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Boynuzsuzlaştırılan Holstein Düvelerde bazı Hemostatik Değişkenler Üzerine Meloksikam ve Flunixin Meglumin Etkinliğinin Karşılaştırılması

Yıl 2017, Cilt: 14 Sayı: 2, 87 - 91, 15.08.2017

Öz

Boynuz köreltme sığırlar için stresli/ağrılı tepki eşliğinde fizyolojik, davranışsal ve nöroendokrin değişikliklere neden olur. Non-steroid anti-inflamatuar ilaçlar boynuz ile bağlantılı ağrı tepkisini azaltır; Ancak, hemostaz üzerindeki etkinlikleri iyi bilinmemektedir. Ayrıca, sığır hemostatik profili pıhtılaşma değişiklikleri veya işlev bozukluğunu önlemek amacıyla ameliyat öncesi göz önüne alınmalıdır. Bu çalışmada, boynuzsuzlaştırma yapılan Holstein düvelerde meloksi-kam ve fluniksin meglumin uygulamasının pıhtılaşma profillerine etkinliğini değerlendirmek amacıyla yapılmıştır. Düve-lere (n=14) boynuzsuzlaştırma öncesi meloksikam (0.5 mg/kg, i.v.) veya fluniksin meglumin (2.2 mg/kg, i.v.) tek doz halinde uygulandı. Fibrinojen (F), protrombin zamanı (PT) ve aktive edilmiş kısmi tromboplastin zamanı (APTT) boy-nuzsuzlaştırmadan önce (0. dakika) ve boynuzsuzlaştırma sonrası 90 dakika olarak belirlendi. Meloksikam uygulanan düvelerde fibrinojen konsantrasyonu (ortalama ± SEM) başlangıç değerlerinin (212.86±8.13 mg/dl) aksine 90 dakika sonra (238.83±14,22 mg/dL) anlamlı artış gösterdi (P<0.05). Diğer pıhtılaşma parametrelerinde önemli bir değişiklik tespit edilmedi. Boynuz kesimi uygulanan düvelerde meloksikam ve fluniksin meglumin’in tek doz intravenöz uygulama-larının seçilen hemostatik değişkenlerde önemli değişikliklere neden olmadığı gözlendi.

