colleagues who supported the development of this research.

Beyin Tümörü Segmentasyonu için Federatif Derin Öğrenme: U-Net Mimarilerinin Karşılaştırmalı Analizi

Öz

Anahtar Kelimeler

• Beyin tümörü segmentasyonu
• Federatif öğrenme
• U-Net
• Tıbbi görüntüleme
• Çok kurumlu öğrenme

Destekleyen Kurum

Bu araştırma, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK) tarafından 125E398 numaralı proje kapsamında desteklenmiştir ve yazarın yüksek lisans tezinin bir parçasını oluşturmaktadır.

Proje Numarası

TUBİTAK Grant number 125E398

Etik Beyan

Bu çalışma, kamuya açık ve tamamen anonimleştirilmiş BraTS yarışma veri setleri (2019–2021) kullanılarak gerçekleştirilmiştir. Herhangi bir kişisel veya tanımlayıcı hasta verisi kullanılmadığından ek etik kurul iznine veya bilgilendirilmiş onama ihtiyaç duyulmamıştır. Tüm veriler, ilgili etik yönergeler ve düzenlemelere uygun şekilde yalnızca akademik araştırma amacıyla kullanılmıştır.

Teşekkür

Yazarlar, bu çalışmanın gerçekleştirilmesine olanak sağlayan BraTS organizatörlerine ve veri sağlayan tüm kurumlara teşekkür eder. Ayrıca uzman nöroradyologların sağladığı doğrulama anotasyonları ve MICCAI topluluğunun sağladığı değerlendirme altyapısı için teşekkür ederiz. Çalışmanın geliştirilme sürecinde destekleyen kurumlara ve tüm meslektaşlara özel olarak teşekkür ederiz.

Kaynakça

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