Bir Kedide Omuz Bölgesindeki Osteosarkom Olgusunun Histopatolojik Değerlendirilmesi

Öz

Bu çalışmanın materyalini, 8 yaşlı, dişi, melez bir kedinin sol skapulası üzerindeki, yaklaşık 5x3x2 cm boyutlarında

operasyon ile alınan bir kitle oluşturdu. Klinik muayenede, yeme ve içme durumunun normal olduğu ancak yürüme

esnasında omuz bölgesindeki kitleye bağlı gelişen topallıktan kaynaklanan bir yürüyüş bozukluğu görüldü.Operasyon

ile alınan kitlenin elastik kıvamda, kesit yüzünün gri-beyazımtırak renkte olduğu ve nekrotik alanların varlığı dikkati

çekti. Mikroskobik olarak, fibrosarkomatöz alanlar, solid tarzda yerleşim gösteren kıkırdak hücrelerine benzer, anaplastik

karakterde pleomorfik hücrelerden oluşan alanlar ve birbirleri ile kaynaşmış anaplastik karakterde osteoblastlardan

oluşan kemik trabekül yapıları gözlendi. Anamnez, klinik bulgular ve histopatolojik incelemeler sonucu olguya aşı ilişkili

osteosarkom tanısı konuldu.

Anahtar Kelimeler

• Aşı,kedi,osteosarkom

Histopathological Evaluation of Osteosarcoma of the Shoulder Region in a Cat

Öz

The material of this study consisted of a piece of mass which operatively removed from an eight year old,

female, half-breed cat. In the physical examination, the situation of drinking and eating were found normally. However

there was a walking disorder associated with shoulder lameness. The cross-section of this mass was in grey-white

colour, elastic consistency and there were some necrotic areas. Microscopically, mononuclear cell infiltration areas

which were situated around the fibrocytes, fibroblasts and collagen bundles or infiltrating in dermis were observed.

Bone trabecular were formed by anaplastic osteoblasts that fused with each other and also solid areas which

composed by chondrocytes like anaplastic pleomorphic cells were noticed. The history, clinical and histopathological

investigations revealed that the characteristic of mass was feline vaccine-associated osteosarcoma.

Anahtar Kelimeler

• Cat,osteosarcoma,vaccine

Kaynakça

1. Bergman PJ. Etiology of feline vaccine associated sarcomas: History and update. J Am Vet Med Assoc 1998; 213(10): 1424-5.
2. 2. Couto CG, Macy DW. Review of treatment options for vaccine associated feline sarcoma. J Am Vet Med Assoc 1998; 213(10): 1426-7.
3. 3. Couto SS, Griffey SM, Duarte PC, Madewell BR. Feline vaccine associated fibrosarcoma: Morphologic distinctions. Vet Pathol 2002; 39(1): 33-41.
4. 4. Dimopoulou M, Kirpensteijn J, Moens H, Kik M. Histologic prognosticators in feline osteosarcoma: A comparison with phenotypically similar canine osteosarcoma. Vet Surg 2008; 37(5): 466-71.
5. 5. Doddy FD, Glickman LT, Glickman NW, Janovitz EB. Feline fibrosarcomas at vaccination sites and non-vaccination sites. J Comp Pathol 1996; 114(2): 165-74.
6. 6. Ellis JA, Jackson ML, Bartsch RC, McGill LG, Martin KM, Trask BR, Haines DM. Use of immunohistochemistry and polymerase chain reaction for detection of oncornaviruses in formalin-fixed, paraffin-embedded fibrosarcomas from cats. J Am Vet Med Assoc 1996; 209(4): 767-71.
7. 7. Ford RB. Vaccines and vaccinations. The strategic issues. Vet Clin N Am Small Anim Pract 2001; 31(3): 439-53.
8. 8. Hauck M. Feline injection site sarcomas. Vet Clin N Am Small Anim Pract 2003; 33: 553-57.

9. 9. Hendrick MJ, Goldschmidt MH. Do injection site reactions induce fibrosarcomas in cats? J Am Vet Med Assoc 1991; 199(8): 968.
10. 10. Hendrick MJ, Kass PH, McGill LD, Tizard IR. Post vaccinal sarcomas in cats: Histology and immunohistochemistry. J Natl Cancer Inst 1994; 86: 341-3.
11. Hendrick MJ, Brooks JJ. Post vaccinal sarcomas in the cat: Histology and immunohistochemistry. Vet Pathol 1994; 31: 126-9.
12. 12. Hendrick MJ. Feline vaccine associated sarcomas: Current studies on pathogenesis. J Am Vet Med Assoc 1998; 213(10): 1425-6.
13. 13. Hershey AE, Sorenmo KU, Hendrick MJ, Shofer FS, Vail DM. Prognosis for presumed feline vaccine associated sarcoma after excision: 61 cases (1986–1996). J Am Vet Med Assoc 2000; 216(1): 58-61.
14. 14. Wilcock B, Wilcock A, Bottoms K. Feline postvaccinal sarcoma: 20 years later. Can Vet J 2012; 53(4): 430-4.
15. 15. Kass PH, Barnes Jr WG, Spangler WL, Chomel BB, Culbertson MR. Epidemiologic evidence for a causal relation between vaccination and fibrosarcoma tumorigenesis in cats. J Am Vet Med Assoc 1993; 203(3): 396-405.
16. 16. Kass PH, Spangler WL, Hendrick MJ, McGill LD, Esplin DG, Lester S, Slater M, EK Meyer, Boucher F, Peters EM, Gobar GG, Htoo T, Decile K. Multicenter case control study of risk factors associated with development of vaccine associated sarcomas in cats. J Am Vet Med Assoc 2003; 223(9): 1283-92.
17. 17. Kirpensteijn J. Feline injection site associated sarcoma: Is it a reason to critically evaluate our vaccination policies. Vet Microbiol 2006; 117(1): 59-65.
18. 18. Kutsal O, Vural Atalay S, Alçığır ME, Yumuşak N, Coşkan AS. Kedilerin aşı ilişkili yumuşak doku sarkomlarında patomorfolojik bulguların değerlendirilmesi. 10A338004 No’lu proje kesin raporu, Ankara: Ankara Üniversitesi, Bilimsel Araştırma Projeleri, 2012.
19. 19. Kutsal O, Kaya Ü, Vural S, Sağlam M. Köpek ve kedilerde 1986-2000 yılları arasında Ankara’da incelenen kemik tümörleri. Turk J Vet Anim Sci 2003; 27: 109-15.
20. 20. Macy DW, Hendrick MJ. The potential role of inflammation in the development of post vaccinal sarcomas in cats. Vet Clin N Am Small Anim Pract 1996; 26(1): 103-9.
21. Macy DW. Current understanding of vaccination site associated sarcomas in the cat. J Feline Med Surg 1999; 1(1): 15-21.
22. 22. McEntee MC, Page RL. Feline vaccine associated sarcomas. J Vet Intern Med 2001; 15(3): 176-82.
23. 23. Nieto A, Sánchez A, Martínez E, Rollán E. Immunohistochemical expression of p53, fibroblast growth factor-beta, and transforming growth factor-alpha in feline vaccine associated sarcomas. Vet Pathol 2003; 40(6): 651-8.