Kaynakça

  • 1. Botting RM. Cyclooxygenase: Past, present and future. A tribute to John R. Vane (1927–2004). J Therm Biol 2006; 1-2(31): 208-19. 2. Coetzee JF, Mosher RA, KuKanich B, Gehring R, Robert B, Reinbold B, White BJ. Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves fol-lowing scoop dehorning without local anes-thesia. BMC Vet Res 2012; 8(153): 1-15. 3. Faulkner PM, Weary DM. Reducing pain after dehorning in dairy calves. J Dairy Sci 2000; 83(9): 2037-41. 4. Ferreira SH, Moncada S, Vane JR. Prosta-glandins and the mechanism of analgesia produced by aspirin - like drugs. Br J Phar-macol 1997; 120(4): 401-12. 5. Ferreira SH, Moncada S, Vane JR. Further experiments to establish that the analgesic action of aspirin - like drugs depends on the inhibition of prostaglandin biosynthesis. Br J Pharmacol 1973; 47(3): 629-30. 6. Fiorucci S, Meli R, Bucci M, Cirino G. Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy. Biochem Pharmacol 2001; 62(11): 1433-8. 7. Gavotto AC, Palma JA, Villagra SB. Effectsof indomethacin on plasma fibrinogen levels in rats with tissue injury. Arch Int Pharmaco-dyn Ther 1985; 274(2): 320-7. 8. Gavotto AC, Palma JA, Villagra SB. Role of histamine on plasma fibrinogen levels in rats with surgical injury (laparotomy). Arch Int Physiol Biochim 1985; 93(3): 175-9. 9. Guadiz G, Sporn LA, Simpsons Haidaris P. Thrombin cleavage independent deposition of fibrinogen in extracellular matrices. Blood 1997; 90(7): 2644-53. 10. Heinrich A. An investigation of meloxicam for relief of pain associated with dehorning of dairy calves, Master of Science thesis, University of Guelph, Guelph, 2007. 11. Heinrich A, Duffield TF, Lissemore KD, Mill-man ST. The effect of meloxicam on behav-ior and pain sensitivity of dairy calves follow-ing cautery dehorning with a local anesthet-ic. J Dairy Res 2010; 93(6): 2450-7. 12. Heinrich A, Duffield TF, Lissemore KD, Squires EJ, Millman ST. The impact of meloxicam on postsurgical stress associat-ed with cautery dehorning. J Dairy Res 2009; 92(2): 540-7. 13. Huber J, Arnholdt T, Möstl E, Gelfert CC, Drillich M. Pain management with flunixin meglumine at dehorning of calves. J Dairy Res 2013; 96(1): 132-40. 14. Kay-Mugford P, Benn SJ, LaMarre J, Con-lon P. In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase ac-tivity in dogs. Am J Vet Res 2000; 61(7): 802-10. 15. Laven R, Chambers P, Stafford K. Using non-steroidal anti-inflammatory drugs around calving: Maximizing comfort, produc-tivity and fertility. Vet J 192(1):8-12. 16. Masini AP, Poppenga RH, Sweeney RW. Disposition of flunixin meglumine injectable preparation administered orally to healthy horses. J Vet Pharmacol Ther 2004; 27(3):183-6. 17. Mathews KA. Nonsteroidal anti-inflamema tory analgesics: a review of current practice. J Vet Emerg Crit Care 2002; 2(12): 89-97. 18. Metz SA. Anti-inflammatory agents as inhibi-tors of prostaglandins synthesis in man. Med Clin North Am 1981; 65(4): 713-57. 19. M’hamdi N, Darej C, Bouraoui R. Animal welfare issues concerning procedures of calves dehorning. App Sci Report 2013; 4(3): 234-40. 20. Moya M, Campana V, Gavotto A, Spitale L, Simes J, Palma J. Hyperfibrinogenemia in rats treated with meloxicam. Jpn Heart J 2002; 43(5): 559-66. 21. Murata H, Shimada N, Yoshioka M. Current research on acute phase proteins in veteri-nary diagnosis: An overview. Vet J 2004; 168(1): 28-40. 22. Newton HP, O’Connor AM. The economics of pain management. Vet Clin North Am Food Anim Pract 2013; 29(1): 229-50. 23. Palma JA, Enders JE, Paglini de Oliva PA. Effects of epinephrine on plasma fibrinogen levels in rats submitted to tissue injury. Ex-perientia 1981; 37(7): 780-1. 24. Palma JA, Gavotto AC, Villagra SB. Effects of the administration of progesterone and adrenal medullectomy on the plasma fibrino-gen levels in rats with surgical injury (laparotomy). Arch Int Physiol Biochim 1983a; 91(2): 81-5. 25. Palma JA, Gavotto AC, Villagra SB. Effects of diethylstilbestrol 17 beta estradiol and progesterone on plasma fibrinogen in rats submitted to tissue injury (laparotomy). J Trauma Acute Care Surg 1983b; 23(2): 132-5. 26. Petrie NJ, Mellor DJ, Stafford KJ, Bruce RA, Ward RN. Cortisol responses of calves to two methods of disbudding used with or without local anaesthetic. N Z Vet J 1996; 44(1): 9-14. 27. Razaahmad A. Fibrinogen a diagnostic marker for early ischemia. Biotech 1994; 69(5): 268-72. 28. Stock ML, Baldridge SL, Griffin D, Coetzee JF. Bovine dehorning, assessing pain and providing analgesic management. Vet Clin North Am Food Anim Pract 2013; 29(1): 103-33. 29. Taketo MM. Cyclooxygenase-2 inhibitors in tumorigenesis. J Natl Cancer Inst 1998; 90(21): 1609-20. 30. Van Engen NK, Stock ML, Engelken T, Vann RC, Wulf LW, Karriker LA, Busby WD, Lakritz J, Carpenter AJ, Bradford BJ, Hsu WH, Wang C, Coetzee JF. Impact of oral meloxicam on circulating physiological bi-omarkers of stress and inflammation in beef steers after long-distance transportation. J Anim Sci 2014; 92(2): 498-510. 31. Van Nydam D, Nydam CW. Dehorning/Cornuectomy. Fubini S, Ducharme N. eds. In: Farm Animal Surgery. Missouri: Elsevier, 2004; pp.132-8.

