BibTex RIS Kaynak Göster

Assessment of the frequency and severity of esophagitis in patients with gastroesophageal reflux

Yıl 2010, Cilt: 18 Sayı: 1, 1 - 4, 01.04.2010

Öz

Background and Aims: Gastroesophageal reflux patients presenting with typical symptoms are classified into two groups according to the Montreal classification as symptomatic syndromes and syndromes with esophageal injury. In our study, we aimed to identify the frequency of syndromes with esophageal injury, which include reflux esophagitis, Barrett's esophagus, peptic stricture, and esophageal adenocarcinoma, and the location and severity of esophagitis. Materials and Methods: Patients with typical reflux symptoms who were registered in the reflux outpatient clinic were evaluated. Frequency of reflux esophagitis, Barrett's esophagus, and peptic stricture together with the location and severity of esophagitis were determined in the evaluated patients. Results: In the evaluation of upper gastrointestinal endoscopy reports of 227 patients who were admitted with typical reflux symptoms to the reflux outpatient clinic of Kocaeli University Hospital, the percentage of reflux esophagitis and Barrett's esophagus were found to be 53% and 4%, respectively. Peptic stricture was seen in only one patient. Esophageal adenocarcinoma was not found. The percentages of esophagitis according to Los Angeles classification were as follows: 50% grade A, 45% Grade B, 2.5% Grade C, and 2.5% grade D. In the assessment of mucosal breaks of the distal esophagus, most were found to be at the 2, 3 and 6 o'clock positions. Conclusions: Half of the patients presenting with typical reflux symptoms have esophagitis. Ninety-five percent of patients with esophagitis are assessed as having mild esophagitis. Most of the mucosal breaks are seen at the 2, 3 and 6 o'clock positions.

Kaynakça

  • Locke GR, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 1997;112:1448-56.
  • Bor S, Mandıracıoğlu A, Kitapçıoğlu G, et al. Gastroesophageal reflux di- sease in a low-income region in Turkey. Am J Gastroenterol 2005;100: 759-65.
  • Vakil N, Zanten SV, Kahrilas P, et al. The Montreal Definition and Clas- sification of Gastroesophageal Reflux Disease: A Global Evidence-Based Consensus. Am J Gastroenterol 2006;101:1900-20.
  • Falk GW, Fennerty BF, Rothstein RI. AGA institute technical review on the use of endoscopic therapy for gastroesophageal reflux disease. Gas- troenterology 2006;131:1315-36.
  • Johnsson F, Loelsson B, Gudmundsson K, Greif L. Symptoms and en- doscopic findings in the diagnosis of gastroesophageal reflux disease. Scand J Gastroenterol 1987;22:714-8.
  • Kitapcioglu G, Mandiracioglu A, Bor S. Psychometric and methodologi- cal characteristics of a culturally adjusted gastroesophageal reflux disea- se questionnaire. Dis Esophagus 2004;17:228-34.
  • Lundell LR, Dent J, Bennet JR, et al. Endoscopic assessment of oesopha- gitis: clinical and functional correlated and further validation of the Los Angeles classification. Gut 1999;45:172-80.
  • Ronkainen J, Aro P, Storskrubb T, et al. Prevalence of Barrett’s esopha- gus in the general population: an endoscopic study. Gastroenterology 2005;129:1825-31.
  • Yılmaz N, Tuncer K, Tunçyürek M, et al. The prevalence of Barrett’s esophagus and erosive esophagitis in a tertiary referral center in Turkey. Turk J Gastroenterol 2006;17:79-83.
  • Mungan Z, Demir K, Onuk MD, et al. Characteristics of gastroesophage- al reflux disease in our country. Turk J Gastroenterol 1999;10:101-6.
  • Voutilainen M, Sipponen P, Mecklin JP, et al. Gastroesophageal reflux disease: Prevalence, clinical, endoscopic and histopathological findings in 1128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms. Digestion 2000;61:6-13.
  • Rosaida MS, Goh KL. Gastro-esophageal reflux disease, reflux oesopha- gitis and non-erosive reflux disease in a multiracial Asian population: a prospective, endoscopy based study. Eur J Gastroenterol Hepatol 2004; 16:495-501.
  • Malfertheiner P, Lind T, Willich S, et al. Prognostic influence of Barrett’s oesophagus and Helicobacter pylori infection on healing of erosive gas- trooesophageal reflux disease (GORD) and symptom resolution in non- erosive GORD: report from the ProGORD Study. Gut 2005;54;746-51.
  • Labenz J, Jaspersen D, Kulig M. et al. Risk factors for erosive esophagi- tis. A multivariate analysis based on the ProGERD study initiative. Am J Gastroenterol 2004;99:1652-6.
  • Jonaitis LV., Kiudelis G, Kupcinskas L. Characteristics of patients with erosive and nonerosive GERD in high-Helicobacter-pylori prevalence re- gion. Diseases of the Esophagus 2004;17:223-7.
  • Bayrakçı B, Kasap E, Kitapçıoğlu G, Bor S. Low prevalence of erosive esophagitis and Barrett esophagus in a tertiary referral center in Turkey. Turk J Gastroenterol 2008;19:145-51.
  • Kirchheiner J, Glatt S, Fuhr U, et al. Relative potency of proton-pump inhibitors-comparison of effects on intragastric pH. Eur J Clin Pharma- col 2009;65:19-31.
  • El-Serag HB, Graham DY, Satia JA, et al. Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am J Gastroenterol 2005;100:1243-50.
  • Edelstein ZR, Farrow DC, Bronner MP, et al. Central adiposity and risk of Barrett’s esophagus. Gastroenterology 2007;133:403-11.
  • Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann In- tern Med 2005;143:199-211.
  • Nam SY, Choi IJ, Nam BH, et al. Obesity and weight gain as risk factors for erosive oesophagitis in men. Aliment Pharm Ther 2009;29:1042-52.

