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Ortak Ataları Olan İki Alman Holştayn Buzağıda Konjenital Damak-Dudak-Çene Yarığı ve Damak Yarığı Olgusu

Yıl 2017, Cilt: 14 Sayı: 1, 73 - 80, 15.04.2017

Öz

Ataları ortak olan iki buzağıda yapılan bu çalışma da sert damak kemiğine kadar uzanan bir damak yarığı olgusu sunulmaktadır. Birinci olgu, dişi bir aylık Alman Holştayn buzağı olup; dudak-damak ve çene yarığı ile beraber sağ rostral beyin hemisferi, bulbi olfactorii ve chiasma opticum’u ayrılmış olarak görüldü. Buna ek olarak, yüzünün sol tarafında bir meningosel mevcuttu. Buzağının dili sol tarafa aşağıya doğru asılı olarak duruyordu. İkinci olgu ise erkek Alman Holştayn buzağı olup iki aylık iken incelemesi yapıldı. Bu buzağı da ise tüm damak kemiği uzunluğu boyunca uzanan bir yarık damak (CP) olgusu gözlemlendi. Buzağılarda başka organ anomalileri görülmedi. Buzağılar farklı çiftliklerden gelmiştir. Her iki buzağıda da ağır seyreden bir bronkopnömoni tablosu bulunmaktadır. Buna ek olarak ikinci erkek buzağıda şiddetli bir ishal vardı. Her iki buzağınında bovine viral diare (BVD) virüs antikoru ve antijeni yönünden negatif olduğu belirlendi. Buzağıların ikisinde hem anne hem baba tarafından dört ortak atasının olduğu belirlendi. Ortak soydan gelen genetik faktörlerin her iki buzağıda gözlenen malformasyonların sebebi olabileceği düşünüldü.

