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Niklozamidin Galleria mellonella L. (Lepidoptera: Pyralidae)'nın bazı biyolojik ve fizyolojik özelliklerine etkisi

Yıl 2014, Cilt: 38 Sayı: 1, 83 - 100, 01.02.2014
https://doi.org/10.16970/ted.87976

Öz

The salisilanilides function by inhibiting mitocondrial oxidative phosphorylation in parasitic tapeworms and thus they are used as an antiparasitic drug in medicine and veterinary. While the potent antihelmintic activity of niclosamide has been well characterised in mammals, this study investigated the in vivo insecticide effect of niclosamide using larvae of the insect Galleria mellonella. Niclosamide was successful in decreasing the survival of 7th instar larvae, pupal and adult stages while only the highest concentration of this antihelmintic antibiotic (1.0 %) significantly prolonged developmental time to adult stage. Fecundity of females was obtained as 78.6 ± 6.1 number of eggs/day/female in control diet. Fecundity were increased to 114.7 ± 10.9 at 0.1% of niclosamide. However, we could not obtain any egg at the highest concentration. An increase in the male adult longevity was obtained when reared with the highest concentrations of niclosamide. Niclosamid rearing resulted in a decrease in hatchability of eggs. Niclosamide at 0.1 % of concentration increased malondialdehyde (MDA) content (4-fold), glutathion-S-transferase (GST) activity (2-fold). Relative to control (133.24 ± 23.6 nmol/mg protein), niclosamide at tested concentrations significantly increased protein carbonyl (PCO) content at least 5-fold (701.24- 808.02 nmol/mg protein). This work indicates that G. mellonella larvae may be used as a good model to ascertain importance of clincally important antihelmintic drug active ingredients in chemical management of pest insects. The results of this work also indicate that the negative effects of niclosamide on insect biology are due to its pro-oxidant properties and also to the ability of niclosamide in crippling the insect’s antioxidan defence response

Kaynakça

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The effect of niclosamide on some biological and physiological aspects of Galleria mellonella L. (Lepidoptera: Pyralidae)

Yıl 2014, Cilt: 38 Sayı: 1, 83 - 100, 01.02.2014
https://doi.org/10.16970/ted.87976

Öz

Salisilanilidler bağırsak şeridi gibi parazitlerin mitokondrisinde oksidatif fosforilasyonu inhibe ederek etkisini gösterirler ve bu antiparazitik ilaçlar tıpta ve veterinerlikte kullanılmaktadır. Niklozamidin potansiyel antihelmintik aktivitesi memelilerde iyi bir şekilde ortaya konulmuş, bu çalışmada da Galleria mellonella larvaları kullanılarak niklozamidin in vivo insektisit etkisi araştırılmıştır. Niklozamid, 7. dönem larva, pupa ve ergin evrelerinin yaşama oranını önemli derecede düşürürken, en yüksek konsantrasyonu (% 1,0) ergin gelişme süresini önemli derecede uzatmıştır. Dişilerin yumurta verimi kontrol besininde 78,6 ± 6,1 yumurta sayısı/gün/dişi olarak tespit edilmiştir. % 0,1’lik niklozamid ile beslenildiğinde ise bu değer 114,7 ± 10,9 yumurta sayısı/gün/dişi’ a yükselmiştir; bunun yanısıra en yüksek konsantrasyonda (% 1,0) hiç yumurta elde edilememiştir. Niklozamidin en yüksek konsantrasyonunda (% 1,0) erkek ergin ömür uzunluğu artmıştır. Ayrıca, niklozamid yumurta açılımını da denenen tüm konsantrasyonlarda önemli oranda düşürmüştür. % 0,1’lik niklozamid konsantrasyonunda malondialdehit (MDA) miktarı 4 kat, glutatyonS-transferaz enzimi (GST) aktivitesi ise 2 kat artmıştır. Kontrol besinine göre (133,24 ± 23,6 nmol/mg protein) niklozamidin denenen konsantrasyonları protein karbonil (PCO) miktarını en az 5 kat (701,24 - 808,02 nmol/mg protein) önemli derecede arttırmıştır. Bu çalışmada Galleria mellonella model böcek olarak kullanılarak, böceklerle mücadelede belirli klinik öneme sahip antihelmintik ilaçların aktif şekilde kullanılabilirliği belirtilmiştir. Ayrıca, bu çalışmanın sonuçları niklozamidin prooksidan etkisine bağlı olarak biyolojik ve aynı zamanda böceğin antioksidan savunma cevabı üzerine negatif etkisi olduğunu göstermiştir

