BibTex RIS Kaynak Göster

Colonoscopic assessment results of asymptomatic first-degree relatives of patients with colorectal cancer: A single center prospective study

Yıl 2013, Cilt: 21 Sayı: 2, - , 01.08.2013
https://doi.org/10.17940/endoskopi.74803

Öz

Background and Aims: First-degree relatives of colorectal cancer patients are at increased risk of developing colorectal neoplasm, and current guidelines recommend a screening colonoscopy in such individuals. The aim of this study was to evaluate the use of total colonoscopy as the screening test in asymptomatic first-degree relatives of colorectal cancer patients. Materials and Methods:Colonoscopy was performed in 80 asymptomatic individuals (52 females, 28 males; mean age 41,6±12,9 years, range 19-75 years) who had at least one first-degree relative with colorectal cancer. As inclusion criteria, subjects had to be asymptomatic, older than 40 years, or less than 10 years younger than the index case. Results:Thirty-six colorectal lesions were found in 22 individuals: 2 (5,5%) had adenocarcinomas and the remaining 20 patients had 34 polypoid lesions [19 (52,7%) low-risk adenomas, 10 (27,8%) high-risk and 5 (13,9%) hyperplasic polyps]. The procedure was generally well tolerated without complications. Conclusions:Screening colonoscopy is safe and effective to detect adenoma and adenocarcinoma among asymptomatic first-degree relatives of patients with colorectal cancer

Kaynakça

  • Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
  • Johns LE, Houlston RS. A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol 2001; 96: 2992-3003.
  • Brenner H, Hoffmeister M, Stegmaier C, et al. Risk of progression of advanced adenoma to colorectal cancer by age and sex: estimates based on 840149 screening colonoscopies. Gut 2007; 56: 1585-9.
  • Dove-Edwin I, Sasieni P, Adams J, et al. Prevention of colorectal can- cer by colonoscopic surveillance in individuals with a family history of colorectal cancer: 16 year, prospective, follow-up study. BMJ 2005; 331: 1047-9.
  • Levin B, Lieberman DA, McFarland B, et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi- Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology 2008; 134: 1570-95.
  • Rex DK, Johnson DA, Anderson JC, et al. American College of Gastroen- terology guidelines for colorectal cancer screening 2009. Am J Gastroen- terol 2009; 104: 739-50.
  • Davila RE, Rajan E, Baron TH, et al. ASGE guideline: colorectal cancer screening and surveillance. Gastrointest Endosc 2006; 63: 546-57.
  • Maxim M, Trifan A, Stanciu C. Colonoscopic screening of asymptomatic individuals with a family history of colorectal cancer. Rev Med Chir Soc Med Nat Iasi 2010; 114: 993-7.
  • Croitoru L, Trifan A, Maxim MR, et al. Colonoscopic screening of as- ymptomatic first-degree relatives of colorectal cancer patients. Rev Med Chir Soc Med Nat Iasi 2010; 114: 683-6.
  • Puente Gutiérrez JJ, Marín Moreno MA, Domínguez Jiménez JL, et al. Effectiveness of a colonoscopic screening programme in first-degree relatives of patients with colorectal cancer. Colorectal Dis 2011; 13: e145-53.
  • Pariente A, Milan C, Lafon J, Faivre J. Colonoscopic screening in first- degree relatives of patients with ‘sporadic’ colorectal cancer: a case–con- trol study. Gastroenterology 1998; 115: 7-12.
  • Armelao F, Orlandi PG, Tasini E, et al. High uptake of colonoscopy in first-degree relatives of patients with colorectal cancer in a healthcare region: a population-based, prospective study. Endoscopy 2010; 42: 15- 21.
  • Armelao F, Paternolli C, Franceschini G, et al. Colonoscopic findings in first-degree relatives of patients with colorectal cancer: a population- based screening program. Gastrointest Endosc 2011; 73: 527-534.e2.
  • Baglietto L, Jenkins MA, Severi G, et al. Measures of familial aggregation depend on definition on family history: metaanalysis for colorectal can- cer. J Clin Epidemiol 2006; 59: 114-24.
  • Blanco GD, Cretella M, Paoluzi OA, et al. Adenoma, advanced adenoma and colorectal cancer prevalence in asymptomatic 40 to 49-year-olds with a first-degree family history of colorectal cancer. Colorectal Dis. 2013 Apr 30. [Epub ahead of print]
  • Gupta AK, Samadder J, Elliott E, et al. Prevalence of any size adenomas and advanced adenomas in 40- to 49-year-old individuals undergoing screening colonoscopy because of a family history of colorectal carci- noma in a first-degree relative. Gastrointest Endosc 2011; 74: 110-8.