Kaynakça

  • 1. Agerholm JS, Christensen K. Trisomy 22 in a calf. J Vet Med A 1993; 40(7): 576-81.
  • 2. Aksoy Ö, Kılıç E, Öztürk S, Özaydın İ, Sözmen M. Bir buzağıda median yüz yarığı anomalisi. Kafkas Üniv Vet Fak Derg 2004; 10(1): 109-11.
  • 3. Buck BC, Haist V, Ulrich R, Klein S, Kuiper H, Hewicker-Trautwein M, Beineke A, Distl O. Palatoschisis bei drei Deutschen Holstein Kälbern. Prakt Tierarzt 2009; 90(7): 660-6.
  • 4. Davis Rincker LE, Weber Nielsen MS, Chapin LT, Liesman JS, Van de Haar MJ. Effects of feeding prepubertal heifers a high energy diet for three, six or twelve weeks on feed intake, body growth, and fat deposition. J Dairy Sci 2008; 91(5): 1913-25.
  • 5. De Vries F, Starke A, Groeters S, Hewicker- Trautwein M, Schenk H, Distl O. Klinische und pathologisch-anatomische veränderungen infolge einer palatoschisis bei einem 23 Monate alten schwarzbunten Deutschen-Holstein-Rind. Tierarztl Prax 2007; 35(2): 117-24.
  • 6. Duchnese A, Eggen A. Radiation hybrid mapping of genes and newly identified microsatellites in candidate regions for bovine arthrogryposis-palatoschisis and progressive ataxia based on comparative data from man, mouse and rat. J Anim Breed Genet 2005; 122(1): 28-35.
  • 7. Gallagher DS, Lewis BC, De Donato M, Davies SK, Taylor JF, Edwards JF. Autosomal trisomy 20 (61,XX, +20) in a malformed bovine fetus. Vet Pathol 1999; 36(5): 448-51.
  • 8. Gethin SA. Arthrogryposis-palatoschisis in a Charolaise herd. Vet Rec 1977; 100(24): 41.
  • 9. Greene HJ, Leipold HW, Huston K, Noordsy JL, Dennis SM. Congenital defects in cattle. Irish Vet J 1973; 27: 37-45.
  • 10. Headrick JF, McAnulty JF. Reconstruction of a bilateral hypoplastic soft palate in a cat. J Am Anim Hosp Assoc 2004; 40(1): 86-90.
  • 11. Herzog A. Pareys Lexikon der Syndrome, Erb und Zuchtkrankheiten der Haus und Nutztiere. First Edition. Berlin: Parey-Buchverlag, 2001; pp. 214-15.
  • 12. Jurkiewicz MJ, Bryant DL. Cleft lip and palate in dogs: A progress report. Cleft Palate J 1968; 5(1): 30-6.
  • 13. Keeler RF, Crowe MW. Teratogenicity and toxicity of wild tree tobacco, Nicotiana glauca in sheep. Cornell Vet 1984; 74(1): 50-9.
  • 14. Knight AP, Walter RG. Plants associated with congenital defects and reproductive failure. Knight A.P, Walter RG. eds. In: A Guide to Plant Poisoning of Animals in North America. New York: Teton NewMedia, Jackson WY, 2004; pp. 278-91.
  • 15. Lee ST, Panter KE, Gay CC, Pfister JA, Ralphs MH, Gardner DR, Stegelmeier BL, Motteram ES, Cook D, Welch KD, Green BT, Davis TZ. Lupine-induced crooked calf disease: The last 20 years. Rangelands 2008; 30(6): 13-8.
  • 16. Leipold HW, Cates WF, Radostits OM, Howell WE. Spinal dysraphism, arthrogryposis and cleft palate in newborn Charolais calves. Can Vet J 1969; 10(10): 268-73.
  • 17. Leipold HW, Greene HJ, Huston K. Arthrogryposis and palatoschisis in neonatal Charolaise calves. Vet Med Sm Anim Clin 1973; 68: 1140-1146.
  • 18. Leipold HW, Huston K, Dennis SM. Bovine congenital defects. Adv Vet Sci Comp Med 1983; 27: 197-271.
  • 19. Leipold HW, Huston K, Hulbert LC, Guffy M, Dennis SM. Congenital syndrome in hereford calves with kyphoscoliosis, arthrogryposis and palatoschisis. Cornell Vet 1974; 64(1): 123-35.
