Aydın İlindeki Kedilerde FeLV ve FIV Enfeksiyonlarının Belirlenmesi

Yıl 2023, , 186 - 191, 04.12.2023

Mustafa Esen , Öznur Aslan

https://doi.org/10.32707/ercivet.1388920

Öz

Bu çalışmanın amacı, Aydın ilinde yaşan kedilerde kedi lösemi virusu (FeLV) ve kedi immun yetmezlik virusu (FIV)
varlığının belirlenmesidir. Çalışmanın materyalini; tedavi, kontrol, kastrasyon, kısırlaştırma, anti-paraziter uygulama ve
aşı gibi çeşitli sebeplerle Aydın’daki özel bir kliniğe başvuran yaşları 6 aylık ve üzeri olan farklı ırk [Sfenks (2), British
Shorthair (12), Scottish Fold (5), Tekir (68), İran kedisi (3), Himalayan (3), Siyam (3), Chincila (1), Bombay (1), Russian
Blue (1), Van kedisi (1)] ve cinsiyetteki (E= 51, D= 49) rastgele seçilen 100 kediden toplanan kan örnekleri oluşturdu.
Çalışmaya dahil edilen kedilerin klinik muayeneleri yapılarak, alınan kan örneklerinde hemogram ölçümleri ile FIV anti-
koru ve FeLV antijeni yönünden hızlı tanı testi [Bionote® , Anigen Rapid (FIV Ab/FeLV Ag), Güney Kore] yapıldı. Örnek
alınan kedilerin üçünde (%3) FIV antikorunun pozitif, FeLV Ag (antijen) yönünden ise hepsinin negatif olduğu belirlendi.
FIV pozitif bulunan üç kediden üçünün de (%100) dişi, ikisinin Scottish Fold (4 ve 1.5 yaş) ve birinin Tekir (3 yaş) oldu-
ğu kaydedildi. Scottish Fold kedilerde herhangi bir klinik semptom gözlenmezken, birinin dışarı çıktığı ve FeLV’ye karşı
aşılanmış olduğu belirlendi. FIV pozitif belirlenen tekir kedinin klinik muayenesinde aralıklı kusmalarının olduğu ve dışa-
rıya çıktığı kaydedildi. FIV pozitif kedilerin hematolojik değerleri incelendiğinde bir kedinin kan değerlerinin hafif dehid-
rasyon dışında referans değerlerde olduğu gözlenirken, birinde lökopeni ile hafif dehidrasyon ve birinde ise lökositozis,
lenfositozis ve trompositozis belirlendi. Sonuç olarak, Aydın ilindeki kedilerde %3 oranında FIV pozitiflik belirlenirken
FeLV antijen görülme oranı %0 olarak belirlendi. FIV pozitif kedilerin klinik ve hematoloji bulgularının değişkenlik gös-
terdiği kaydedildi.

Anahtar Kelimeler

FeLV, FIV, kedi

Detection of FeLV and FIV Infections in Cats on Aydın Region

Öz

The purpose of this work is to determine of FeLV and FIV infections in cats, living in the province of Aydın.
The blood samples taken from cats, six months and older aged and different breeds [Sphynx (2) British Shorthair (12)
Scottish Fold (5) Tabby (68) Persian (3) Himalayan Cat (3) Siamese (3) Chinchilla (1) Bombay Cat (1) Russian Blue (1)
Van Cat (1)] and sexes (E= 51, D= 49), brought for the purpose treatment, control, castration, overiohsyterectomi, anti-
paraziter treatment and vaccination to a special clinic in Aydın are used as the materials of this study. The hemogram
examinations and rapid diagnostic test for FIV antibodies and FeLV antigens [Bionote®, Anigen Rapid (FIV Ab/FeLV
Ag), South Korea] were performed in blood samples taken after clinical examinations of cats. It was determined that
three (3%) of the cats tested positive for FIV antibodies, and all results to FeLV AG (antigen) were found to be negati-
ve. The three cats with FIV positive were female, two of them recorded as Scottish Folds (4 and 1.5 aged respectively)
and the other as Tekir (3 years old). While no clinical symptoms were observed in as Scottish Fold cats, it was determi-
ned that one of them went outside and vaccinated aganist FeLV. In the clinical examination of the FIV positive Tekir cat
were noted to intermittent vomiting and recored to went outside. When the hematological values of FIV-positive cats
were examined, one of the cats showed signs of minor dehydration but was within the reference range in all other as-
pects, In another cat, minor dehydration and leukopenia were observed, and in yet another leukocytosis, lymphocyte
and thrombocytosis were observed. In conclusion, while FIV positivity was determined at a rate od 3% in cats in Aydın
province, the FeLV antigen rate was found to be 0%. The clinical and hematological findings of FIV positive cats were
noted to variable.

