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Phytoestrogens and Effects on Health

Yıl 2005, Cilt: 2 Sayı: 2, 91 - 95, 01.06.2005

N. İnanç Ş. Tuna

Öz

-

Anahtar Kelimeler

Fitoöstojenler sağlık

Kaynakça

  • Albertazzi P, Purdie WD, 2002. The nature and utility of the phytoestrogens: a review of the evidence. Maturitas, 173–185.
  • Alekel DL, Germain AS, Peterson CT, Hanson KB, Steward JW, Toda T, 2000. İsoflavone rich soy protein isolate attenuates bone loss in the lumbar spine of premenopausal women. Am J Clin Nutr., 72: 844–852.
  • Baysal A, 2002. İşlevsel besinler. Beslenme, 9. Baskı. Ankara: Hatiboğlu Yayınevi, s. 347– 354.
  • Bingham SA, Atkinson C, Liggins J, Bluck L, Coward A, 1998. Phyto-oestrogens: where are we now? Br J Nutr, 79: 393–406.
  • Boker KL, Schouw DT, Grabbee ED, Reeters HMP, 2004. Dietary phytoestrogens and breast cancer risk. Am J Clin Nutr., 79: 282– 288.
  • Büyüktuncer Z, 2000. Fitoöstrojenlerin meno- poz üzerine etkileri. IV. Uluslararası Beslen- me ve Diyetetik Kongresi Bildiriler Kitabı, 67.
  • Cornwell T, Cohick W, Raskin I, 2004. Dietary phytoestrogens and health. Phytochemistry, 65: 995–1016.
  • Fritz WA, Wang j, Lamartiniere CA, 1998. Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Am J Carcinogenesis. 2151–2158.
  • Gambacciani M, Ciaponi M, Cappagli B, Piaggesi l, Genazzani AR, 1997. Effects of combined low dose of the isoflavone derivate ipriflavone and estrogen replacement on bone mineral postmenopausal women. Maturitas, 28: 75– 81. metabolism in
  • Golgberg G. 2001. Plants: Diet and Health. British Publishing, pp. 138–146. Blackwell
  • Magee JP, Rowland R, 2004. Phyto- oestrogens, their mechanism of action; current evidence for e role in breast and prostate cancer. Br J Nutr., 91: 513–531.
  • Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, D’Anna R, Corrado F, Pizzoleo MA, Cincotta M, Altavilla D, Ientile R, Squadrito , 2002. Effects of genistein and hormone-replacement therapy on bone loss in early post-menopausal women: a randomized double-blind placebo-controlled study. J Bone Miner Res., 17: 1904–1912.
  • Rowland I, Faughan M, Hoey L, Wahala K, 2003. Bioavailability of phyto-oestrogens. Br J Nutr, 89 (supp 1):pp 45–58.
  • Schmitt E, Lehmann M, Metzler M, Stoper H, 2002. Hormonal and genotoxic activity of resveratrol. Toxicology Letters.136: 133-142.
  • Stopper H, Schmitt E, Kobras K, 2005. Genotoxicity of phytoestrogens. Research. 574: 139-155. Mutation
  • Ulusoylu M, 2004. İzoflavonlar. Marmara Üniversitesi Eczacılık Fakültesi Farmakognozi ABD.www.nutrisyon.com.
  • Virgilio DLA, Iwami K, Watjen W, Kohl R, Degen GH, 2004. Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells. Toxicology Letters. 151: 151-162.
  • Walter F, Ulrich S, Stein J, 2004. Molecular mechanisms of the chemopreventive effects of resveratrol and its anologs in colorectal cancer: key role of polyamines? J Nutr., 134: 3219-3222.
  • Wangen KE, Duncan AM, Kurzer MS, 2001. Soy isoflavones improve plasma lipids in normocholesterolemic hypercholesterolemic women. Am J Clin Nutr., 73: 225-31. postmenapausal
  • Wilson T, Temple NJ, 2001. Health benefits of soy isoflavones. Nutritional Health Strategies for Disease Prevention. Humana Press Inc., Totowa. pp. 75-85.
  • ipriflavone and estrogen replacement on bone mineral
  • postmenopausal women. Maturitas, 28: 75– 81. metabolism in
  • Golgberg G. 2001. Plants: Diet and Health. British Publishing, pp. 138–146. Blackwell
  • Magee JP, Rowland R, 2004. Phyto- oestrogens, their mechanism of action; current evidence for e role in breast and prostate cancer. Br J Nutr., 91: 513–531.
  • Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, D’Anna R, Corrado F, Pizzoleo MA, Cincotta M, Altavilla D, Ientile R, Squadrito , 2002. Effects of genistein and hormone-replacement therapy on bone loss in early post-menopausal women: a randomized double-blind placebo-controlled study. J Bone Miner Res., 17: 1904–1912.
  • Rowland I, Faughan M, Hoey L, Wahala K, 2003. Bioavailability of phyto-oestrogens. Br J Nutr, 89 (supp 1):pp 45–58.
  • Schmitt E, Lehmann M, Metzler M, Stoper H, 2002. Hormonal and genotoxic activity of resveratrol. Toxicology Letters.136: 133-142.
  • Stopper H, Schmitt E, Kobras K, 2005. Genotoxicity of phytoestrogens. Research. 574: 139-155. Mutation
  • Ulusoylu M, 2004. İzoflavonlar. Marmara Üniversitesi Eczacılık Fakültesi Farmakognozi ABD.www.nutrisyon.com.
  • Virgilio DLA, Iwami K, Watjen W, Kohl R, Degen GH, 2004. Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells. Toxicology Letters. 151: 151-162.
  • Walter F, Ulrich S, Stein J, 2004. Molecular mechanisms of the chemopreventive effects of resveratrol and its anologs in colorectal cancer: key role of polyamines? J Nutr., 134: 3219-3222.
  • Wangen KE, Duncan AM, Kurzer MS, 2001. Soy isoflavones improve plasma lipids in normocholesterolemic hypercholesterolemic women. Am J Clin Nutr., 73: 225-31. postmenapausal
  • Wilson T, Temple NJ, 2001. Health benefits of soy isoflavones. Nutritional Health Strategies for Disease Prevention. Humana Press Inc., Totowa. pp. 75-85.

