Effect of Detomidine-Butorphanol-Ketamine and Atipamezole on Clinical, Cardiorespiratory, Haematological Parameters in Sheep

Yıl 2019, , 1 - 7, 25.03.2019

Gültekin Atalan

https://doi.org/10.32707/ercivet.538035

Cited By: 1

Öz

The aim of this study was to evaluate the sedative-anesthetic effects of detomidine (D) 30 µg/kg, intramuscular (IM), butorphanol (B) 0.2 mg/kg IM and ketamine (K) 5 mg/kg, IM combination in sheep. Five female and nine male healthy (1-2 years old) Akkaraman sheep were used as animal material. Detomidine and butorphanol were used to produce sedation. Ten minutes later K was administrated for anaesthesia. The anaesthetic effect of the drugs was reserved by atipamezole (AT) 30 µg/kg, IM administration at 30 minutes after K injection. The sedative effects of DB demerged in 3 minutes after injection and anaesthetic effects (by the lack of pain stimuli) were visible in 5 minutes after K injection. Heart rate, body temperature and amplitude P values significantly decreased until the administration of AT. Contrarily, respiratory rate, PR interval and R amplitude values increased during anesthesia. Partial venous oxygen pressure (PO2) and Partial venous carbon dioxide pressure (PCO2) values decreased during anaesthesia. There were no significant alterations seen for hematological parameters including hemoglobin (Hg), white blood cell (WBC), red blood cell (RBC) and hematocrit (Ht) values in sheep. As a result, BDK anaesthetic combination depresses the cardiorespiratoric system but produces adequate sedation and anaesthesia for sheep. AT can be safely used for this anaesthetic combination in sheep.

Anahtar Kelimeler

Butorphanol, detomidine, ketamine, sheep

Koyunlarda Detomidin-Butarfanol-Ketamin ve Atipamezol’ün Klinik, Kardiyorespiratorik, Hematolojik Parametreler Üzerine Etkileri

Öz

Bu çalışmanın amacı koyunlarda detomidin (D) 30µg/kg, intramüsküler (IM), butarfanol (B) 0.2 mg/kg, IM ve ketamin (K) 5 mg/kg, IM kombinasyonunun sedatif-anestezik etkilerinin değerlendirilmesidir. Beş dişi ve dokuz erkek (1 -2 yaşlı) Akkaraman koyunu çalışma materyali olarak kullanıldı. Detomidin ve butarfanolün sedasyon için enjeksiyonundan 10 dakika sonra ketamin anestezi amacı ile uygulandı. Uygulanan anesteziden 30 dakika sonunda atipamezol (AT) 30µg/kg IM uygulanarak kullanılan anaestezik ilaçların etkileri takip edildi. DB’ün sedatif etkisi enjeksiyonu takiben üç dakika sonra ve anestezik etki (ağrı uyaranlarına tepki kaybı) K enjeksiyonundan beş dakika sonra görüldü. Kalp atımı, vücut ısısı ve P amplitüt değerlerinde AT enjesinonu kadar önemli değişimler tespit edildi. Solunum sayısının aksine PR aralığı ve R amplitütleri anestezi sürecince azalma gösterdi. Parsiyel venöz oksijen basıncı (PO2) ve parsiyel venöz karbondioksit basıncı (PCO2) değerleri anestezi süresince azalış gösterdi. Hemoglobin (Hg), lökosit (WBC), eritrosit (RBC) ve hematokrit (Ht) değerlerini içeren hematolojik parametrelerde önemli değişim görülmedi. Sonuç olarak, BDK anestezi kombinasyonunun kardiyorespiratorik sistemi baskıladığı fakat koyunlar için yeterli derecede sedasyon ve anestezi sağladığı görüldü. AT’ün koyunlarda bu anestezi kombinasyonu için güvenli bir şekilde kullanılabileceği tespit edildi. 

Anahtar Kelimeler

Butarfanol, detomidin, ketamine, koyun

Kaynakça

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