Comparison of the Efficacies of Meloxicam and Flunixin Meglumine on some Haemostatic Variables in Dehorned Holstein Heifers

Yıl 2017, Cilt: 14 Sayı: 2, 87 - 91, 15.08.2017

Öz

Dehorning may cause physiologic, behavioral and neuroendocrine alterations accompanied by a stressful/painful response among cattle. Non-steroidal anti-inflammatory drugs mitigate the pain response related to dehorning; however, their efficacy on hemostasis is not well-known. Moreover, the haemostatic profile of cattle has to be taken into consideration prior to surgery in order to prevent alterations or dysfunction in coagulation. This study was conduct-ed to evaluate the efficacy of meloxicam and flunixin meglumine administration on the coagulation profiles of Holstein heifers subjected to dehorning. Heifers (n=14) were administered either meloxicam (0.5 mg/kg, i.v.) or flunixin meglu-mine (2.2 mg/kg, i.v.) in a single dose prior to dehorning. Fibrinogen (F), prothrombin time (PT), and activated partial thromboplastin time (APTT) were determined prior to dehorning (time 0) and 90 minutes after administration. Fibrino-gen concentration (mean ± SEM) in the heifers that received meloxicam was significantly increased (P<0.05) 90 minutes after administration (238.83±14.22 mg/dL) in contrast to initial values (212.86±8.13 mg/dL). Significant differ-ences were not detected in other coagulation panel parameters at sampling times. Intravenous administration of single dose meloxicam or flunixin meglumine was determined not to cause significant changes of selected haemostatic varia-bles in heifers subjected to dehorning.