  • 20. Logue DN, Breeze RG, Harvey MJA. Arthrogryposis-palatoschisis and a 1/29 translocation in a Charolaise herd. Vet Rec 1977; 100(24): 509-10.
  • 21. Mazaheri Y, Ranjbar R, Gahdiri AR, Afsahr FS, Nejad SG, Mahabady MK, Afrough M, Karampoor R, Tavakoli A. Cleft palate in a male water buffalo calf. Pak J Bio Sci 2007; 10(24): 4573-4.
  • 22. Milli ÜH, Hazıroğlu RM, Hazıroğlu R. Bir buzağıda artrogripozis, dudak-damak yarığı, kalp defektleri ve diğer malformasyonlar. Ankara Üniv Vet Fak Derg 1988; 35(2-3): 246-52.
  • 23. Minter LJ, Karlin WM, Hickey MJ, Byron CR. Surgical repair of a cleft palate in an American bison (Bison bison). J Zoo Wildlife Med 2010; 41(3): 562-6.
  • 24. Moritomo Y, Tsuda T, Miyamoto H. Craniofacial skeletal abnormalities in anomalous calves with clefts of the face. J Vet Med Sci 1999; 61(10): 1147-52.
  • 25. Oryan A, Shiran S, Samadian MR. Congenital craniofacial and skeletal defects with arthrogryposis in two newborn male Holstein Friesian calves. Comp Clin Pathol 2011; 20(1): 43-6.
  • 26. Panter KE, Gardner DR, Molyneux RJ. Teratogenic and fetotoxic effects of two piperidine alkaloid-containing lupines (L.Formosus and L.Arbustus) in cows. J Nat Toxins 1998; 7(2): 131-40.
  • 27. Panter KE, James LF, Gardner DR. Lupines, poison-hemlock and Nicotina spp: Toxicity and teratogenicity in livestock. J Nat Toxins 1999; 8(1): 117-34.
  • 28. Panter KE, Keeler RF, Bunch TD, Callan RJ. Congenital Skeletal malformations and cleft palate induced in goats by ingestion of Lupinus, Conium and Nicotiana species. Toxicon 1990; 28(12): 1377-85.
  • 29. Riley CB, Yovich JV, Bolton JR. Bilateral hypoplasia of the soft palate in a foal. Aust Vet J 1991; 68(5): 178-9.
  • 30. Setó-Salvia N, Stanier P. Genetics of cleft lip and/or cleft palate: Association with other common anomalies. Eur J Med Genet 2014; 57(8): 381-93.
  • 31. Singh UM, Little PB. Arthrogryposis and cleft palate in a Charolaise calf. Can Vet J 1972; 13(1): 21-4.
  • 32. Smolec O, Kos J, Vnuk D, Stejskal M, Bottegaro NB, Zobel R. Multiple congenital malformation in a Simmental female calf: a case report. Vet Med-Czech 2010; 55(4): 194-8.
  • 33. Thirunavukkarasu M, Balagopal R, Rajaraman S, Krishnakumar S, Chandrasekaran D, Selvavinayagi S. Palatoschisis in a calf. Indian Vet J 2006; 83(12): 435-6.
  • 34. Tunca R, Hazıroğlu R, Güvenç T, Kutsal O, Özsoy ŞY. Congenital cerebellar hypoplasia associated with BVD-MD virus infection in a naturally infected calf- a case report. Vet Arhiv 2006; 76(5): 453-60.
  • 35. Turhani D, Item CB, Watzinger E, Sinko K, Watzinger F, Lauer G, Ewers R. Mutation analysis of CLPTM 1 and PVRL 1 genes in patients with non-syndromic clefts of lip, alveolus and palate. J Craniomaxillofac Surg 2005; 33(5): 301-6.
  • 36. Washburn KE, Streeter RN. Congenital defects of the ruminant nervous system. Vet Clin Food Anim 2004; 20(2): 413-34.
  • 37. Wheat JD. Harelip in Shorthorn cattle. J Hered 1960; 51(2): 99-101.
  • 38. Wrede J, Schmidt T. Ein Management-Programm zur Optimierung der Inzucht in gefährdeten Populationen. Opti-Mate, Version 3.81. Second Edition. Hannover: Institut für Tierzucht und Vererbungsforschung der Stiftung Tierärztlichen Hochschule, 2003; pp. 1-20.
  • 39. Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM. DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet 2015; 24(15): 4340-52.