Gastroözofageal reflü hastalarında özofajit sıklığının ve şiddetinin değerlendirilmesi

Yıl 2010, Cilt: 18 Sayı: 1, 1 - 4, 01.04.2010

Öz

Giriş ve Amaçlar: Pirozis ve regürjitasyon gibi tipik reflü semptomları ile başvuran hastalarda gastroözofageal reflü hastalığı Montreal sınıflamasına göre semptomatik sendromlar ve özofagusta zedelenmeyle giden sendromlar olmak üzere iki gruba ayrılmıştır Çalışmamızda tipik reflü semptomları ile gelen hastalarda; özofagusta zedelenmeyle giden sendromlar başlığı altındaki reflü özofajit, Barrett özofagusu, peptik striktür ve özofagusun adenokarsinomunun sıklığını, özofajitin şiddeti ve lokalizasyonunu belirlemeyi amaçladık. Gereç ve Yöntem: Reflü polikliniğinde kaydı bulunan tipik reflü semptomları ile başvuran olgular değerlendirildi. Değerlendirilen hastalarda reflü özofajit, Barrett özofagusu, peptik striktür ve özofagusun adenokarsinomunun sıklığı, özofajitin şiddeti ve lokalizasyonu belirlendi. Bulgular: Kocaeli Üniversitesi Reflü polikliniğine tipik reflü semptomları ile başvuran 227 hastanın üst gastrointestinal sistem raporları değerlendirildiğinde %53 reflü özofajit, %4 Barrett özofagus ve bir hastada ise peptik striktür saptandı. Özofagus adenokanseri saptanmadı. Reflü özofajitlerin %50'si Los Angeles grade A, %45'i grade B, %2,5 grade C, %2,5 grade D olarak bulundu. Özofagus distalindeki erozyone alanların lokalizasyonları incelendiğinde ise, en sık olarak saat 2, 3 ve 6 bölgesinde oldukları saptandı. Sonuç: Tipik reflü semptomları ile gelen hastaların yaklaşık yarısı reflü özofajitlidir. Özofajitli hastaların %95'i hafif özofajitli olarak değerlendirilmiştir. En sık erozyone alanlar ise saat 2, 3 ve 6 hizasında görülmektedir.