Anahtar Kelimeler

Cat, FeLV, FIV

Kaynakça

• Addie D. Feline coronavirus infections. Green C. ed. In: Infectious Diseases of the Dog and Cat. Elsevier: Missouri, 2012; pp. 92-108.
• Bracklein T, Theise S, Metzler A, Spiess BM, Richter M. Activity of feline interferon-omega after ocular or oral administration in cats as indicated by Mx protein expression in conjunctival and white blood cells. Am J Vet Res 2006; 67(6):1025-32.
• Capozza P, Lorusso E, Colella V, Thibault JC, Tan DY, Tronel JP, Halos L, Beugnet F, Elia G, Nguyen VL, Occhiogrosso L, Martella V, Otranto D, Decaro N. Feline leukemia virus in owned cats in Southeast Asia and Taiwan. Vet Microbiol 2021; 254:109008
• Cotter SM. Management of healthy feline leukemia virus-positive cats. J Am Vet Med Assoc 1991; 199:1470-3.
• Deniz A. Evaluation of clinical findings, some hematological and biochemical findings, and age and sex status in feline immunodeficiency virus (FIV) seropositive cats with clinical symptoms and without clinical symptoms. Turk J Vet Anim Sci 2001; 25(4): 409-19.
• Englert T, Lutz H, Sauter-Louis C, Hartmann K. Survey of the feline leukemia virus infection status of cats in Southern Germany. J Feline Med Surg 2012; 14: 392-8.
• Erol N, Pasa S. An ınvestigation of the feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) infections in cats in Western Turkey. Acta Sci Vet 2013; 41(1): 1-6.
• Eto N, Yazaki-Takayama N, Takayama Y, Yoshino-Nakamura T, Kobayashi Y. Immuno-chromatographic assay for diagnosis of feline leukemia virus infection. Cytotechnology 2003; 43(1-3): 65.
• Gil S, Leal RO, Duarte A, McGahie D, Sepúlveda N, Siborro I, Tavares LM. Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter. Res Vet Sci 2013; 94(3): 753-63.
• Gleich S, Hartmann K. Hematology and serum biochemistry of feline immunodeficiency virus-infected and feline leukemia virus-infected cats. J Vet Intern Med 2009; 23: 552-8.
• Gleich SE, Krieger S, Hartmann K. Prevalence of feline immunodeficiency virus and feline leukemia virus among client-owned cats and risk factors for infection in Germany. J Feline Med Surg 2009; 11(12): 985-92.
• Hart S, Nolte I. Hemostatic disorders in feline immunodeficiency virus seropositive cats. J Vet Intern Med 1994; 8: 355-62.
• Hartmann K, Hofmann-Lehmann R. What's new in feline leukemia virus ınfection. Vet Clin North Am Small Anim Pract 2020; 50(5): 1013-36.
• Hellard E, Fouchet D, Santin-Janin H, Tarin B, Ba-dol V, Coupier C, Leblanc G, Poulet H, Pontier D. When cats’ ways of life interact with their viruses: A study in 15 natural populations of owned and unowned cats (Felis silvestris catus). Prev Vet Med 2011; 101: 250-64.
• Hennet PR, Camy GAL, McGahie DM, Albouy MV. Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: A randomised, multi-center, controlled, double-blind study in 39 cats. J Feline Med Surg 2011; 13(8): 577-87.
• Hofmann-Lehmann R, Gonczi E, Riond B, Meli M, Willi B, Howard J, Schaarschmidt-Kiener D, Reg-li W, Gilli U, Boretti F. Feline leukemia virus in-fection: importance and current situation in Switzerland. Schweiz Arch Tierheilkd 2018; 160: 95-105.
• Hosie MJ, Addie D, Belák S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hart-mann K, Lloret A, Lutz H, Marsilio F, Pennisi MG, Radford AD, Thiry E, Truyen U, Horzinek MC. Feline immunodeficiency. ABCD guidelines on prevention and management. J Feline Med Surg 2009; 11(7): 575-84.
• Hosie MJ, Robertson C, Jarrett O. Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus in cats in the United Kingdom. Vet Rec 1989; 125: 293-7.
• Jenkins KS, Dittmer KE, Marshall JC, Tasker S. Prevalence and risk factor analysis of feline haemoplasma infection in New Zealand domestic cats using a real-time PCR assay. J Feline Med Surg 2013; 15(12): 1063-9.