Congenital cleft lip-jaw-palate and cleft palate in German Holstein Calves with Common Ancestry

Yıl 2017, Cilt: 14 Sayı: 1, 73 - 80, 15.04.2017

Öz

In this study two calves with cleft palate extending over the full length of the osseous palate and common ancestors are presented. The first case, a female German Holstein calf was one month old at examination and showed a cleft palate, a right sided cleft lip and jaw, diverging rostral cerebral hemispheres, bulbi olfactorii and chiasma opticum and in addition, a meningocele on the left side of the face. The tongue of the calf hung down on left side. The second case was a male German Holstein, calf examined with an age of two months. This calf had a cleft palate (CP) extending over the entire length of the osseous palate. Other inborn organ defects could not be found in both calves. The calves originated from different dairy farms. Both calves suffered from a bronchopneumonia and in addition, the second case had a severe diarrhea. Both calves were negative for bovine viral diarrhea (BVD) virus antibody and antigen. Both calves had four common ancestors from either parent. The common ancestry may be indicative for genetic factors involved in the malformation observed in both cases.

Kaynakça

  • 1. Agerholm JS, Christensen K. Trisomy 22 in a calf. J Vet Med A 1993; 40(7): 576-81.
  • 2. Aksoy Ö, Kılıç E, Öztürk S, Özaydın İ, Sözmen M. Bir buzağıda median yüz yarığı anomalisi. Kafkas Üniv Vet Fak Derg 2004; 10(1): 109-11.
  • 3. Buck BC, Haist V, Ulrich R, Klein S, Kuiper H, Hewicker-Trautwein M, Beineke A, Distl O. Palatoschisis bei drei Deutschen Holstein Kälbern. Prakt Tierarzt 2009; 90(7): 660-6.
  • 4. Davis Rincker LE, Weber Nielsen MS, Chapin LT, Liesman JS, Van de Haar MJ. Effects of feeding prepubertal heifers a high energy diet for three, six or twelve weeks on feed intake, body growth, and fat deposition. J Dairy Sci 2008; 91(5): 1913-25.
  • 5. De Vries F, Starke A, Groeters S, Hewicker- Trautwein M, Schenk H, Distl O. Klinische und pathologisch-anatomische veränderungen infolge einer palatoschisis bei einem 23 Monate alten schwarzbunten Deutschen-Holstein-Rind. Tierarztl Prax 2007; 35(2): 117-24.
  • 6. Duchnese A, Eggen A. Radiation hybrid mapping of genes and newly identified microsatellites in candidate regions for bovine arthrogryposis-palatoschisis and progressive ataxia based on comparative data from man, mouse and rat. J Anim Breed Genet 2005; 122(1): 28-35.
  • 7. Gallagher DS, Lewis BC, De Donato M, Davies SK, Taylor JF, Edwards JF. Autosomal trisomy 20 (61,XX, +20) in a malformed bovine fetus. Vet Pathol 1999; 36(5): 448-51.
  • 8. Gethin SA. Arthrogryposis-palatoschisis in a Charolaise herd. Vet Rec 1977; 100(24): 41.
  • 9. Greene HJ, Leipold HW, Huston K, Noordsy JL, Dennis SM. Congenital defects in cattle. Irish Vet J 1973; 27: 37-45.
  • 10. Headrick JF, McAnulty JF. Reconstruction of a bilateral hypoplastic soft palate in a cat. J Am Anim Hosp Assoc 2004; 40(1): 86-90.
  • 11. Herzog A. Pareys Lexikon der Syndrome, Erb und Zuchtkrankheiten der Haus und Nutztiere. First Edition. Berlin: Parey-Buchverlag, 2001; pp. 214-15.
  • 12. Jurkiewicz MJ, Bryant DL. Cleft lip and palate in dogs: A progress report. Cleft Palate J 1968; 5(1): 30-6.
  • 13. Keeler RF, Crowe MW. Teratogenicity and toxicity of wild tree tobacco, Nicotiana glauca in sheep. Cornell Vet 1984; 74(1): 50-9.
  • 14. Knight AP, Walter RG. Plants associated with congenital defects and reproductive failure. Knight A.P, Walter RG. eds. In: A Guide to Plant Poisoning of Animals in North America. New York: Teton NewMedia, Jackson WY, 2004; pp. 278-91.
  • 15. Lee ST, Panter KE, Gay CC, Pfister JA, Ralphs MH, Gardner DR, Stegelmeier BL, Motteram ES, Cook D, Welch KD, Green BT, Davis TZ. Lupine-induced crooked calf disease: The last 20 years. Rangelands 2008; 30(6): 13-8.