Kaynakça

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  • Gaaboub, I. A. & M.R. Dawood, 1974. Effects of sublethal concentrations of DDT and malathion on the fecundity and reproduction of culex pipiens l. Zeit. Ang. Entomology, 22: 435-443.
  • George, P.J.E., J. Kannag & D.P. Ambrose, 2002. Nutritional influence of prey on the biology and biochemistry in Rhynocoris marginatus (Heteroptera: Reduviidae). Egyptian Journal of Biological Pest Control,16: 1-4.
  • Giordano G., Z. Afsharinejad, M. Guizzetti, A. Vitalone, T.J. Kavanagh & L.G. Costa, 2007. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology, 219:181-189.
  • Grover, J. K., V. Vats, G. Uppal & S. Yadav, 2001. Antihelmintics: a review, Trop. Gastroenterology, 22: 180-9.
  • Gülbahar, Ö.,2007. Protein oksidasyonun mekanizması, önemi ve yaşlılıkla ilgisi. Turkısh Journal of Geriatrics, 10: 43-48
  • Gündüz, N.E.A. & A. Gülel, 2005. Ergin yaşı ve konukçu türünün parazitoit Bracon hebetor (Say) (Hymenoptera: Braconidae)’ un gelişme süresine etkisi. Ondokuz Mayıs Üniversitesi Ziraat Fakültesi Dergisi, 20: 31-36.
  • Habig, W. H., M.J. Pabst & W.B. Jakoby, 1974. Glutathione S-transferases: The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry, 249: 7130-7139.
  • Halley B.A., T.A. Jacob & A.Y.H. Lu, 1989. The environmental impact of the use of ivermectin. Environmental effects and fate. Chemosphere, 18: 1543-1563.
  • Hermes-Lima, M. & T. Zenteno-Savín, 2002. Animal response to drastic changes in oxygen availability and physiological oxidative stress. Comparative Biochemistry and Physiology Part C: Toxicology. 133: 537-56.
  • Hill, T.A. & R.E. Foster, 2000. Effect of insecticides on the diamondback moth (Lepidoptera: Plutellidae) and its parasitoid Diadegma insulare (Hymenoptera: Ichneumonidae). Journal of Economic Entomology, 93: 763-768.
  • Hirose, E., A.R. Panizzi & A.J. Cattelan, 2006. Potential use of antibiotic to improve performance of laboratory-reared Nezara viridula (L.) (Heteroptera: Pentatomidae). Neotropical Entomology, 35: 279-281.
  • Imperi, F., F. Massai, C. Ramachandran Pillai, F. Longo, E. Zennaro, G. Rampioni, P. Visca, & L. Leoni, 2013. New life for an old drug: the Anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa Quorum sensing. Antimicrobial Agents and Chemotherapy. 57: 996-1005.
  • Inglis, G.D. & A.C. Cohen, 2004. Influence of antimicrobial agents on the spoilage of a meat-based entomophage diet. Journal of Economic Entomology, 97: 235-250.
  • Ito, K. & T. Nakata, 1998. Diapause and survival in winter in two species of predatory bugs, Orius sauteri and O. minutus. Entomologia Experimentalis et Applicata, 89: 271-276.
  • Dean, R.T., S. Fu, R. Stocker & M.J. Davies, 1997. Biochemistry and pathology of radical-mediated protein oxidation. Journal of Biochemistry, 324: 1-18.
  • Dettbarn, W.F., D. Milatovic & R.C. Gupta, 2006. “Oxidative Stress in Anticholinesterase-Induced Excitotoxicity, 511– 532”. In: Toxicology of Organophosphate and Carbamate Compounds (Ed.: R.C. Gupta). Elsevier, Amsterdam..
  • Ding, Y., N. Hawkes, J. Meredith, P. Eggleston, J. Hemingway & H. Ranson, 2005. Characterization of the promoters of Epsilon glutathione transferases in the mosquito Anopheles gambiae and their response to oxidative stress. Biochemical Journal, 387: 879-888.
  • Dulhunty, A., P. Gage, S.Curtis, G. Chelvanayagam & P. Board, 2001. The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator, Journal of Biological Chemistry, 276: 3319-3323.
  • Ergin, E., A. Er, F. Uçkan & D.B. Rivers, 2007. Effect of cypermethrin exposed hosts on eggadult development time, number of offspring, sex ratio, longevity, and size of Apanteles galleriae Wilkinson (Hymenoptera: Braconidae). Belgian Journal of Zoology, 137: 27-31.
  • Evans, P., L. Lyras & B. Halliwel, 1999. Measurement of protein carbonyls in human brain tissue. Methods in Enzymology, 300: 145-156.
  • Felton, G.W. & C.B. Summers, 1995. Antioxidant systems in insects. Archives of Insect Biochemistry and Physiology, 29: 187-197.
  • Fitzpatrick, G.E. & R.V. Dowell, 1981. Survival and emergence of citrus black fly (Aleurocanthus woglumi) parasitoids after exposure two insectidices. Environmental Entomology, 10: 728-731.
  • Gaaboub, I. A. & M.R. Dawood, 1974. Effects of sublethal concentrations of DDT and malathion on the fecundity and reproduction of culex pipiens l. Zeit. Ang. Entomology, 22: 435-443.