Kaynakça

  • 1. Botting RM. Cyclooxygenase: Past, present and future. A tribute to John R. Vane (1927–2004). J Therm Biol 2006; 1-2(31): 208-19. 2. Coetzee JF, Mosher RA, KuKanich B, Gehring R, Robert B, Reinbold B, White BJ. Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves fol-lowing scoop dehorning without local anes-thesia. BMC Vet Res 2012; 8(153): 1-15. 3. Faulkner PM, Weary DM. Reducing pain after dehorning in dairy calves. J Dairy Sci 2000; 83(9): 2037-41. 4. Ferreira SH, Moncada S, Vane JR. Prosta-glandins and the mechanism of analgesia produced by aspirin - like drugs. Br J Phar-macol 1997; 120(4): 401-12. 5. Ferreira SH, Moncada S, Vane JR. Further experiments to establish that the analgesic action of aspirin - like drugs depends on the inhibition of prostaglandin biosynthesis. Br J Pharmacol 1973; 47(3): 629-30. 6. Fiorucci S, Meli R, Bucci M, Cirino G. Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy. Biochem Pharmacol 2001; 62(11): 1433-8. 7. Gavotto AC, Palma JA, Villagra SB. Effectsof indomethacin on plasma fibrinogen levels in rats with tissue injury. Arch Int Pharmaco-dyn Ther 1985; 274(2): 320-7. 8. Gavotto AC, Palma JA, Villagra SB. Role of histamine on plasma fibrinogen levels in rats with surgical injury (laparotomy). Arch Int Physiol Biochim 1985; 93(3): 175-9. 9. Guadiz G, Sporn LA, Simpsons Haidaris P. Thrombin cleavage independent deposition of fibrinogen in extracellular matrices. Blood 1997; 90(7): 2644-53. 10. Heinrich A. An investigation of meloxicam for relief of pain associated with dehorning of dairy calves, Master of Science thesis, University of Guelph, Guelph, 2007. 11. Heinrich A, Duffield TF, Lissemore KD, Mill-man ST. The effect of meloxicam on behav-ior and pain sensitivity of dairy calves follow-ing cautery dehorning with a local anesthet-ic. J Dairy Res 2010; 93(6): 2450-7. 12. Heinrich A, Duffield TF, Lissemore KD, Squires EJ, Millman ST. The impact of meloxicam on postsurgical stress associat-ed with cautery dehorning. J Dairy Res 2009; 92(2): 540-7. 13. Huber J, Arnholdt T, Möstl E, Gelfert CC, Drillich M. Pain management with flunixin meglumine at dehorning of calves. J Dairy Res 2013; 96(1): 132-40. 14. Kay-Mugford P, Benn SJ, LaMarre J, Con-lon P. In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase ac-tivity in dogs. Am J Vet Res 2000; 61(7): 802-10. 15. Laven R, Chambers P, Stafford K. Using non-steroidal anti-inflammatory drugs around calving: Maximizing comfort, produc-tivity and fertility. Vet J 192(1):8-12. 16. Masini AP, Poppenga RH, Sweeney RW. Disposition of flunixin meglumine injectable preparation administered orally to healthy horses. J Vet Pharmacol Ther 2004; 27(3):183-6. 17. Mathews KA. Nonsteroidal anti-inflamema tory analgesics: a review of current practice. J Vet Emerg Crit Care 2002; 2(12): 89-97. 18. Metz SA. Anti-inflammatory agents as inhibi-tors of prostaglandins synthesis in man. Med Clin North Am 1981; 65(4): 713-57. 19. M’hamdi N, Darej C, Bouraoui R. Animal welfare issues concerning procedures of calves dehorning. App Sci Report 2013; 4(3): 234-40. 20. Moya M, Campana V, Gavotto A, Spitale L, Simes J, Palma J. Hyperfibrinogenemia in rats treated with meloxicam. Jpn Heart J 2002; 43(5): 559-66. 21. Murata H, Shimada N, Yoshioka M. Current research on acute phase proteins in veteri-nary diagnosis: An overview. Vet J 2004; 168(1): 28-40. 22. Newton HP, O’Connor AM. The economics of pain management. Vet Clin North Am Food Anim Pract 2013; 29(1): 229-50. 23. Palma JA, Enders JE, Paglini de Oliva PA. Effects of epinephrine on plasma fibrinogen levels in rats submitted to tissue injury. Ex-perientia 1981; 37(7): 780-1. 24. Palma JA, Gavotto AC, Villagra SB. Effects of the administration of progesterone and adrenal medullectomy on the plasma fibrino-gen levels in rats with surgical injury (laparotomy). Arch Int Physiol Biochim 1983a; 91(2): 81-5. 25. Palma JA, Gavotto AC, Villagra SB. Effects of diethylstilbestrol 17 beta estradiol and progesterone on plasma fibrinogen in rats submitted to tissue injury (laparotomy). J Trauma Acute Care Surg 1983b; 23(2): 132-5. 26. Petrie NJ, Mellor DJ, Stafford KJ, Bruce RA, Ward RN. Cortisol responses of calves to two methods of disbudding used with or without local anaesthetic. N Z Vet J 1996; 44(1): 9-14. 27. Razaahmad A. Fibrinogen a diagnostic marker for early ischemia. Biotech 1994; 69(5): 268-72. 28. Stock ML, Baldridge SL, Griffin D, Coetzee JF. Bovine dehorning, assessing pain and providing analgesic management. Vet Clin North Am Food Anim Pract 2013; 29(1): 103-33. 29. Taketo MM. Cyclooxygenase-2 inhibitors in tumorigenesis. J Natl Cancer Inst 1998; 90(21): 1609-20. 30. Van Engen NK, Stock ML, Engelken T, Vann RC, Wulf LW, Karriker LA, Busby WD, Lakritz J, Carpenter AJ, Bradford BJ, Hsu WH, Wang C, Coetzee JF. Impact of oral meloxicam on circulating physiological bi-omarkers of stress and inflammation in beef steers after long-distance transportation. J Anim Sci 2014; 92(2): 498-510. 31. Van Nydam D, Nydam CW. Dehorning/Cornuectomy. Fubini S, Ducharme N. eds. In: Farm Animal Surgery. Missouri: Elsevier, 2004; pp.132-8.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Bölüm Araştırma Makalesi
Yazarlar