  • 16. Leipold HW, Cates WF, Radostits OM, Howell WE. Spinal dysraphism, arthrogryposis and cleft palate in newborn Charolais calves. Can Vet J 1969; 10(10): 268-73.
  • 17. Leipold HW, Greene HJ, Huston K. Arthrogryposis and palatoschisis in neonatal Charolaise calves. Vet Med Sm Anim Clin 1973; 68: 1140-1146.
  • 18. Leipold HW, Huston K, Dennis SM. Bovine congenital defects. Adv Vet Sci Comp Med 1983; 27: 197-271.
  • 19. Leipold HW, Huston K, Hulbert LC, Guffy M, Dennis SM. Congenital syndrome in hereford calves with kyphoscoliosis, arthrogryposis and palatoschisis. Cornell Vet 1974; 64(1): 123-35.
  • 20. Logue DN, Breeze RG, Harvey MJA. Arthrogryposis-palatoschisis and a 1/29 translocation in a Charolaise herd. Vet Rec 1977; 100(24): 509-10.
  • 21. Mazaheri Y, Ranjbar R, Gahdiri AR, Afsahr FS, Nejad SG, Mahabady MK, Afrough M, Karampoor R, Tavakoli A. Cleft palate in a male water buffalo calf. Pak J Bio Sci 2007; 10(24): 4573-4.
  • 22. Milli ÜH, Hazıroğlu RM, Hazıroğlu R. Bir buzağıda artrogripozis, dudak-damak yarığı, kalp defektleri ve diğer malformasyonlar. Ankara Üniv Vet Fak Derg 1988; 35(2-3): 246-52.
  • 23. Minter LJ, Karlin WM, Hickey MJ, Byron CR. Surgical repair of a cleft palate in an American bison (Bison bison). J Zoo Wildlife Med 2010; 41(3): 562-6.
  • 24. Moritomo Y, Tsuda T, Miyamoto H. Craniofacial skeletal abnormalities in anomalous calves with clefts of the face. J Vet Med Sci 1999; 61(10): 1147-52.
  • 25. Oryan A, Shiran S, Samadian MR. Congenital craniofacial and skeletal defects with arthrogryposis in two newborn male Holstein Friesian calves. Comp Clin Pathol 2011; 20(1): 43-6.
  • 26. Panter KE, Gardner DR, Molyneux RJ. Teratogenic and fetotoxic effects of two piperidine alkaloid-containing lupines (L.Formosus and L.Arbustus) in cows. J Nat Toxins 1998; 7(2): 131-40.
  • 27. Panter KE, James LF, Gardner DR. Lupines, poison-hemlock and Nicotina spp: Toxicity and teratogenicity in livestock. J Nat Toxins 1999; 8(1): 117-34.
  • 28. Panter KE, Keeler RF, Bunch TD, Callan RJ. Congenital Skeletal malformations and cleft palate induced in goats by ingestion of Lupinus, Conium and Nicotiana species. Toxicon 1990; 28(12): 1377-85.
  • 29. Riley CB, Yovich JV, Bolton JR. Bilateral hypoplasia of the soft palate in a foal. Aust Vet J 1991; 68(5): 178-9.
  • 30. Setó-Salvia N, Stanier P. Genetics of cleft lip and/or cleft palate: Association with other common anomalies. Eur J Med Genet 2014; 57(8): 381-93.
  • 31. Singh UM, Little PB. Arthrogryposis and cleft palate in a Charolaise calf. Can Vet J 1972; 13(1): 21-4.
  • 32. Smolec O, Kos J, Vnuk D, Stejskal M, Bottegaro NB, Zobel R. Multiple congenital malformation in a Simmental female calf: a case report. Vet Med-Czech 2010; 55(4): 194-8.
  • 33. Thirunavukkarasu M, Balagopal R, Rajaraman S, Krishnakumar S, Chandrasekaran D, Selvavinayagi S. Palatoschisis in a calf. Indian Vet J 2006; 83(12): 435-6.
  • 34. Tunca R, Hazıroğlu R, Güvenç T, Kutsal O, Özsoy ŞY. Congenital cerebellar hypoplasia associated with BVD-MD virus infection in a naturally infected calf- a case report. Vet Arhiv 2006; 76(5): 453-60.
  • 35. Turhani D, Item CB, Watzinger E, Sinko K, Watzinger F, Lauer G, Ewers R. Mutation analysis of CLPTM 1 and PVRL 1 genes in patients with non-syndromic clefts of lip, alveolus and palate. J Craniomaxillofac Surg 2005; 33(5): 301-6.
  • 36. Washburn KE, Streeter RN. Congenital defects of the ruminant nervous system. Vet Clin Food Anim 2004; 20(2): 413-34.
  • 37. Wheat JD. Harelip in Shorthorn cattle. J Hered 1960; 51(2): 99-101.
  • 38. Wrede J, Schmidt T. Ein Management-Programm zur Optimierung der Inzucht in gefährdeten Populationen. Opti-Mate, Version 3.81. Second Edition. Hannover: Institut für Tierzucht und Vererbungsforschung der Stiftung Tierärztlichen Hochschule, 2003; pp. 1-20.
  • 39. Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM. DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet 2015; 24(15): 4340-52.
Toplam 39 adet kaynakça vardır.