  • George, P.J.E., J. Kannag & D.P. Ambrose, 2002. Nutritional influence of prey on the biology and biochemistry in Rhynocoris marginatus (Heteroptera: Reduviidae). Egyptian Journal of Biological Pest Control,16: 1-4.
  • Giordano G., Z. Afsharinejad, M. Guizzetti, A. Vitalone, T.J. Kavanagh & L.G. Costa, 2007. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology, 219:181-189.
  • Grover, J. K., V. Vats, G. Uppal & S. Yadav, 2001. Antihelmintics: a review, Trop. Gastroenterology, 22: 180-9.
  • Gülbahar, Ö.,2007. Protein oksidasyonun mekanizması, önemi ve yaşlılıkla ilgisi. Turkısh Journal of Geriatrics, 10: 43-48
  • Gündüz, N.E.A. & A. Gülel, 2005. Ergin yaşı ve konukçu türünün parazitoit Bracon hebetor (Say) (Hymenoptera: Braconidae)’ un gelişme süresine etkisi. Ondokuz Mayıs Üniversitesi Ziraat Fakültesi Dergisi, 20: 31-36.
  • Habig, W. H., M.J. Pabst & W.B. Jakoby, 1974. Glutathione S-transferases: The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry, 249: 7130-7139.
  • Halley B.A., T.A. Jacob & A.Y.H. Lu, 1989. The environmental impact of the use of ivermectin. Environmental effects and fate. Chemosphere, 18: 1543-1563.
  • Hermes-Lima, M. & T. Zenteno-Savín, 2002. Animal response to drastic changes in oxygen availability and physiological oxidative stress. Comparative Biochemistry and Physiology Part C: Toxicology. 133: 537-56.
  • Hill, T.A. & R.E. Foster, 2000. Effect of insecticides on the diamondback moth (Lepidoptera: Plutellidae) and its parasitoid Diadegma insulare (Hymenoptera: Ichneumonidae). Journal of Economic Entomology, 93: 763-768.
  • Hirose, E., A.R. Panizzi & A.J. Cattelan, 2006. Potential use of antibiotic to improve performance of laboratory-reared Nezara viridula (L.) (Heteroptera: Pentatomidae). Neotropical Entomology, 35: 279-281.
  • Imperi, F., F. Massai, C. Ramachandran Pillai, F. Longo, E. Zennaro, G. Rampioni, P. Visca, & L. Leoni, 2013. New life for an old drug: the Anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa Quorum sensing. Antimicrobial Agents and Chemotherapy. 57: 996-1005.
  • Inglis, G.D. & A.C. Cohen, 2004. Influence of antimicrobial agents on the spoilage of a meat-based entomophage diet. Journal of Economic Entomology, 97: 235-250.
  • Ito, K. & T. Nakata, 1998. Diapause and survival in winter in two species of predatory bugs, Orius sauteri and O. minutus. Entomologia Experimentalis et Applicata, 89: 271-276.
  • Mullens, B.A. & J.L. Rodriguez, 1992. Effects of disodium octaborate tetrahydrate on survival, behavior, and egg viability of adult muscoid flies (Diptera: Muscidae). Journal of Economic Entomology, 85: 137-143.
  • Otitoju, O. & I.N.E. Onwurah, 2007. Glutathione S-transferase (GST) activity as a biomarker in ecological risk assessment of pesticide contaminated environment. African Journal of Biotechnology, 6: 1455-1459.
  • Özalp, P. & İ. Emre, 1998. Karbohidratların Pimpla turionellae L. ergin dişilerinde total glikojen ve protein miktarına etkileri. Turkish Journal of Biology, 22: 15-19.
  • Özparlak, H., 2003. Böceklerde kutikulanın yapısı, deri değiştirme ve diflubenzuron’un (dfb) etkileri. S.Ü. Fen-Edb. Fakültesi Fen Dergisi, 21: 7-19.
  • Pearson, B. & A.F. Raybould, 1998. The effects of antibiotics on the development of larvae and the possible role of bacterial load in caste determination and diapause in Myrmica rubra (Hymenoptera: Formicidae). Sociobiology, 31: 77-90.
  • Pullin, A., 1992. Diapause metabolism and changes in carbohydrates related to cryoprotection in Pieris brassicae. Journal of Insect Physiology, 38: 319-327.
  • Rajurkar, R.B., Z.H. Khan & G.T. Gujar, 2003. Studies on levels of glutathione-S-transferase, its isolation and purification from Helicoverpa armigera. Current Science, 85: 1355-1360.
  • Sak, O., E.E. Gülgönül & F. Uçkan, 2009. Effects of cypermethrin exposed to host on the developmental biology of Pimpla turionellae (Hymenoptera: Ichneumonidae). Annals of the Entomological Society of America,102: 288- 294.
  • Seyoum, E., R.P. Bateman & A.K. Charnley, 2002. The effect of Metarhizium anisopliae var aerdium on haemolymph energy reserves and flight capability in the desert locust, Schistocerca gregaria. Journal of Applied Entomology, 126: 119-124.