• Lee IT, Levy JK, Gorman SP, Crawford PC, Slater MR. Prevalence of feline leukemia virus infection and serum antibodies against feline immunodeficiency virus in unowned free-roaming cats. J Am Vet Med Assoc 2002; 220(5): 620-2.
• Levy JK, Scott HM, Lachtara JL, Crawford PC. Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in North America and risk factors for seropositivity. J Am Vet Med Assoc 2006; 228: 371-6.
• Miyazawa T, Tomonaga K, Kawaguchi Y, Mikami T. The genome of feline immunodeficiency virus. Arch Virol 1994; 134(3-4): 221-34.
• Mochizuki M, Nakatani H, Yoshida M. Inibitory effects of recombinant feline interferon on the replication of feline enteropathogenic viruses in vitro. Vet Microbiol 1994; 39: 145-52.
• Nakamura Y, Nakamura Y, Ura A, Hirata M, Saku-ma M, Sakata Y, Nishigaki K, Tsujimoto H, Seto-guchi A, Endo Y. An updated nation-wide epidemiological survey of feline immunodeficiency virus (FIV) infection in Japan. J Vet Med Sci 2010; 72(8): 1051-6.
• Norris JM, Bell ET, Hales L, Toribio JAL, White JD, Wigney DI, Malik R. Prevalence of feline immunodeficiency virus infection in domesticated and feral cats in eastern Australia. J Feline Med Surg 2007; 9(4): 300-8.
• Oğuzoğlu TÇ, Muz D, Timurkan MÖ, Maral N, Gür-can İS. Prevalences of feline coronavirus (FCoV), feline leukaemia virus (FeLV), feline ımmunodeficiency virus (FIV) and feline parvovirus (FPV) among domestic cats in Ankara, Turkey. Rev Med Vet 2013; 164(11): 511-6.
• Ohe K, Takahashi T, Hara D, Hara M. Sensitivity of FCV to recombinant feline interferon (rFeIFN). Vet Res Commun 2008; 32: 167-74.
• Overbaugh J, Donahue PR, Quackenbush SL, Hoo-ver EA, Mullins JI. Molecular cloning of a feline leukemia virus that induces fatal immunodeficiency disease in cats. Science 1988; 239: 906-10.
• Ravi M, Wobeser GA, Taylor SM, Jackson ML. Naturally acquired feline immunodeficiency virus (FIV) infection in cats from western Canada: Prevalence, disease associations, and survival analysis. Can Vet J 2010; 51(3): 271-6.
• Shelton GH, Linenberger ML, Abkowitz JL. Hematologic abnormalities in cats seropositive for feline immunodeficiency virus. J Am Vet Med Assoc 1991; 10: 1353-7.
• Spada E, Proverbio D, della Pepa A, Perego R, Baggiani L, DeGiorgi GB, Domenichini G, Ferro E, Cremonesi F. Seroprevalence of feline immunodeficiency virus, feline leukaemia virus and Toxoplasma gondii in stray cat colonies in nort-hern Italy and correlation with clinical and laboratory data. J Feline Med Surg 2012; 14: 369-77.
• Stavisky J, Dean RS, Molloy MH. Prevalence of and risk factors for FIV and FeLV infection in two shelters in the United Kingdom (2011-2012). Vet Rec 2017; 181(17): 451.
• Studer N, Lutz H, Saegerman C, Gönczi E, Meli ML, Boo G, Hartmann K, Hosie MJ. Pan-European study on the prevalence of the feline leukaemia virus ınfection - Reported by the European Advisory Board on Cat Diseases (ABCD Europe). Viruses 2019; 11(11): 993.
• Tilley LP, Smith FWK. Blackwell’s Five-Minute Veterinary Consult Canine and Feline. Sixth Edition. Iowa: Wiley-Blackwell, 2015; p. 500.
• Truyen U, Blewaska S, Schultheiss U. Antiviral potency of interferon-omega (IFN-ω) against selected canine and feline viruses. Praktische Tierarzt 2002; 83(10): 862-5.
• Westman M, Norris J, Malik R, Hofmann-Lehmann R, Harvey A, McLuckie A, Perkins M, Schofield D, Marcus A, McDonald M, Ward M, Hall E, Sheehy P, Hosie M. The diagnosis of feline leukaemia virus (FeLV) infection in owned and group-housed rescue cats in Australia. Viruses 2019a; 11(6): 503.
• Westman ME, Malik R, Norris JM. Diagnosing feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infection: an update for clinicians. Aust Vet J 2019b; 97(3): 47-55.
• Yılmaz H, Ilgaz A, Harbour DA. Prevalence of FIV and FeLV infections in cats in Istanbul. J Feline Med Surg 2000; 2(1): 69-70.
• Yuksek N, Kaya A, Altug N, Ozkan C, Agaoglu Z. Prevalence of feline retrovirus infections in Van cats. Bull Vet Inst Pulawy 2005; 49(4): 375-7.