Evre 2 kolon tümörlerinde klinikopatolojik faktörlerin sağkalımla ilişkisi

Yıl 2020, Cilt: 28 Sayı: 2, 47 - 51, 30.08.2020

Salih Kılıç Dinçer Aydın

https://doi.org/10.17940/endoskopi.795836

Öz

Giriş ve Amaç: Kolorektal kanserler tüm dünyada ve ülkemizde sindirim sistemi kanserlerinin başında gelmektedir. Kolorektal kanserlerin prognozunu etkileyen ve tedavide değişikliğe yol açan birçok prognostik faktör bulunmaktadır. Bu prognostik faktörler hem genel sağkalımı hem de hastalıksız sağkalımı etkilediği gibi bazıları tedavinin takibinde de kullanılabilmektedir. Çalışmamızda kolorektal kanserin prognozunu etkileyen klinikopatolojik faktörlerin genel ve hastalıksız sağ kalım üzerine olan etkilerinin gösterilmesi planlanmıştır. Gereç ve Yöntem: Ocak 2000-Aralık 2014 arasında Kartal Dr. Lütfi Kırdar Eğitim ve Araştırma Hastanesi Tıbbi Onkoloji Polikliniğine başvuran ardışık 277 evre 2 kolorektal kanserli hasta çalışmaya alınmıştır. Hastalar histopatolojik verilerine göre değerlendirilmiş ve poliklinik ve patolojik kayıtları incelenerek hastalıksız sağ kalım ve genel sağ kalım süreleri belirlenmiştir. Bulgular: Çalışmaya 159 (%57.4) erkek 118 (%42.6) kadın olmak üzere toplam 277 kişi dahil edildi. Hastaların medyan yaşı 60 (aralık 28-89) idi. 277 hastanın medyan sağkalım süresi 21 (aralık 1-184) aydı. Sonuç: Perinöral invazyon ve tanı anındaki T evresinin genel sağkalım üzerine istatistiksel etkisi olduğu izlenirken; lenfovasküler invazyon, perinörel invazyon, T evresi, tümör yerleşimi ve obstrüksiyon varlığının hastalıksız sağkalım üzerine istatistiksel etkisi olduğu görüldü.

Anahtar Kelimeler

Evre 2 kolon tümörleri, genel sağkalım, hastalıksız sağkalım

Relationship between clinicopathological factors and prognosis in stage 2 colon cancer

Öz

Background and Aims: Colorectal cancer is the leading cancer of the digestive system affecting people worldwide. There are several prognostic factors that influence the prognosis of colorectal cancers and demonstrate changes with treatment. These prognostic factors affect both the overall and disease-free survival, some of which can be applied in the treatment follow-up. Here, we investigated the effects of clinicopathological factors on the overall and disease-free survival of patients that affected the prognosis of colorectal cancer. Material and Methods: We included 277 consecutive patients with stage 2 colorectal cancer admitted to the Kartal Dr. Lütfi Kırdar Training and Research Hospital Medical Oncology Outpatient Clinic between January 2000 and December 2014. The study patients were evaluated according to their histopathological data, and their disease-free and overall survival periods were determined by examining the outpatient and pathological medical records. Results: Of the 277 study subjects, 159 (57.4%) were men and 118 (42.6%) were women of a median age 60 years (age range: 28-89 years). The median survival time of the patients was 21 (range: 1-184) months. Conclusion: We observed that the T-stage at the time of diagnosis and perineural invasion had a statistical effect on the overall survival and that lymphovascular invasion, peripheral invasion, T-stage, tumor placement, and obstruction trait had statistical effects on the disease-free survival.
Keywords: , , disease-free survival

Anahtar Kelimeler

Stage 2 colon tumors, overall survival

Kaynakça

• 1-Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015;65:5-29.
• 2- Eddy DM. Screening for colorectal cancer. Ann Intern Med 1990;113:373-84.
• 3- Levin B, Lieberman DA, McFarland B, et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology 2008;134:1570-95.
• 4- Stapley S, Peters TJ, Sharp D, Hamilton W. The mortality of colorectal cancer in relation to the initial symptom at presentation to primary care and to the duration of symptoms: a cohort study using medical records. Br J Cancer 2006; 95:1321-5.
• 5- Burton S, Norman AR, Brown G, et al. Predictive poor prognostic factors in colonic carcinoma. Surg Oncol 2006;5:71-8.
• 6- Enker WE, Havenga K, Polyak T, et al Abdominoperineal resection via total mesorectal excision and autonomic nerve preservation for low rectal cancer. World J Surg 1997;21:715-20.
• 7- Küpelioğlu AA. Kolorektal kanserde histopatoloji. Turkiye Klinikleri J Surgery 2004;9:25-7.
• 8- Chen JS, Hsieh PS, Chiang JM, et al. Clinical outcome of signet ring cell carcinoma and mucinous adenocarcinoma of the colon. Chang Gung Med J 2010;33:51-7.
• 9-Rosai J. Ackerman’s Surgical Pathology: Gastrointestinal Tract. 8th. Ed. St. Louis: The CV Mosby Company, 1996;589-800.
• 10-Wiggers T, Arends JW, Schutte B, et al. A multivariate analysis of pathologic indicators in large bowel cancer. Cancer 1988;61:386-95.
• 11- Read TE, Mutch MG, Chang BW, et al. Locoregional recurrence and survival after curative resection of adenocarcinoma of the colon. J Am Coll Surg 2002;195:33-40.
• 12- Radespiel-Tröger M, Hohenberger W, Reingruber B. Improved prediction of recurrence after curative resection of colon carcinoma using tree-based risk stratification. Cancer 2004;100:958-67.
• 13- Sökmen S. Kolorektal kanserde prognoz, kolorektal özel sayısı. Türkiye Klinikleri Journal of Surgery 2004;9:57-65.
• 14- Cohen AM, Tremittera S, Candela F, et al. Prognosis of node – positive colon cancer. Cancer 1991;67:1859-61.
• 15- Petersen VC, Baxter KJ, Love SB, Shepherd NA. Identification of objective pathological prognosis determinants and models of prognosis in Dukes‘ B colon cancer. Gut 2002;51:65-9.
• 16- Rault A, Collet D, Sa Cunha A, et al. Surgical management of obstructed colonic cancer. Ann Chirr 2005;130:331-5.
• 17- Newland RC, Dent OF, Lyttle MN, et al. Pathologic determinants of survival associated with colorectal cancer with lymph node metastases. A multivariate analysis of 579 patients. Cancer 1994;73:2076-82.