İbrahim Akın

Umit Karademir Bu kişi benim

Yayımlanma Tarihi 15 Ağustos 2017
Gönderilme Tarihi 20 Eylül 2017
Kabul Tarihi 11 Ekim 2016
Yayımlandığı Sayı Yıl 2017 Cilt: 14 Sayı: 2

Kaynak Göster

APA Akın, İ., & Karademir, U. (2017). Boynuzsuzlaştırılan Holstein Düvelerde bazı Hemostatik Değişkenler Üzerine Meloksikam ve Flunixin Meglumin Etkinliğinin Karşılaştırılması. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 14(2), 87-91.
AMA Akın İ, Karademir U. Boynuzsuzlaştırılan Holstein Düvelerde bazı Hemostatik Değişkenler Üzerine Meloksikam ve Flunixin Meglumin Etkinliğinin Karşılaştırılması. Erciyes Üniv Vet Fak Derg. Ağustos 2017;14(2):87-91.
Chicago Akın, İbrahim, ve Umit Karademir. “Boynuzsuzlaştırılan Holstein Düvelerde Bazı Hemostatik Değişkenler Üzerine Meloksikam Ve Flunixin Meglumin Etkinliğinin Karşılaştırılması”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 14, sy. 2 (Ağustos 2017): 87-91.
EndNote Akın İ, Karademir U (01 Ağustos 2017) Boynuzsuzlaştırılan Holstein Düvelerde bazı Hemostatik Değişkenler Üzerine Meloksikam ve Flunixin Meglumin Etkinliğinin Karşılaştırılması. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 14 2 87–91.
IEEE İ. Akın ve U. Karademir, “Boynuzsuzlaştırılan Holstein Düvelerde bazı Hemostatik Değişkenler Üzerine Meloksikam ve Flunixin Meglumin Etkinliğinin Karşılaştırılması”, Erciyes Üniv Vet Fak Derg, c. 14, sy. 2, ss. 87–91, 2017.
ISNAD Akın, İbrahim - Karademir, Umit. “Boynuzsuzlaştırılan Holstein Düvelerde Bazı Hemostatik Değişkenler Üzerine Meloksikam Ve Flunixin Meglumin Etkinliğinin Karşılaştırılması”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 14/2 (Ağustos 2017), 87-91.
JAMA Akın İ, Karademir U. Boynuzsuzlaştırılan Holstein Düvelerde bazı Hemostatik Değişkenler Üzerine Meloksikam ve Flunixin Meglumin Etkinliğinin Karşılaştırılması. Erciyes Üniv Vet Fak Derg. 2017;14:87–91.
MLA Akın, İbrahim ve Umit Karademir. “Boynuzsuzlaştırılan Holstein Düvelerde Bazı Hemostatik Değişkenler Üzerine Meloksikam Ve Flunixin Meglumin Etkinliğinin Karşılaştırılması”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, c. 14, sy. 2, 2017, ss. 87-91.
Vancouver Akın İ, Karademir U. Boynuzsuzlaştırılan Holstein Düvelerde bazı Hemostatik Değişkenler Üzerine Meloksikam ve Flunixin Meglumin Etkinliğinin Karşılaştırılması. Erciyes Üniv Vet Fak Derg. 2017;14(2):87-91.