Kaynakça

  • Locke GR, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 1997;112:1448-56.
  • Bor S, Mandıracıoğlu A, Kitapçıoğlu G, et al. Gastroesophageal reflux di- sease in a low-income region in Turkey. Am J Gastroenterol 2005;100: 759-65.
  • Vakil N, Zanten SV, Kahrilas P, et al. The Montreal Definition and Clas- sification of Gastroesophageal Reflux Disease: A Global Evidence-Based Consensus. Am J Gastroenterol 2006;101:1900-20.
  • Falk GW, Fennerty BF, Rothstein RI. AGA institute technical review on the use of endoscopic therapy for gastroesophageal reflux disease. Gas- troenterology 2006;131:1315-36.
  • Johnsson F, Loelsson B, Gudmundsson K, Greif L. Symptoms and en- doscopic findings in the diagnosis of gastroesophageal reflux disease. Scand J Gastroenterol 1987;22:714-8.
  • Kitapcioglu G, Mandiracioglu A, Bor S. Psychometric and methodologi- cal characteristics of a culturally adjusted gastroesophageal reflux disea- se questionnaire. Dis Esophagus 2004;17:228-34.
  • Lundell LR, Dent J, Bennet JR, et al. Endoscopic assessment of oesopha- gitis: clinical and functional correlated and further validation of the Los Angeles classification. Gut 1999;45:172-80.
  • Ronkainen J, Aro P, Storskrubb T, et al. Prevalence of Barrett’s esopha- gus in the general population: an endoscopic study. Gastroenterology 2005;129:1825-31.
  • Yılmaz N, Tuncer K, Tunçyürek M, et al. The prevalence of Barrett’s esophagus and erosive esophagitis in a tertiary referral center in Turkey. Turk J Gastroenterol 2006;17:79-83.
  • Mungan Z, Demir K, Onuk MD, et al. Characteristics of gastroesophage- al reflux disease in our country. Turk J Gastroenterol 1999;10:101-6.
  • Voutilainen M, Sipponen P, Mecklin JP, et al. Gastroesophageal reflux disease: Prevalence, clinical, endoscopic and histopathological findings in 1128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms. Digestion 2000;61:6-13.
  • Rosaida MS, Goh KL. Gastro-esophageal reflux disease, reflux oesopha- gitis and non-erosive reflux disease in a multiracial Asian population: a prospective, endoscopy based study. Eur J Gastroenterol Hepatol 2004; 16:495-501.
  • Malfertheiner P, Lind T, Willich S, et al. Prognostic influence of Barrett’s oesophagus and Helicobacter pylori infection on healing of erosive gas- trooesophageal reflux disease (GORD) and symptom resolution in non- erosive GORD: report from the ProGORD Study. Gut 2005;54;746-51.
  • Labenz J, Jaspersen D, Kulig M. et al. Risk factors for erosive esophagi- tis. A multivariate analysis based on the ProGERD study initiative. Am J Gastroenterol 2004;99:1652-6.
  • Jonaitis LV., Kiudelis G, Kupcinskas L. Characteristics of patients with erosive and nonerosive GERD in high-Helicobacter-pylori prevalence re- gion. Diseases of the Esophagus 2004;17:223-7.
  • Bayrakçı B, Kasap E, Kitapçıoğlu G, Bor S. Low prevalence of erosive esophagitis and Barrett esophagus in a tertiary referral center in Turkey. Turk J Gastroenterol 2008;19:145-51.
  • Kirchheiner J, Glatt S, Fuhr U, et al. Relative potency of proton-pump inhibitors-comparison of effects on intragastric pH. Eur J Clin Pharma- col 2009;65:19-31.
  • El-Serag HB, Graham DY, Satia JA, et al. Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am J Gastroenterol 2005;100:1243-50.
  • Edelstein ZR, Farrow DC, Bronner MP, et al. Central adiposity and risk of Barrett’s esophagus. Gastroenterology 2007;133:403-11.
  • Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann In- tern Med 2005;143:199-211.
  • Nam SY, Choi IJ, Nam BH, et al. Obesity and weight gain as risk factors for erosive oesophagitis in men. Aliment Pharm Ther 2009;29:1042-52.
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Altay Çelebi Bu kişi benim