  • Sheehan, D., G. Meade, V.M. Foley & C.A. Dowd, 2001. Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochemical Journal, 360: 1-16.
  • Simon, L.M., K. Laslo, M. Kotorman, A. Vertesi, K. Bagi, & J. Nemcsok, 1999. Effects of synthetic pyrethroids and methidation on activities of some digestive enzymes in carp (Cyprinus carpio L.). Journal of Environmental Science and Health, Part B., 34: 819-828.
  • Singh, S.P., J.A. Coronella, H. Benes, B.J. Cochrane & P. Zimniak, 2001. Catalytic function of Drosophila melanogaster glutathione S-transferase DmGSTS1-1 (GST2) in conjugation of lipid peroxidation end products. European Journal of Biochemistry, 268: 2912-2923.
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  • Socha, R., J. Sula & R. Zemek, 1998. Feeding behaviour, digestive physiology and lipid content in macropterous females of Pyrrhocoris apterus L. (Heteroptera: Pyrrhocoridae). Physiological Entomology, 23: 91-96.
  • Spıteller, G., 2001. Peroxidation of linoleic acid and its relation to aging and age dependent diseases. Mechanisms of Ageing and Development, 122: 617-657.
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  • Şeker, D.A. & A. Yanıkoğlu, 1999. Pimpla turionellae L. (Hymenoptera: Ichneumonidae)’ nın açlık, beslenme, parazitleme ve yaşlılık durumlarında glikojen seviyesindeki değişmeler. Turkish Journal of Zoology, 23: 289- 296.
  • Takada, Y., S. Kawamura & T. Tanaka, 2001. Effects of various insecticides on the development of the egg parasitoid Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae). Journal of Economic Entomology, 94: 1340-1343.
  • Valavanidis, A., T. Vlahogianni, M. Dassenakis & M. Scoullos, 2006. Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants. Ecotoxicology and Environmental Safety, 64: 178-189.
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  • Vontas, J.G., G.J. Small & J. Hemingway, 2001. Glutathione-s-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens. Biochemical Journal, 357: 65-72.
  • Wang, A.H., J.C. Wu, Y.S. Yu, J.L. Liu, J.F. Yue & M.Y. Wang, 2005. Selective insecticde-induced stimulation on fecundity and biochemical changes in Tryporyza incertulas (Lepidoptera: Pyralidae). Journal of Economic Entomology, 98: 1144-1149.
  • Warburg, M.S. & B. Yuval, 1996. Effects of diet and activity on lipid levels of mediterranean fruit flies. Physiological Entomology, 21: 151-158.
  • Willrich, M.M. & D.J. Boethel, 2001. Effects of diflubenzuron on Pseudoplusia includens (Lepidoptera: Neoctuidae) and its parasitoid Copidosoma floridanum (Hymenoptera: Encyrtidae). Environmental Entomology, 30: 794- 797.
  • Xu, J., A.M. Shelton & X. Cheng, 2001. Comparison of Diadegma insulare (Hymenoptera: Ichneumonidae) and Microplitis plutellae (Hymenoptera: Braconidae) as biological control agents of Plutella xylostella (Lepidoptera: Plutellidae): field parasitism insecticide susceptibility, and host-searching. Journal of Economic Entomology, 94: 14-20.
  • Yang, L.K., H.N. Nigg, S.E. Simpson, L.E. Ramos, N.W. Cuyler, J.I. Barnes & C.G. Gren, 2000. Sodium tetraborate effects on mortality and reproduction of Anastrepha suspensa (Diptera: Tephritidae). Journal of Economic Entomology, 93: 1485-1492.
  • Yanıkoğlu, A. 1985. Schistocerca gregaria Forskal (Orthoptera: Acrididae) nimflerinin doğal ve sentetik besinde gelişimi sırasında glikojen miktarı tayini. Doğa Bilim Dergisi, 9: 582-592.
  • Yu, Q., S. Fang, W. Zuo, F. Dai, Z. Zhang & C. Lu 2011. Effects of organophosphate phoxim exposure on certain oxidative stres biomarkers in the silkworm. Journal of Economic Entomology, 104: 101-106.
  • Yu, S.J., 1993. Induction of detoxification enzymes in phytophagous insects: Roles of insecticide synergists, larval age, and species, Archives of Insect Biochemistry and Physiology, 24: 21-32.
  • Yu, S.J., 1996. Insect glutathione-S-transferase, Zoological Studies, 35: 9-19.
  • Yu, S.J., 2004. Induction of detoxification enzymes by triazine herbicides in the fall armyworm, Spodoptera frugiperda, Pesticide Biochemistry and Physiology, 80: 113-122.
  • Zettler, J.L. & G. L. LeCato, 1974. Sublethal doses of malathion and dichlorvos: Effects on fecundity of the black carpet betle. Journal of Economic Entomology, 67: 19- 21.
Toplam 98 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Ender Büyükgüzel Bu kişi benim

