Prevalence and characterization of acute biliary pancreatitis-associated upper gastrointestinal mucosal lesions

Öz

Background and Aims:Acute pancreatitis can be associated with various up-per gastrointestinal mucosal lesions. However, their pathogenesis and clinical significance have been discussed rarely. The aim of this study was to retros-pectively investigate upper gastrointestinal mucosal lesions in relation to the prevalence of Helicobacter pylori infection in acute biliary pancreatitis.Met-hods: This study was carried out in 94 patients with acute biliary pancreati-tis and 179 control dyspeptic patients with or without gallstone disease. In all research subjects, upper gastrointestinal endoscopy was performed, and two biopsy specimens were taken from the antrum and gastric body for histologi-cal examination and Helicobacter pylori detection. Results: 71% of patients with acute biliary pancreatitis had evidence of upper gastrointestinal mucosal abnormalities. Esophagitis and peptic ulceration were more prevalent compa-red to the control groups (p

Anahtar Kelimeler

• Biliary pancreatitis, peptic ulcer disease, Helicobacter pylori

Akut biliyer pankreatit'te üst gastrointestinal mukoza lezyonlarının yaygınlığı ve karakterizasyonu

Öz

Giriş ve Amaç:Akut pankreatit'li olgularda akut pankreatite bağlı çeşitli üst gastrointestinal mukoza lezyonları görülebildiği ve akut pankreatitle ilişkili olduğu belirtilsede, bu ilişkinin patogenezi ve klinik önemi tam olarak araştırılmamış ve ortaya çıkarılmamıştır. Bu çalışmamızın amacı kliniğimizde akut biliyer pankreatit tanısı ile yatan olgularda üst gastrointestinal mukozal lezyonları saptamak ve bu lezyonlarda Helikobakter pilori prevalansını retrospektif olarak belirlemektir. Gereç ve Yöntem: Çalışmaya retrospektif ola-rak 94 akut biliyer pankreatitli ve toplam 179 safra taşı birlikteliği olan ve olmayan dispeptik olgu kontrol grubu olarak şdahil edilmiştir. Çalışmaya dahil edilen tüm vakalardan antrum ve korpustan hem Helikobakter pilori hemde mukozanın histolojik yapısını belirlemek için ikişer adet biyopsi alın-mıştı.Bulgular: Akut biliyer pankreatitli olguların %71'inde üst gastrointes-tinal mukozal lezyon saptandı. Özofajit ve peptik ülser akut biliyer pankre-atitli olgularda kontrol grubuna göre anlamlı olarak yüksek çıktı (p

Anahtar Kelimeler

• Biliyer pankreatit, peptik ülser, Helikobakter pilori

Kaynakça

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