Fitoöstrojenler ve Sağlıktaki Etkileri

Yıl 2005, Cilt: 2 Sayı: 2, 91 - 95, 01.06.2005

N. İnanç Ş. Tuna

Öz

Bitki kökenli östrojenler veya östrojene benzer etkiye sahip olan bileşikler “fitoöstrojenler” olarak adlandırılır. Değişik derecelerde östrojenik etkinliğe sahip olan fitoöstrojenler, organizmada bulunan doğal östrojenlerle yarışa girer,reseptörlere bağlanarak etkinlik gösterirler. Fitoöstrojenler; izoflavonoidler, stilbenler, lignanlar ve kumestanlar olmaküzere dört alt gruba ayrılmaktadır. İzoflavonlar daha çok soya ve soya ürünlerinde ve diğer kurubaklagillerde, lignanlar;en çok keten tohumu, çavdar kepeği, kiraz, çilek gibi meyvelerde, stilbenler; yer fıstığı ve kırmızı şarapta, kumestanlarise kurubaklagillerde bulunur. Fitoöstrojenler, östrojenik ve antiöstrojenik, antioksidant, antiproliferatif veantianjiogenetik, antinflamatuar özellikler gösterebilmektedir. Östrojenik ve antiöstrojenik özellikleri ile daha çok menopoz veya osteoporoz ile ilişkili iken, antioksidant özellikleri ile kanserle ilişkili olduğu bildirilmiştir. Ancak yapılan çalışmalarda fitoöstrojenlerin etki mekanizmaları henüz tam olarak açıklanamamakta, bu bileşiklerin yaygın olarak kullanımının önerilebilmesi için daha çok çalışmaya ihtiyaç olduğu belirtilmektedir. Bu derlemede fitoöstrojenler ve sağlıktakietkileri ile ilgili makaleler özetlenmiştir

