‹İnce barsak gastrointestinal stromal tümörü (GİST): Olgu sunumu

Yıl 2012, Cilt: 20 Sayı: 2, - , 01.08.2012

Adem Güler () Taylan Özgür Sezer () Varl›k Erol () Gülten Gezer () Özgür Firat () Oktay Tekefi‹n ()

https://doi.org/10.17940/endoskopi.74832

Öz

Gastrointestinal stromal tümörler, sindirim sisteminden (mide, ince barsak, mezenter, kolon, özofagus) kaynaklanan submukozal tümörlerdir. Gastrointestinal stromal tümörler en sık midede (%50-%70), ikinci sıklıkta ince barsakta (%20-%30) ve kalın barsakta ortaya çıkarlar (yaklaşık %10). Yaklaşık %50 oranında tanı konduğunda metastaz yapmış durumdadır ve en sık karaci¤er ve peritona metastaz yapar. Cerrahi, gastrointestinal stromal tümörler tanısını histolojik olarak doğrulamak için esas yöntemdir. Rezektabl gastrointestinal stromal tümörlerde cerrahi tedavideki temel hedef makroskopik olarak temiz cerrahi sınırlı rezeksiyon uygulamaktır. Bu olgu sunumunda kanlı dışkılama şikayeti ile başvuran bir hastada saptanan ince barsak gastrointestinal stromal tümörünün tanı ve tedavisini irdelemeyi amaçladık.

Anahtar Kelimeler

GİST, ince bağırsak, tedavi

Small intestine gastrointestinal stromal tumor (GIST): Case report

Öz

Gastrointestinal stromal tumors are submucosal tumors that originate from the digestive tract (stomach, small intestine, mesentery, colon, esophagus). Gastrointestinal stromal tumors appear most frequently in the stomach (50%-70%), followed by the small intestine (20%-30%) and large intestine (nearly 10%). These tumors are metastatic at the time of diagnosis. Metastases are most frequently found in the liver and peritoneum. Surgery is the main met-hod to confirm the GIST diagnosis histologically. In resectable gastrointesti-nal stromal tumors, the main goal of the surgery is to provide a macroscopi-cally clean surgical margin. In this case report, we aimed to present the diag-nostic and therapeutic methods in a small intestine tumor patient with hema-tochezia

Anahtar Kelimeler

Gastrointestinal stromal tumors, small intestine, treatment

Kaynakça

• Nishida T, Hirota S, Yanagisawa A, et al; GIST Guideline Subcommitte- e. Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version. Int J Clin Oncol 2008;13:416-30.
• Downs-Kelly E, Rubin BP. Gastrointestinal stromal tumors: Molecular mechanisms and targeted therapies. Patholog Res Int 2011;2011: 708596.
• Yang J, Du X, Lazar AJ, et al. Genetic aberrations of gastrointestinal stro- mal tumors. Cancer 2008;113:1532-43.
• Jass JR. Tumors of the small and large intestines (including the anal re- gion). In: Fletcher CDM, ed. Diagnostic histopathology of tumors. 3rd ed. Philadelphia, Pa: Churchill Livingstone Elsevier, 2007; 381-3.
• Boşoteanu M, Boşoteanu C, Deacu M, Aşchie M. Differential diagnosis of a gastric stromal tumor: case report and literature review. Rom J Morp- hol Embryol 2011;52:1361-8.
• Badalamenti G, Rodolico V, Fulfaro F, et al. Gastrointestinal stromal tu- mors (GISTs): focus on histopathological diagnosis and biomolecular fe- atures. Ann Oncol 2007;18:136-40.
• Rabin I, Chikman B, Lavy R, et al. Gastrointestinal stromal tumors: A 19 year experience. Isr Med Assoc J 2009;11:98-102.