Türkiye’de Yetiştirilen Holştayn Melezi Sığırlarda BLAD ve FXID Hastalıklarının Araştırılması

Öz

Bu çalışmada Türkiye’deki Holştayn melezlerinde Sığır Lökosit Bağlanma Eksikliği (BLAD) ve Faktör XI Eksikliği (FXID) kalıtsal hastalıklarına sebep olan mutant allellerin varlığının araştırılması amaçlanmıştır. Çalışmada toplam 48 baş sığır incelenmiştir. Yapılan moleküler analizlerden sonra incelenen melez sığırların birinin BLAD taşıyıcısı olduğu, FXID taşıyıcısı bireye rastlanılmadığı görülmüştür. Bu çalışma ile bu kalıtsal hastalıkların görüldüğü saf Holştayn ırkı dışında da BLAD ve FXID’ne sebep olan mutant allellerin varlığı araştırılmıştır. Böylece saf Holştayn ırkının haricinde de BLAD’a sebep olan mutant allelin varlığı ilk kez gösterilmiştir. Çalışma sonunda özellikle ıslah ve çevirme melezle-melerinde baba hat olarak kullanılacak damızlıkların, önemli kalıtsal hastalıklardan ari olduklarının kontrol edilmesi gerektiği sonucuna varılmıştır. Eğer bu konuda gerekli özen gösterilmez ise daha önce ırka özgü olduğu bilinen kalıtsal hastalıklara (BLAD, FIXID vb.) sebep olan mutant allellerin diğer sığır ırklarına da yayılabileceği sonucuna varılmıştır.

Anahtar Kelimeler

• BLAD
• FXID
• Holştayn melezi
• kalıtsal hastalık
• sığır

Investigation of FXID and BLAD Diseases in Holstein Crossbreed Cattles Reared in Turkey

Öz

This study aimed to investigate the presence of mutant alleles of Bovine Leukocyte Binding Deficiency (BLAD) and Factor XI Deficiency (FXID) hereditary diseases in Holstein crossbreeds reared in Turkey. Total of 48 cat-tle were examined in the study. After molecular analysis, it was observed that one of the crossbreed cattle examined was a BLAD carrier and no FXID carrier was found. With this study, the presence of mutant alleles that cause BLAD and FXID, except for the purebred Holstein in which these hereditary diseases are seen, was investigated. So, It was determined for the first time that the presence of mutant allele was also seen in crossbreed Holstein. At the end of the study, it was concluded that breeds to be used as sire lines in breeding and crossbreeding should be checked which they had free from important hereditary diseases. It is concluded that mutant alleles that cause hereditary diseases (BLAD, FIXID, etc.), which were previously known to be breed-specific, can spread to other cattle breeds if the neces-sary care is not taken.

Anahtar Kelimeler

• BLAD
• FXID
• Holstein crossbreed
• hereditary disease
• cattle

Kaynakça

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