Duodenal involvement of Crohn disease: case reports

Abstract

Crohn’s disease is a chronic inflammatory condition of gastrointestinal system. Duodenal involvement varies between 0,5%-5% in crohn’s disease. Steroids, azathioprine and anti-TNF drugs are effectively use in medical treatment of this condition. Surgery is a treatment option if there is stricture, fistula or failure of medical treatment.

Keywords

• Crohn,Duodenum

Crohn hastalığının duodenal tutulumu: olgu sunumları

Öz

Crohn hastalığı gastrointestinal sistemin kronik inflamatuvar bir hastalığıdır. Crohn hastalığında duodenal tutulum sıklığı %0,5-5’lerdedir. Steroid, azatiyopürin ve anti-tümör nekrozis faktör grubu ilaçlar hastalarda etkin olarak kullanılabilir. İlaç tedavisine yanıtsızlık halinde, fistül ve striktür varlığında ise tedavi cerrahidir.

Anahtar Kelimeler

• Crohn,duodenum

Kaynakça

1. Farmer RG, Whelan G, Fazio VW. Long-term follow-up of patients with Crohn’s disease. Relationship between the clinical pattern and prognosis. Gastroenterology 1985;88:1818-25.
2. Reynolds HL Jr, Stellato TA. Crohn’s disease of the foregut. Surg Clin North Am 2001;81:117-135.
3. Nugent FW, Roy MA. Duodenal Crohn’s disease: an analysis of 89 cases. Am J Gastroenterol 1989;84:249-54.
4. van Hogezand RA, Witte AM, Veenendaal RA, et al. Proximal Crohn’s disease: review of the clinicopathologic features and therapy. Inflamm Bowel Dis 2001;7:328-37.
5. Rutgeerts P, Onette E, Vantrappen G, et al. Crohn’s disease of the stomach and duodenum: a clinical study with emphasis on the value of endoscopy and endoscopic biopsies. Endoscopy 1980;12:288-94.
6. Tremaine WJ. Gastroduodenal Crohn’s disease: Medical management. Inflamy Bowel Dis;9:127-8.
7. Firth M, Prather C. Unusual gastric Crohn’s disease treated with infliximab– A case report. Am J Gastroenterol 2002;97:S190.
8. Worsey MJ, Hull T, Ryland L, Fazio V. Strictureplasty is an effective option in the operative management of duodenal Crohn’s disease. Dise Colon Rectum 1999;42:596-600.