Neslihan Bozkurt Bu kişi benim

Ali Erkan Duman Bu kişi benim

Gökhan Dindar Bu kişi benim

Ömer Şentürk Bu kişi benim

Sadettin Hülagü Bu kişi benim

Yayımlanma Tarihi 1 Nisan 2010
Yayımlandığı Sayı Yıl 2010 Cilt: 18 Sayı: 1

Kaynak Göster

APA Çelebi, A., Bozkurt, N., Duman, A. E., Dindar, G., vd. (2010). Gastroözofageal reflü hastalarında özofajit sıklığının ve şiddetinin değerlendirilmesi. Endoskopi Gastrointestinal, 18(1), 1-4.
AMA Çelebi A, Bozkurt N, Duman AE, Dindar G, Şentürk Ö, Hülagü S. Gastroözofageal reflü hastalarında özofajit sıklığının ve şiddetinin değerlendirilmesi. Endoskopi Gastrointestinal. Nisan 2010;18(1):1-4.
Chicago Çelebi, Altay, Neslihan Bozkurt, Ali Erkan Duman, Gökhan Dindar, Ömer Şentürk, ve Sadettin Hülagü. “Gastroözofageal Reflü hastalarında özofajit sıklığının Ve şiddetinin değerlendirilmesi”. Endoskopi Gastrointestinal 18, sy. 1 (Nisan 2010): 1-4.
EndNote Çelebi A, Bozkurt N, Duman AE, Dindar G, Şentürk Ö, Hülagü S (01 Nisan 2010) Gastroözofageal reflü hastalarında özofajit sıklığının ve şiddetinin değerlendirilmesi. Endoskopi Gastrointestinal 18 1 1–4.
IEEE A. Çelebi, N. Bozkurt, A. E. Duman, G. Dindar, Ö. Şentürk, ve S. Hülagü, “Gastroözofageal reflü hastalarında özofajit sıklığının ve şiddetinin değerlendirilmesi”, Endoskopi Gastrointestinal, c. 18, sy. 1, ss. 1–4, 2010.
ISNAD Çelebi, Altay vd. “Gastroözofageal Reflü hastalarında özofajit sıklığının Ve şiddetinin değerlendirilmesi”. Endoskopi Gastrointestinal 18/1 (Nisan 2010), 1-4.
JAMA Çelebi A, Bozkurt N, Duman AE, Dindar G, Şentürk Ö, Hülagü S. Gastroözofageal reflü hastalarında özofajit sıklığının ve şiddetinin değerlendirilmesi. Endoskopi Gastrointestinal. 2010;18:1–4.
MLA Çelebi, Altay vd. “Gastroözofageal Reflü hastalarında özofajit sıklığının Ve şiddetinin değerlendirilmesi”. Endoskopi Gastrointestinal, c. 18, sy. 1, 2010, ss. 1-4.
Vancouver Çelebi A, Bozkurt N, Duman AE, Dindar G, Şentürk Ö, Hülagü S. Gastroözofageal reflü hastalarında özofajit sıklığının ve şiddetinin değerlendirilmesi. Endoskopi Gastrointestinal. 2010;18(1):1-4.