Recent Advances in the Application Superovulation in Cattle

Yıl 2019, Cilt: 16 Sayı: 3, 198 - 203, 01.12.2019

Uğur Kara , Tayfur Bekyürek

https://doi.org/10.32707/ercivet.648580

Öz

The purpose
of superovulation applications is to obtain the maximum number of fertilization
and transferable embryos. Differences
in ovarian functional responses in superovulated cattle and the
unpredictability of this condition negatively affect the profitability and
applicability of embryo transfer programs. Differential functional responses of donors to
superovulatory applications are due to differences in the stages of follicular
development on the ovaries at the onset of gonadotropin administration. The traditional superovulation methods which
initiated to be applied between 8-12 days of oestrus cycle the important
disadvantages such as the inability of the donors to get into practice at the
same time and at the same time as the cycle, have led practitioners to search
for alternative superovulation methods. Superovulation methods developed rapidly after the
use of purified pituitary extracts and intravaginal devices of progesterone
release. Superovulation can be applied to desired number of
donor animals at any time during the cycle determination of ovarian follicul
dynamic, controlling the exogenous follicular wave appearance and the
implementation of synchronization of the follicular wave based on removal of
the dominant follicle suppressive effect. Furthermore, the results obtained from these new
practical approaches developed are comparable to those obtained by traditional
superovulation methods. The
development of protocols in which simplified and optimal number of transferable
embryos can be obtained will contribute positively to the cost and
applicability of embryo production and transfer studies.

Anahtar Kelimeler

Folliculer wave, FSH, GnRH, estradiol, superovulation

İneklerde Süperovulasyon Uygulamalarında Son Gelişmeler

Öz

Süperovulasyon uygulamalarının amacı maksimum
sayıda fertilizasyon ve transfer edilebilir embriyo elde etmektir. Süperovulasyon
uygulanan sığırlarda ovaryum fonksiyonel cevabındaki farklılıklar ve bu durumun
önceden tahmin edilememesi embriyo transfer programlarının karlılığını ve uygulanabilirliğini
olumsuz etkilemektedir. Donörlerin süperovulasyon uygulamalarına verdikleri
fonksiyonel yanıt farklılıkları gonadotropin uygulamasının başlangıcında
ovaryumlar üzerindeki foliküler gelişim aşamalarındaki farklılıklardan
kaynaklanmaktadır. Östrus siklusunun 8-12. günleri arasında uygulamaya
başlanılan geleneksel süperovulasyon yöntemlerinin yoğun iş gücü gereksinimi ve
donörlerin aynı zaman ve siklus aşamasında uygulamaya alınamaması gibi önemli
dezavantajları uygulayıcıları alternatif süperovulasyon yöntemlerinin
geliştirilmesi arayışına yöneltmiştir.  Süperovulasyon
yöntemleri saflaştırılmış hipofiz ekstraktları ve progesteron salınımı yapan
intravaginal araçların kullanılmaya başlamasından sonra hızla gelişim
göstermiştir. Ovaryumun folikül dinamiğinin belirlenmesi, foliküler dalga
oluşumunun ekzojen kontrolü ve dominant folikülün baskılayıcı etkisinin ortadan
kaldırılmasını temel alan foliküler dalga senkronizasyonu uygulamalarının
gerçekleştirilmesi ile siklusun herhangi bir döneminde istenilen sayıda donör
hayvana aynı zamanda süperovulasyon uygulanabilmektedir. Ayrıca geliştirilen bu
yeni pratik yaklaşımlardan elde edilen sonuçlar geleneksel süperovulasyon
yöntemleri ile elde edilen sonuçlarla karşılaştırılabilir düzeydedir. Sadeleştirilmiş
ve optimum sayıda transfer edilebilir embriyo elde edilebilen protokollerin geliştirilmesi
embriyo üretimi ve transferi çalışmalarının maliyeti ve uygulanabilirliği
üzerine olumlu katkı sağlayacaktır.  

Anahtar Kelimeler

Foliküler dalga, FSH, GnRH, östradiol, süperovulasyon

Kaynakça

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