Anahtar Kelimeler

Fitoöstojenler sağlık

Kaynakça

  • Albertazzi P, Purdie WD, 2002. The nature and utility of the phytoestrogens: a review of the evidence. Maturitas, 173–185.
  • Alekel DL, Germain AS, Peterson CT, Hanson KB, Steward JW, Toda T, 2000. İsoflavone rich soy protein isolate attenuates bone loss in the lumbar spine of premenopausal women. Am J Clin Nutr., 72: 844–852.
  • Baysal A, 2002. İşlevsel besinler. Beslenme, 9. Baskı. Ankara: Hatiboğlu Yayınevi, s. 347– 354.
  • Bingham SA, Atkinson C, Liggins J, Bluck L, Coward A, 1998. Phyto-oestrogens: where are we now? Br J Nutr, 79: 393–406.
  • Boker KL, Schouw DT, Grabbee ED, Reeters HMP, 2004. Dietary phytoestrogens and breast cancer risk. Am J Clin Nutr., 79: 282– 288.
  • Büyüktuncer Z, 2000. Fitoöstrojenlerin meno- poz üzerine etkileri. IV. Uluslararası Beslen- me ve Diyetetik Kongresi Bildiriler Kitabı, 67.
  • Cornwell T, Cohick W, Raskin I, 2004. Dietary phytoestrogens and health. Phytochemistry, 65: 995–1016.
  • Fritz WA, Wang j, Lamartiniere CA, 1998. Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Am J Carcinogenesis. 2151–2158.
  • Gambacciani M, Ciaponi M, Cappagli B, Piaggesi l, Genazzani AR, 1997. Effects of combined low dose of the isoflavone derivate ipriflavone and estrogen replacement on bone mineral postmenopausal women. Maturitas, 28: 75– 81. metabolism in
  • Golgberg G. 2001. Plants: Diet and Health. British Publishing, pp. 138–146. Blackwell
  • Magee JP, Rowland R, 2004. Phyto- oestrogens, their mechanism of action; current evidence for e role in breast and prostate cancer. Br J Nutr., 91: 513–531.
  • Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, D’Anna R, Corrado F, Pizzoleo MA, Cincotta M, Altavilla D, Ientile R, Squadrito , 2002. Effects of genistein and hormone-replacement therapy on bone loss in early post-menopausal women: a randomized double-blind placebo-controlled study. J Bone Miner Res., 17: 1904–1912.
  • Rowland I, Faughan M, Hoey L, Wahala K, 2003. Bioavailability of phyto-oestrogens. Br J Nutr, 89 (supp 1):pp 45–58.
  • Schmitt E, Lehmann M, Metzler M, Stoper H, 2002. Hormonal and genotoxic activity of resveratrol. Toxicology Letters.136: 133-142.
  • Stopper H, Schmitt E, Kobras K, 2005. Genotoxicity of phytoestrogens. Research. 574: 139-155. Mutation
  • Ulusoylu M, 2004. İzoflavonlar. Marmara Üniversitesi Eczacılık Fakültesi Farmakognozi ABD.www.nutrisyon.com.
  • Virgilio DLA, Iwami K, Watjen W, Kohl R, Degen GH, 2004. Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells. Toxicology Letters. 151: 151-162.
  • Walter F, Ulrich S, Stein J, 2004. Molecular mechanisms of the chemopreventive effects of resveratrol and its anologs in colorectal cancer: key role of polyamines? J Nutr., 134: 3219-3222.
  • Wangen KE, Duncan AM, Kurzer MS, 2001. Soy isoflavones improve plasma lipids in normocholesterolemic hypercholesterolemic women. Am J Clin Nutr., 73: 225-31. postmenapausal
  • Wilson T, Temple NJ, 2001. Health benefits of soy isoflavones. Nutritional Health Strategies for Disease Prevention. Humana Press Inc., Totowa. pp. 75-85.
  • ipriflavone and estrogen replacement on bone mineral
  • postmenopausal women. Maturitas, 28: 75– 81. metabolism in
  • Golgberg G. 2001. Plants: Diet and Health. British Publishing, pp. 138–146. Blackwell
  • Magee JP, Rowland R, 2004. Phyto- oestrogens, their mechanism of action; current evidence for e role in breast and prostate cancer. Br J Nutr., 91: 513–531.
  • Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, D’Anna R, Corrado F, Pizzoleo MA, Cincotta M, Altavilla D, Ientile R, Squadrito , 2002. Effects of genistein and hormone-replacement therapy on bone loss in early post-menopausal women: a randomized double-blind placebo-controlled study. J Bone Miner Res., 17: 1904–1912.
  • Rowland I, Faughan M, Hoey L, Wahala K, 2003. Bioavailability of phyto-oestrogens. Br J Nutr, 89 (supp 1):pp 45–58.
  • Schmitt E, Lehmann M, Metzler M, Stoper H, 2002. Hormonal and genotoxic activity of resveratrol. Toxicology Letters.136: 133-142.
  • Stopper H, Schmitt E, Kobras K, 2005. Genotoxicity of phytoestrogens. Research. 574: 139-155. Mutation
  • Ulusoylu M, 2004. İzoflavonlar. Marmara Üniversitesi Eczacılık Fakültesi Farmakognozi ABD.www.nutrisyon.com.
  • Virgilio DLA, Iwami K, Watjen W, Kohl R, Degen GH, 2004. Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells. Toxicology Letters. 151: 151-162.
  • Walter F, Ulrich S, Stein J, 2004. Molecular mechanisms of the chemopreventive effects of resveratrol and its anologs in colorectal cancer: key role of polyamines? J Nutr., 134: 3219-3222.
  • Wangen KE, Duncan AM, Kurzer MS, 2001. Soy isoflavones improve plasma lipids in normocholesterolemic hypercholesterolemic women. Am J Clin Nutr., 73: 225-31. postmenapausal
  • Wilson T, Temple NJ, 2001. Health benefits of soy isoflavones. Nutritional Health Strategies for Disease Prevention. Humana Press Inc., Totowa. pp. 75-85.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

