AN IMPORTANT FIVE-MEMBERED HETEROAROMATIC COMPOUND: PYRROLE

Yıl 2006, Cilt: 22 Sayı: 1, 121 - 141, 01.02.2006

Bülent Dede

Öz

The synthesis of pyrroles is an important area of heterocyclic chemistry due primarily to the fact that many pyrroles are subunits of natural products. Several alkylpyrrole derivatives have also been shown to possess remarkable biological activity. Although there are a quite number of methods available for the synthesis of pyrroles, most of them involve multistep synthetic operations which lower the overall yield. Thus, development of new synthetic methods still remains an attractive goal. In this review, a short information is given about pyrrole and then it is investigated studies about synthesis of pyrroles those is made for last twenty years.

Anahtar Kelimeler

Pyrrole, Pyrrole synthesis, Five-membered ring

ÖNEMLİ BİR BEŞ-ÜYELİ HETEROAROMATİK BİLEŞİK: PİROL

Öz

Piroller, çoğu doğal ürünlerin özünü oluşturduğundan dolayı heterosiklik kimyada pirollerin sentezinin önemli bir yeri vardır. Çeşitli alkilpirol türevlerinin çok iyi bir derecede biyolojik aktiviteye sahip olduğu görülmüştür. Bundan dolayı pirollerin sentezi amacıyla kullanışlı birçok metot olmasına rağmen bu metotların birçoğu çok fazla sentetik basamak içerdiklerinden dolayı sonuçta oluşan pirol türevlerinin verimleri yeteri kadar yüksek olmamaktadır. Bundan dolayı pirol türevlerinin sentezi için yapılan çalışmalar halen yapılmaya devam etmektedir. Bu makalede pirol hakkında kısa bir bilgi verildikten sonra pirolün sentezi için son yirmi yıl içerisinde yapılan çalışmalar incelenmiştir.

Anahtar Kelimeler

Pirol, Pirol sentezi, Beş-üyeli halka

Kaynakça

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