Neutrophil to lymphocyte and platelet to lymphocyte ratios as an indicator of inflammation in patients with recurrent aphthous stomatitis

Yıl 2018, Cilt: 8 Sayı: 1, 41 - 44, 05.04.2018

Mustafa Kule Asude Kara Polat Aslı Akın Belli Zeynep Gökçen Kule

Öz

Objective: Recently, the ratios of
neutrophil to lymphocyte (NL) and platelet to lymphocyte (PL) have been
used as an indicator of inflammation. We aimed to investigate the
relation of recurrent aphthous stomatitis (RAS) to inflammation by
analyzing the ratios of NL and PL.




Methods: We
conducted a case-control study on 143 patients with RAS and 134 healthy
control cases between February 2015 and March 2016. Age, sex, neutrophil
count, platelet count, lymphocyte count, and the ratios of NL and PL of
the participants were recorded.




Results: One
hundred and forty-three RAS patients and 134 control cases were
included in the study. The ratios of NL and PL of RAS group were
significantly higher than in the control group (p=0.004 and p=0.010,
respectively). The NL ratio was the only independent predictor of RAS in
multivariate logistic regression analysis (p=0.014). The cut-off value
of NL ratio for predicting RAS was 3.49 with 13.3% sensitivity and 99.9%
specificity (p=0.010).




Conclusion: We
have found that the ratios of NL and PL were higher in RAS group than
the control group. The results of our study support that inflammation
has an important role in the pathogenesis of RAS.

Anahtar Kelimeler

Lymphocyte, neutrophil, platelet, recurrent aphthous stomatitis

Kaynakça

• 1. Eisen D, Lynch DP. Selecting topical and systemic agents for recurrent aphthous stomatitis. Cutis 2001;68:201–6. 2. Brocklehurst P, Tickle M, Glenny AM, et al. Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). Cochrane Database Syst Rev 2012;(9):CD005411. 3. Ça¤layan F, Y›lmaz AB. Recurrent aphthous stomatitis. Journal of Faculty of Dental Faculty of Atatürk University 2008;3:99–104. 4. Avci E, Akarslan ZZ, Erten H, Coskun-Cevher S. Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers. Braz J Med Biol Res 2014;47:355–60. 5. Sun A, Chang YF, Chia JS, Chiang CP. Serum interleukin-8 level is a more sensitive marker than serum interleukin-6 level in moni toring the disease activity of recurrent aphthous ulcerations. J Oral Pathol Med 2004;33:133–9. 6. Messadi DV, Younai F. Aphthous ulcers. Dermatol Ther 2010;23:281–90. 7. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012;5:2. 8. Peng W, Li C, Wen TF, et al. Neutrophil to lymphocyte ratio changes predict small hepatocellular carcinoma survival. J Surg Res 2014;192:402–8. 9. Templeton AJ, Knox JJ, Lin X, et al. Change in neutrophil-to-lymphocyte ratio in response to targeted therapy for metastatic renal cell carcinoma as a prognosticator and biomarker of efficacy. Eur Urol 2016;70:358–64. 10. Chavan M, Jain H, Diwan N, Khedkar S, Shete A, Durkar S. Recurrent aphthous stomatitis: a review. J Oral Pathol Med 2012;41:577–83. 11. Topkarc› Z. Current treatment options in challenging oral diseases: recurrent oral aphthosis. Turkderm 2012;46(Suppl2):123–9. 12. Venkatraghavan L, Tan TP, Mehta J, Arekapudi A, Govindarajulu A, Siu E. Neutrophil lymphocyte ratio as a predictor of systemic inflammation – a cross-sectional study in a pre-admission setting. F1000Res 2015;4:123. 13. Lou M, Luo P, Tang R, et al. Relationship between neutrophil lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord 2015;15:9. 14. Soylu Özler G, Ako¤lu E. The relationship between neutrophil to lymphcyte ratio and recurrent aphthous stomatitis. J Clin Anal Med 2016;7:152–4. 15. Seçkin HY, Bütün I, Bafl Y, Takc› Z, Kalkan G. Effects of colchicine treatment on mean platelet volume and the inflamma- tory markers in recurrent aphthous stomatitis. J Dermatolog Treat 2016;27:389–91. 16. Terzi S, Dursun E, Özgür A, et al. Status of neutrophils, lymphocytes and platelets in patients with recurrent aphthous stomatitis: a retrospective study. Iran J Otorhinolaryngol 2016;28:421–4. 17. Sen BB, Rifaioglu EN, Ekiz O, Inan MU, Sen T, Sen N. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol 2014;3:223–7. 18. Torun S, Tunc BD, Suvak B, et al. Assessment of neutrophil-lymphocyte ratio in ulcerative colitis: a promising marker in predicting disease severity. Clin Res Hepatol Gastroenterol 2012;36:491–7. 19. Ozbay I, Kahraman C, Balikci HH, et al. Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: prospective, controlled clinical study. J Laryngol Otol 2015;129:544–7. 20. Ozbay I, Kahraman C, Balikci HH, et al. Neutrophil-to-lymphocyte ratio in patients with peripheral vertigo: a prospective con- trolled clinical study. Am J Otolaryngol 2014;35:699–702. 21. Ulu S, Ulu MS, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2013;34:1400–4. 22. Atan D, ‹kincio¤ullar› A, Köseo¤lu S, et al. New predictive parameters of Bell’s palsy: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Balkan Med J 2015;32:167–70.