Sepsisli Buzağılarda Ortalama Trombosit Hacmi ve Eritrosit Dağılım Hacminin Diyagnostik Önemi

Yıl 2024, , 194 - 201, 02.12.2024

Murat Uztimür

https://doi.org/10.32707/ercivet.1592078

Öz

İnsanlarda yapılan tıbbi çalışmalarda sepsis sırasında hematolojik parametrelerde anlamlı değişiklikler ortaya konmuş ve bu değişiklikler tanı ve prognoz amaçlı kullanılmıştır. Ancak veteriner hekimliği alanında hematolojik para-metrelerin tanı ve prognozdaki faydasına ilişkin çok az çalışma bulunmaktadır. Bu çalışmanın amacı buzağılarda sep-sisin belirlenmesinde ortalama trombosit hacmi (MPV), eritrosit dağılım genişliği-standart sapma/varyasyon katsayısı (RDW-SD/CV), trombosit dağılım genişliği (PDW) ve plateletkrit (PCT) parametrelerinin tanısal önem taşıyıp taşımadığını değerlendirmek ve ayrıca sepsis grubunda bu parametrelerin birbirleriyle olan ilişkilerini araştırmaktır. Çalışmaya sepsis tanısı konulan 45 buzağı dahil edildi. Sağlıklı olduğu belirlenen 15 buzağı kontrol grubunu oluşturdu. Sepsisli buzağılarda MPV, trombosit sayısı, RDW-SD, RDW-CV ve toplam lökosit sayısının kontrol grubuna göre an-lamlı derecede yüksek olduğu bulundu. Buzağılarda sepsis tanısı için yapılan ROC analizinde MPV'nin duyarlılığı 86.67, özgüllüğü 84.44, eğri altında kalan alan 0.91 ve kesme noktası değeri 5.95 fL olarak bulundu. Ayrıca diğer para-metreler için AUC değerleri sırasıyla PCT 0.79 (P=0.009), RDW-SD 0.68, RDW-CV 0.75 ve WBC 0.80 olarak bulundu. MPV ile diğer parametreler arasındaki korelasyon analizinde PCT 0.630, PDW 0.310, WBC 0.271, RDW-SD 0.383 ve RDW-CV 0.-643 arasında anlamlı ilişki olduğu belirlendi. Sonuç olarak MPV, ishalli yenidoğan buzağılarda sepsisin erken tespitinde iyi tanı performansı nedeniyle sepsisli buzağılarda yararlı bir biyobelirteç olabilir. Bu çalışmadaki sonuçların sepsis üzerine etkilerinin çok iyi belirlenebilmesi için gelecekte geniş örneklem sayılarına sahip popülasyon-larla çalışılması gerekmektedir.

Anahtar Kelimeler

Buzağı, ishal, MPV, RDW, sepsis

Diagnostic Significance of Mean Platelet Volume and Erythrocyte Distribution Width in Calves with Sepsis

Öz

Medical studies conducted on humans have revealed significant changes in hematological parameters dur-ing sepsis and used these changes for diagnostic and prognostic purposes. However, there are very few studies on the diagnostic and prognostic utility of hematological parameters in the field of veterinary medicine. The objective of this study was to assess whether the parameters mean platelet volume (MPV), erythrocyte distribution width standard devi-ation/coefficient of variation (RDW-SD/CV), platelet distribution width (PDW) and plateletcrit (PCT) hold diagnostic significance in identifying sepsis in calves, while also investigating the interrelationships of these parameters within these sepsis group. The study included 45 calves diagnosed with sepsis and healthy 15 calves as control group. In calves with sepsis, MPV, PCT, RDW-SD, RDW-CV and total leukocyte count were found to be significantly higher than the control group. In their analysis for the diagnosis of sepsis in calves, the sensitivity of MPV was 86.67, the specificity was 84.44, the area under the curve (AUC) was 0.91, and the cut-off point value was 5.95 fL. In addition, the AUC values for other parameters were found as PCT 0.79 (P=0.009), RDW-SD 0.68, RDW-CV 0.75 and WBC 0.80, respec-tively. In the correlation analysis between MPV and other parameters, it was determined that there was a significant relationship between PCT 0.630, PDW 0.310, WBC 0.271, RDW-SD 0.383 and RDW-CV 0.-643. In conclusion, MPV may be a useful biomarker in calves with sepsis due to its favorable diagnostic performance in the early detection of sepsis in new born calves with diarrhea. In order to determine the effects of the results in this study on sepsis very well, it is necessary to work with populations with large sample numbers in the future.

Anahtar Kelimeler

Calf, diarrhea, MPV, RDW, sepsis

Kaynakça

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