Kolorektal kanserli hastaların asemptomatik birinci derece yakınlarının kolonoskopik değerlendirme sonuçları: Tek merkezli prospektif çalışma

Yıl 2013, Cilt: 21 Sayı: 2, - , 01.08.2013
https://doi.org/10.17940/endoskopi.74803

Öz

Giriş ve Amaç:Kolorektal kanserli hastaların birinci derece akrabalarında kolorektal neoplazm gelişme riski artmıştır, mevcut kılavuzlar bu bireylerde kolonoskopik tarama yapılmasını önermektedir. Çalışmamızın amacı, kolorektal kanserli hastaların asemptomatik birinci derece yakınlarında kolonoskopik tarama sonuçlarının değerlendirmektir. Gereç ve Yöntem: En az bir birinci derece akrabasında kolorektal kanser öyküsü olan toplam 80 asemptomatik kişiye (52 kadın, 28 erkek; ortalama yaş 41,6±12,9, 19-75) kolonoskopi yapıldı. Çalışmaya alınma kriterleri olarak; asemptomatik, 40 yaşından büyük veya indeks vakadan en fazla 10 yaş küçük olması olarak belirlendi. Bulgular:Toplam 22 hastada 36 kolorektal lezyon tespit edildi: 2 hastada (%5,5) adenokarsinom ve kalan 20 hastada 34 polipoid lezyon saptandı: 19'u (52,7%) düşük riskli adenom, 10'u (27,8%) yüksek riskli adenom ve 5 (13,9%) hastada hiperplastik polip. İşlem tüm hastalarda komplikasyon olmadan çok iyi şekilde tolere edildi. Tartışma:Kolonoskopik tarama, kolorektal kanserli hastaların birinci derece yakınlarında polip ve adenokarsinom saptanmasında etkili ve güvenlidir

Kaynakça

  • Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
  • Johns LE, Houlston RS. A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol 2001; 96: 2992-3003.
  • Brenner H, Hoffmeister M, Stegmaier C, et al. Risk of progression of advanced adenoma to colorectal cancer by age and sex: estimates based on 840149 screening colonoscopies. Gut 2007; 56: 1585-9.
  • Dove-Edwin I, Sasieni P, Adams J, et al. Prevention of colorectal can- cer by colonoscopic surveillance in individuals with a family history of colorectal cancer: 16 year, prospective, follow-up study. BMJ 2005; 331: 1047-9.
  • Levin B, Lieberman DA, McFarland B, et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi- Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology 2008; 134: 1570-95.
  • Rex DK, Johnson DA, Anderson JC, et al. American College of Gastroen- terology guidelines for colorectal cancer screening 2009. Am J Gastroen- terol 2009; 104: 739-50.
  • Davila RE, Rajan E, Baron TH, et al. ASGE guideline: colorectal cancer screening and surveillance. Gastrointest Endosc 2006; 63: 546-57.
  • Maxim M, Trifan A, Stanciu C. Colonoscopic screening of asymptomatic individuals with a family history of colorectal cancer. Rev Med Chir Soc Med Nat Iasi 2010; 114: 993-7.
  • Croitoru L, Trifan A, Maxim MR, et al. Colonoscopic screening of as- ymptomatic first-degree relatives of colorectal cancer patients. Rev Med Chir Soc Med Nat Iasi 2010; 114: 683-6.
  • Puente Gutiérrez JJ, Marín Moreno MA, Domínguez Jiménez JL, et al. Effectiveness of a colonoscopic screening programme in first-degree relatives of patients with colorectal cancer. Colorectal Dis 2011; 13: e145-53.
  • Pariente A, Milan C, Lafon J, Faivre J. Colonoscopic screening in first- degree relatives of patients with ‘sporadic’ colorectal cancer: a case–con- trol study. Gastroenterology 1998; 115: 7-12.
  • Armelao F, Orlandi PG, Tasini E, et al. High uptake of colonoscopy in first-degree relatives of patients with colorectal cancer in a healthcare region: a population-based, prospective study. Endoscopy 2010; 42: 15- 21.
  • Armelao F, Paternolli C, Franceschini G, et al. Colonoscopic findings in first-degree relatives of patients with colorectal cancer: a population- based screening program. Gastrointest Endosc 2011; 73: 527-534.e2.
  • Baglietto L, Jenkins MA, Severi G, et al. Measures of familial aggregation depend on definition on family history: metaanalysis for colorectal can- cer. J Clin Epidemiol 2006; 59: 114-24.
  • Blanco GD, Cretella M, Paoluzi OA, et al. Adenoma, advanced adenoma and colorectal cancer prevalence in asymptomatic 40 to 49-year-olds with a first-degree family history of colorectal cancer. Colorectal Dis. 2013 Apr 30. [Epub ahead of print]
  • Gupta AK, Samadder J, Elliott E, et al. Prevalence of any size adenomas and advanced adenomas in 40- to 49-year-old individuals undergoing screening colonoscopy because of a family history of colorectal carci- noma in a first-degree relative. Gastrointest Endosc 2011; 74: 110-8.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Bilal Ergül Bu kişi benim