Ayrıntılar

Bölüm Olgu Sunumu
Yazarlar

Zafer Usta Bu kişi benim

Ottmar Distl Bu kişi benim

Yayımlanma Tarihi 15 Nisan 2017
Gönderilme Tarihi 3 Nisan 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 14 Sayı: 1

Kaynak Göster

APA Usta, Z., & Distl, O. (2017). Ortak Ataları Olan İki Alman Holştayn Buzağıda Konjenital Damak-Dudak-Çene Yarığı ve Damak Yarığı Olgusu. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 14(1), 73-80.
AMA Usta Z, Distl O. Ortak Ataları Olan İki Alman Holştayn Buzağıda Konjenital Damak-Dudak-Çene Yarığı ve Damak Yarığı Olgusu. Erciyes Üniv Vet Fak Derg. Nisan 2017;14(1):73-80.
Chicago Usta, Zafer, ve Ottmar Distl. “Ortak Ataları Olan İki Alman Holştayn Buzağıda Konjenital Damak-Dudak-Çene Yarığı Ve Damak Yarığı Olgusu”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 14, sy. 1 (Nisan 2017): 73-80.
EndNote Usta Z, Distl O (01 Nisan 2017) Ortak Ataları Olan İki Alman Holştayn Buzağıda Konjenital Damak-Dudak-Çene Yarığı ve Damak Yarığı Olgusu. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 14 1 73–80.
IEEE Z. Usta ve O. Distl, “Ortak Ataları Olan İki Alman Holştayn Buzağıda Konjenital Damak-Dudak-Çene Yarığı ve Damak Yarığı Olgusu”, Erciyes Üniv Vet Fak Derg, c. 14, sy. 1, ss. 73–80, 2017.
ISNAD Usta, Zafer - Distl, Ottmar. “Ortak Ataları Olan İki Alman Holştayn Buzağıda Konjenital Damak-Dudak-Çene Yarığı Ve Damak Yarığı Olgusu”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 14/1 (Nisan 2017), 73-80.
JAMA Usta Z, Distl O. Ortak Ataları Olan İki Alman Holştayn Buzağıda Konjenital Damak-Dudak-Çene Yarığı ve Damak Yarığı Olgusu. Erciyes Üniv Vet Fak Derg. 2017;14:73–80.
MLA Usta, Zafer ve Ottmar Distl. “Ortak Ataları Olan İki Alman Holştayn Buzağıda Konjenital Damak-Dudak-Çene Yarığı Ve Damak Yarığı Olgusu”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, c. 14, sy. 1, 2017, ss. 73-80.
Vancouver Usta Z, Distl O. Ortak Ataları Olan İki Alman Holştayn Buzağıda Konjenital Damak-Dudak-Çene Yarığı ve Damak Yarığı Olgusu. Erciyes Üniv Vet Fak Derg. 2017;14(1):73-80.