Tavşanlarda Bazı Antiglokomatöz İlaçların Göz İçi Basıncı Üzerine Etkileri*

Öz

Bu çalışmada, sağlıklı tavşanlara topikal olarak uygulanan travoprost, timolol ve travoprost/timolol kombinasyonunun göz içi basıncı (GİB) üzerine etkilerinin araştırılması amaçlandı. Çalışma materyalini 42 adet sağlıklı Yeni Zelanda ırkı tavşan oluşturdu. Çalışma materyalini oluşturan tavşanlar üç gruba ayrıldı. Grup 1’de travoprost, Grup 2’de timolol ve Grup 3’de travoprost/timolol kombinasyonu topikal olarak uygulandı. Tüm gruplarda sağ gözler deney grubu olarak belirlendi ve ilaç uygulaması yapıldı. Travoprost ve travoprost/timolol gruplarına günde bir defa saat 08:00’de, timolol grubuna ise günde iki defa 08:00 ve 20:00’de olmak üzere altı gün boyunca ilaç uygulamasına devam edildi. Uygulama döneminde GİB ölçümleri rebound tonometre kullanılarak saat 08:00, 10:00, 14:00 ve 20:00’de olmak üzere günde dört defa tekrarlandı. Aynı şekilde GİB değerleri uygulama öncesi üç gün ve ilaç uygulaması bittikten sonraki üç gün boyunca aynı saatlerde ölçüldü. Travoprost, timolol ve travoprost/timolol gruplarının GİB’e olan etkileri değerlendirildiğinde gruplar arasında istatistiksel olarak anlamlı fark gözlenmedi. Sonuç olarak travoprost, timolol ve travoprost/timolol gruplarının tavşanlarda GİB’e etkilerinin benzer olduğu, travoprost ve travoprost/timolol gruplarının timolole kıyasla daha uzun süre GİB düşüşü sağladığı, timololün ise diğer iki gruba göre daha hızlı bir GİB düşüşü gerçekleştirdiği tespit edildi.

Anahtar Kelimeler

• Glokom,göz içi basıncı,tavşan,timolol,travoprost

Effects of Some Topical Antiglaucomatous Drugs on Intraocular Pressure in Rabbits

Öz

To purpose of this study was to compare the effects of travoprost, timolol and travoprots/timolol combination on the intraocular pressure (IOP) of healthy rabbits. Forty two healthy New Zealand white rabbits were randomly divided into three groups to receive: travoprost (Group 1), timolol (Group 2), and combination of travoprost/timolol (Group 3). In all groups, the right eye was detected as the experimental group and drugs were instilled. Travoprost and travoprost/timolol was applied topically once a day at 8 AM whilst, timolol was given twice a day at 8 AM and 8 PM for six days. The IOP measurements were performed by using rebound tonometer at 8 AM, 10 AM, 2 PM and 8 PM during the six day treatment, three days before and three days after the treatment. There were no significant differences between the effects of travoprost, timolol and travoprost/timolol combination on IOP. As a result, the effects of travoprost, timolol and travoprost/timolol combination were similar in all groups, travoprost and travoprost/timolol groups provided longer IOP drop compared to timolol, timolol group exhibited a more rapid IOP drop than the other two groups.

Anahtar Kelimeler

• Glaucoma,intraocular pressure,rabbit,timolol,travoprost

Kaynakça

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