Colonoscopic assessment results of asymptomatic first-degree relatives of patients with colorectal cancer: A single center prospective study

Yıl 2013, , - , 01.08.2013

Bilal Ergül Murat Sarıkaya Zeynal Doğan Levent Filik

https://doi.org/10.17940/endoskopi.74803

Öz

Background and Aims: First-degree relatives of colorectal cancer patients are at increased risk of developing colorectal neoplasm, and current guidelines recommend a screening colonoscopy in such individuals. The aim of this study was to evaluate the use of total colonoscopy as the screening test in asymptomatic first-degree relatives of colorectal cancer patients. Materials and Methods:Colonoscopy was performed in 80 asymptomatic individuals (52 females, 28 males; mean age 41,6±12,9 years, range 19-75 years) who had at least one first-degree relative with colorectal cancer. As inclusion criteria, subjects had to be asymptomatic, older than 40 years, or less than 10 years younger than the index case. Results:Thirty-six colorectal lesions were found in 22 individuals: 2 (5,5%) had adenocarcinomas and the remaining 20 patients had 34 polypoid lesions [19 (52,7%) low-risk adenomas, 10 (27,8%) high-risk and 5 (13,9%) hyperplasic polyps]. The procedure was generally well tolerated without complications. Conclusions:Screening colonoscopy is safe and effective to detect adenoma and adenocarcinoma among asymptomatic first-degree relatives of patients with colorectal cancer

Anahtar Kelimeler

Screening colonoscopy, first-degree relatives, colorectal cancer, polyp

Kolorektal kanserli hastaların asemptomatik birinci derece yakınlarının kolonoskopik değerlendirme sonuçları: Tek merkezli prospektif çalışma

Öz

Giriş ve Amaç:Kolorektal kanserli hastaların birinci derece akrabalarında kolorektal neoplazm gelişme riski artmıştır, mevcut kılavuzlar bu bireylerde kolonoskopik tarama yapılmasını önermektedir. Çalışmamızın amacı, kolorektal kanserli hastaların asemptomatik birinci derece yakınlarında kolonoskopik tarama sonuçlarının değerlendirmektir. Gereç ve Yöntem: En az bir birinci derece akrabasında kolorektal kanser öyküsü olan toplam 80 asemptomatik kişiye (52 kadın, 28 erkek; ortalama yaş 41,6±12,9, 19-75) kolonoskopi yapıldı. Çalışmaya alınma kriterleri olarak; asemptomatik, 40 yaşından büyük veya indeks vakadan en fazla 10 yaş küçük olması olarak belirlendi. Bulgular:Toplam 22 hastada 36 kolorektal lezyon tespit edildi: 2 hastada (%5,5) adenokarsinom ve kalan 20 hastada 34 polipoid lezyon saptandı: 19'u (52,7%) düşük riskli adenom, 10'u (27,8%) yüksek riskli adenom ve 5 (13,9%) hastada hiperplastik polip. İşlem tüm hastalarda komplikasyon olmadan çok iyi şekilde tolere edildi. Tartışma:Kolonoskopik tarama, kolorektal kanserli hastaların birinci derece yakınlarında polip ve adenokarsinom saptanmasında etkili ve güvenlidir

Anahtar Kelimeler

Kolonoskopik tarama, birinci derece akraba, kolorektal kanser, polip

Kaynakça

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