Effects of Aging on Plasma Oxidant -Antioxidant Values in Horses

Yıl 2006, Cilt: 3 Sayı: 2, 73 - 77, 01.06.2006

N. Aydilek H. Şimşek

Öz

-

Anahtar Kelimeler

Yaşlanma, Kısrak, Oksidan, Antioksidan

Yaşlanmanın Kısraklarda Plazma Oksidan ve Antioksidan Parametreler Üzerine Etkisi

Öz

Yaşlanma, her organizmanın yaşamı için kaçınılmaz bir süreçtir. Yaşlanmayla ilgili oldukça geniş kabul görenteorilerden biri de serbest radikal teorisidir. Bu çalışmada oksidatif stresin bir göstergesi olan malondialdehit (MDA) vebazı antioksidan parametreler ölçülerek yaşlanmanın kısrak plazmasındaki oksidan ve antioksidan değerleri üzerineetkisi araştırıldı. Çalışmada 15 genç (5-10 yaş) ve 15 yaşlı (15-20 yaş) Arap kısrağı kullanıldı. Yaşlı atlardaki kısraklarda plazma MDA seviyesi gençlere göre önemli derecede yüksek bulunurken (P

Anahtar Kelimeler

Yaşlanma, Kısrak, Oksidan, Antioksidan

Kaynakça

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• Hollander D, Dadufalza V, 1989. Lymphatic and portal absorption of vitamin E in aging rats. Dig Dis Sci., 34: 768-72.
• Hollander D, Dadufalza V, 1990. Influence of aging on vitamin A transport into the lymphatic circulation. Exp Gerontol., 25: 61-5.
• İnal ME, Kanbak G, Sunal E, 2001. Antioxi- dant enzyme activities and malondialdehyde levels related to aging. Clin Chim Acta., 305: 75-80.
• Kim JW, No JK, Ikeno Y, Yu BP, Choi JS, Yokozawa T, Chung HY, 2002. Age-related changes in redox status of rat serum. Arch Gerontol Geriat., 34: 9-17.
• Lawrence RA, Burk RF, 1976. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun., 71: 952-958.
• Maher P, 2005. The effects of stres and aging on glutathione metabolism. Aging Res Rev., 4: 288-314.
• Matkovics B, Szabo L, Varga I, 1988. Determination of enzyme activities in lipid peroxidation and glutathione pathways (in Hungarian). Lab Diag., 15: 248-250.
• Mecocci P, Polidori MC, Troiano L, Cherubini A, Cecchetti R, Pini G, Straatman M, Monti D, Stahl W, Sies H, Franceschi C, Senin U, 2000. Plasma antioxidants and lon- gevity: A study on healthy centenarians. Free Radic Biol Med., 28: 1243-1248.
• Pansarasa O, Bertorelli L, Vecchiet J, Marzatico Felzani dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle. Free Radic Biol Med., 27: 617-622. F, 1999. Age
• Placer ZA, Cushmann LL, Johnson BC, 1966. Estimation of products of lipid peroxida- tion (as malondialdehyde) in biochemical sys- tems. Anal Biochem., 16: 359-364. 21. Rodriguez MMA, Ruiz TA, 1992. Homeostasis between lipid peroxidation and antioxidant enzyme activities in healthy human aging. Mech Ageing Dev., 66: 213- 222.
• Samiec PS, Drews-Botsch C, Flagg EW, Kurtz JC, Sternberg P, Reed RL, Jones DP, 1998. Glutathione in human plasma: Decline in association with aging, age-related macular degeneration, and diabetes. Free Radic Biol Med., 24: 699-704.
• Sawada M, Carlson JC, 1987. Changes in superoxide formation in the brain, heart and liver during the lifetime of the rat. Mech Ageing Dev., 41: 125-37. and lipid peroxide
• Sedlak J, Lindsay RHC, 1968. Estimation of total, protein bound and non-protein sulfhydryl groups in tissue with Ellmann’s reagent. Anal Biochem., 25:192-205.
• Sies H, Stahl W, Sundquist AR, 1992. Antioxidant functions of vitamins: Vitamins E and C, beta carotene and other caratenoids. Ann NY Acad Sci., 669: 7-20.
• Sinitsyna O, Krysanova Z, Ishchenko A, Dikalova AE, Stolyarov S, Kolosova N, Vasunina E, Nevinsky G, associated changes in oxidative damage and the activity of antioxidant enzymes in rats with inherited overgeneration of free radicals. J Cell Mol Med., 10: 206-215. 2006. Age
• Sohal RS, Agarwal S, Sohal BH, 1995. Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus). Mech Ageing Dev., 81: 15-25.
• Stio M, Iantomasi T, Favilli F, Marraccini P, Lunghi B, Vincenzini MT, Treves C, 1994. Glutathione metabolism in heart and liver of the aging rat. Biochem Cell Biol., 72: 58-61.
• Suzuki J, Katoh N, 1990. A simple and cheap method for measuring vitamin A in cattle using only a spectrophotometer. Jpn J Vet Sci., 52: 1282-1284.
• Turrens JF, Boveris A, 1980. Generation of superoxide anion by the NADH dehydro- genase of bovine heart miochondria. Biochem J., 191: 421-427.
• Wang X, Quinn PJ, 1999. Vitamin E and its function in membranes. Prog Lipid Res., 38: 309-336
• Yargıçoğlu P, Gümüşlü S, Ağar A, Korgun DK, Kücükatay V, 2001. Effect of sulfur dioxide inhalation on erythrocyte antioxidant status, food intake, and lipid peroxidation during aging. Arch Environ Healt., 56: 53-57.