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Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues

Yıl 2018, , 230 - 237, 04.12.2018
https://doi.org/10.32707/ercivet.477307

Öz

This study was
conducted to evaluate the effects of pomegranate seed oil PSO on the oxidative
stress induced by pentachlorophenol PCP in rats. Fourty Sprague-Dawley, 4-5
months old, 300g male rats were used in this study. Rats were assigned to four
groups each containing 10 animals. First group was control group; no
administration was made to animals in this group. Second, third and fourth
groups were given PSO at a dose of 0.15 ml/kg bw, PCP at a dose of 40 mg/kg bw
and PSO at a dose of 0.15 ml/kg bw+PCP at a dose of 40 mg/kg bw orally by
gavage for 28 days, respectively. At the end of the study, brain, liver,
kidney, testicle and spleen samples were collected. Malondialdehyde (MDA) level
and catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase
(SOD) activities were measured in tissue samples.
PCP caused an increase of MDA level in brain,
kidney, liver and testicle; a decrease of CAT activity in liver and spleen; a
decrease of GSH-Px activity in brain and testicle and a decrease of SOD
activity in brain, liver and kidney compared to control group. When PSO+PCP
group compared to PCP group, MDA level decreased in brain, liver and testicle;
CAT activity increased in spleen; SOD activity increased in brain and kidney.
When compared to the control group and the group given PSO+PCP, the data of
PSO+PCP group were generally similar to the control group. As a result,
administration of PCP at the dose of 40 mg/kg bw for 28 days caused oxidative
stress and administration of PSO at the dose of 0.15 ml/kg bw alleviated
severity of PCP induced oxidative stress

Kaynakça

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Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

Zeynep Soyer Sarıca Bu kişi benim

Yayımlanma Tarihi 4 Aralık 2018
Gönderilme Tarihi 14 Ocak 2017
Kabul Tarihi 13 Mart 2018
Yayımlandığı Sayı Yıl 2018

Kaynak Göster

APA Soyer Sarıca, Z. (2018). Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 15(3), 230-237. https://doi.org/10.32707/ercivet.477307
AMA Soyer Sarıca Z. Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues. Erciyes Üniv Vet Fak Derg. Aralık 2018;15(3):230-237. doi:10.32707/ercivet.477307
Chicago Soyer Sarıca, Zeynep. “Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 15, sy. 3 (Aralık 2018): 230-37. https://doi.org/10.32707/ercivet.477307.
EndNote Soyer Sarıca Z (01 Aralık 2018) Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 15 3 230–237.
IEEE Z. Soyer Sarıca, “Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues”, Erciyes Üniv Vet Fak Derg, c. 15, sy. 3, ss. 230–237, 2018, doi: 10.32707/ercivet.477307.
ISNAD Soyer Sarıca, Zeynep. “Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 15/3 (Aralık 2018), 230-237. https://doi.org/10.32707/ercivet.477307.
JAMA Soyer Sarıca Z. Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues. Erciyes Üniv Vet Fak Derg. 2018;15:230–237.
MLA Soyer Sarıca, Zeynep. “Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, c. 15, sy. 3, 2018, ss. 230-7, doi:10.32707/ercivet.477307.
Vancouver Soyer Sarıca Z. Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues. Erciyes Üniv Vet Fak Derg. 2018;15(3):230-7.