Köpeklerde İmmun Aracılı Göz Hastalıkları

Öz

Bağışıklık sistemi vücudun en karmaşık ve kapsamlı parçalarından birisidir. Canlının yaşamı boyunca karşılaşabi- leceği potansiyel patojenlerin etkili bir şekilde eliminasyonunu sağlamak için gelişmiştir. Vücudun bu savunma sistemi, fizyolojik düzeni bozan patojenler yerine konağa yönlendirildiğinde otoimmun hastalıklar ortaya çıkar. Göz, vücuttan bağımsız olarak kendi içinde lokal bağışıklığı sağlayıp korumak ve kontrol altına almak için organa özgü immunolojik bir yapı ile şekillenmiştir. Göz içinde herhangi bir patojene ya da yerleşik bulunan hücre gruplarına verilen anormal immun yanıt sonucu oluşacak patolojik değişimler görmeyi tehdit edebilir. Köpeklerde özellikle gözün anterior segmen- tinde bulunan yapılara karşı istenmeyen immunolojik reaksiyonlar ortaya çıkabilmektedir. İmmun aracılı hastalıkların klinik muayene ve laboratuvar testleri ile erken tanısı, hastalığın tedavisi ve prognozu açısından önem arz eder. Bu derlemenin amacı, köpeklerde en sık karşılaşılan immun sistem kaynaklı göz hastalıklarının etiyoloji, klinik görünüm, histopatolojik bulgular ve tedavisi hakkında bilgi vermektir.

Anahtar Kelimeler

• Bağışıklık
• bulbus okuli
• konjunktiva
• otoimmun
• Autoimmune
• bulbus oculi
• conjunctiva
• immunity

Immune-Mediated Eye Diseases in Dogs

Öz

The immune system is one of the most complex and comprehensive parts of the body. It has been developed to effectively eliminate potential pathogens that may encounter throughout the animals’ life. Autoimmune diseases occur when this defence system of the body is directed to the host instead of pathogens that disrupt the physiological order. The eye has consisted with an organ-specific immunological structure in order to maintain and control local immunity, independent of the body. Pathological changes that will occur as a result of an abnormal immune response to any pathogen or resident cell groups in the eye may threaten the vision. Undesirable immunological reactions can occur in dogs, especially against structures in the anterior segment of the eye. Early diagnosis of immune-mediated diseases with clinical examination and laboratory tests is important for the treatment and prognosis of the disease. The purpose of this review is to provide information about the etiology, clinical appearance, histopathological findings and treatment of the most common immune system-related eye diseases in dogs.

Anahtar Kelimeler

• Autoimmune
• bulbus oculi
• conjunctiva
• immunity

Kaynakça

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