N. İnanç Bu kişi benim

Ş. Tuna Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2005
Gönderilme Tarihi 24 Haziran 2014
Yayımlandığı Sayı Yıl 2005 Cilt: 2 Sayı: 2

Kaynak Göster

APA İnanç, N., & Tuna, Ş. (2005). Fitoöstrojenler ve Sağlıktaki Etkileri. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 2(2), 91-95.
AMA İnanç N, Tuna Ş. Fitoöstrojenler ve Sağlıktaki Etkileri. Erciyes Üniv Vet Fak Derg. Haziran 2005;2(2):91-95.
Chicago İnanç, N., ve Ş. Tuna. “Fitoöstrojenler Ve Sağlıktaki Etkileri”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 2, sy. 2 (Haziran 2005): 91-95.
EndNote İnanç N, Tuna Ş (01 Haziran 2005) Fitoöstrojenler ve Sağlıktaki Etkileri. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 2 2 91–95.
IEEE N. İnanç ve Ş. Tuna, “Fitoöstrojenler ve Sağlıktaki Etkileri”, Erciyes Üniv Vet Fak Derg, c. 2, sy. 2, ss. 91–95, 2005.
ISNAD İnanç, N. - Tuna, Ş. “Fitoöstrojenler Ve Sağlıktaki Etkileri”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 2/2 (Haziran 2005), 91-95.
JAMA İnanç N, Tuna Ş. Fitoöstrojenler ve Sağlıktaki Etkileri. Erciyes Üniv Vet Fak Derg. 2005;2:91–95.
MLA İnanç, N. ve Ş. Tuna. “Fitoöstrojenler Ve Sağlıktaki Etkileri”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, c. 2, sy. 2, 2005, ss. 91-95.
Vancouver İnanç N, Tuna Ş. Fitoöstrojenler ve Sağlıktaki Etkileri. Erciyes Üniv Vet Fak Derg. 2005;2(2):91-5.
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