Selver Kayaoğlu Bu kişi benim

Yayımlanma Tarihi 1 Şubat 2014
Gönderilme Tarihi 26 Ocak 2015
Yayımlandığı Sayı Yıl 2014 Cilt: 38 Sayı: 1

Kaynak Göster

APA Büyükgüzel, E. ., & Kayaoğlu, S. . (2014). The effect of niclosamide on some biological and physiological aspects of Galleria mellonella L. (Lepidoptera: Pyralidae). Turkish Journal of Entomology, 38(1), 83-100. https://doi.org/10.16970/ted.87976
AMA Büyükgüzel E, Kayaoğlu S. The effect of niclosamide on some biological and physiological aspects of Galleria mellonella L. (Lepidoptera: Pyralidae). TED. Şubat 2014;38(1):83-100. doi:10.16970/ted.87976
Chicago Büyükgüzel, Ender, ve Selver Kayaoğlu. “The Effect of Niclosamide on Some Biological and Physiological Aspects of Galleria Mellonella L. (Lepidoptera: Pyralidae)”. Turkish Journal of Entomology 38, sy. 1 (Şubat 2014): 83-100. https://doi.org/10.16970/ted.87976.
EndNote Büyükgüzel E, Kayaoğlu S (01 Şubat 2014) The effect of niclosamide on some biological and physiological aspects of Galleria mellonella L. (Lepidoptera: Pyralidae). Turkish Journal of Entomology 38 1 83–100.
IEEE E. . Büyükgüzel ve S. . Kayaoğlu, “The effect of niclosamide on some biological and physiological aspects of Galleria mellonella L. (Lepidoptera: Pyralidae)”, TED, c. 38, sy. 1, ss. 83–100, 2014, doi: 10.16970/ted.87976.
ISNAD Büyükgüzel, Ender - Kayaoğlu, Selver. “The Effect of Niclosamide on Some Biological and Physiological Aspects of Galleria Mellonella L. (Lepidoptera: Pyralidae)”. Turkish Journal of Entomology 38/1 (Şubat 2014), 83-100. https://doi.org/10.16970/ted.87976.
JAMA Büyükgüzel E, Kayaoğlu S. The effect of niclosamide on some biological and physiological aspects of Galleria mellonella L. (Lepidoptera: Pyralidae). TED. 2014;38:83–100.
MLA Büyükgüzel, Ender ve Selver Kayaoğlu. “The Effect of Niclosamide on Some Biological and Physiological Aspects of Galleria Mellonella L. (Lepidoptera: Pyralidae)”. Turkish Journal of Entomology, c. 38, sy. 1, 2014, ss. 83-100, doi:10.16970/ted.87976.
Vancouver Büyükgüzel E, Kayaoğlu S. The effect of niclosamide on some biological and physiological aspects of Galleria mellonella L. (Lepidoptera: Pyralidae). TED. 2014;38(1):83-100.