Murat Sarıkaya Bu kişi benim

Zeynal Doğan Bu kişi benim

Levent Filik Bu kişi benim

Yayımlanma Tarihi 1 Ağustos 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 21 Sayı: 2

Kaynak Göster

APA Ergül, B., Sarıkaya, M., Doğan, Z., Filik, L. (2013). Kolorektal kanserli hastaların asemptomatik birinci derece yakınlarının kolonoskopik değerlendirme sonuçları: Tek merkezli prospektif çalışma. Endoskopi Gastrointestinal, 21(2). https://doi.org/10.17940/endoskopi.74803
AMA Ergül B, Sarıkaya M, Doğan Z, Filik L. Kolorektal kanserli hastaların asemptomatik birinci derece yakınlarının kolonoskopik değerlendirme sonuçları: Tek merkezli prospektif çalışma. Endoskopi Gastrointestinal. Ağustos 2013;21(2). doi:10.17940/endoskopi.74803
Chicago Ergül, Bilal, Murat Sarıkaya, Zeynal Doğan, ve Levent Filik. “Kolorektal Kanserli hastaların Asemptomatik Birinci Derece yakınlarının Kolonoskopik değerlendirme sonuçları: Tek Merkezli Prospektif çalışma”. Endoskopi Gastrointestinal 21, sy. 2 (Ağustos 2013). https://doi.org/10.17940/endoskopi.74803.
EndNote Ergül B, Sarıkaya M, Doğan Z, Filik L (01 Ağustos 2013) Kolorektal kanserli hastaların asemptomatik birinci derece yakınlarının kolonoskopik değerlendirme sonuçları: Tek merkezli prospektif çalışma. Endoskopi Gastrointestinal 21 2
IEEE B. Ergül, M. Sarıkaya, Z. Doğan, ve L. Filik, “Kolorektal kanserli hastaların asemptomatik birinci derece yakınlarının kolonoskopik değerlendirme sonuçları: Tek merkezli prospektif çalışma”, Endoskopi Gastrointestinal, c. 21, sy. 2, 2013, doi: 10.17940/endoskopi.74803.
ISNAD Ergül, Bilal vd. “Kolorektal Kanserli hastaların Asemptomatik Birinci Derece yakınlarının Kolonoskopik değerlendirme sonuçları: Tek Merkezli Prospektif çalışma”. Endoskopi Gastrointestinal 21/2 (Ağustos 2013). https://doi.org/10.17940/endoskopi.74803.
JAMA Ergül B, Sarıkaya M, Doğan Z, Filik L. Kolorektal kanserli hastaların asemptomatik birinci derece yakınlarının kolonoskopik değerlendirme sonuçları: Tek merkezli prospektif çalışma. Endoskopi Gastrointestinal. 2013;21. doi:10.17940/endoskopi.74803.
MLA Ergül, Bilal vd. “Kolorektal Kanserli hastaların Asemptomatik Birinci Derece yakınlarının Kolonoskopik değerlendirme sonuçları: Tek Merkezli Prospektif çalışma”. Endoskopi Gastrointestinal, c. 21, sy. 2, 2013, doi:10.17940/endoskopi.74803.
Vancouver Ergül B, Sarıkaya M, Doğan Z, Filik L. Kolorektal kanserli hastaların asemptomatik birinci derece yakınlarının kolonoskopik değerlendirme sonuçları: Tek merkezli prospektif çalışma. Endoskopi Gastrointestinal. 2013;21(2).