Yeni Tiyoüre Türevi Bileşek Sentezi, Karakterizasyonu, Termal Özellikleri ve Antibakteriyel Etkinliğinin Araştırılması

Yıl 2025, Cilt: 41 Sayı: 1, 43 - 50, 30.04.2025

Emine Kutlu

Öz

Tiyoüre türevi olan N-(2,4-dimetilpiridin-karbamotiyoil)-3-nitrobenzamid (C15H15N3O3S) sentezlendi ve yapısal karakterizasyonu FT-IR, 1H-NMR ve UV-vis teknikleri kullanılarak gerçekleştirildi. N-(2,4-dimetilpiridin-karbamotiyoil)-3-nitrobenzamid’in termal özellikleri Termogravimetri (TG)/Diferansiyel Termal Analiz (DTA)/Diferansiyel Termogravimetri (DTG) kombine sistemi ile analiz edildi. TG ve DTG eğrilerinden 112-195 ºC aralığında %1,80 kütle kaybı ile ve 195-295 ºC aralığında %97,76 kütle kaybı ile iki basamaklı bozunmanın gerçekleştiği anlaşılmaktadır. Sentezlenen bileşiğin Staphylococcus aureus ATCC 25923 (S. aureus), Escherichia coli ATCC 35150 (E. coli), Salmonella enterica ATCC 700408 (S. Enterica), Listeria monocytogenes RSKK 472 (L. monocytogenes) standart suşlarına karşı antibakteriyel etkinliği incelendi. Bileşiğin S. aureus, E. coli, ve L. monocytogenes suşları üzerinde elde edilen MİK Değeri 50 mg/mL olarak, S. enterica suşları üzerinde ise 25 mg/mL olarak hesaplandı.

Anahtar Kelimeler

Aroiltiyoüre, 3-nitrobenzamid, 2,4-dimetilpridin, Antibakteriyel aktivite.

Destekleyen Kurum

Burdur Mehmet Akif Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Proje Numarası

Proje, Burdur Mehmet Akif Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından 0282-NAP-16 proje numarası ile desteklenmiştir.

Teşekkür

Çalışmada yer alan antibakteriyel uygulamalar için Burdur Mehmet Akif Ersoy Üniversitesi Bilimsel ve Teknoloji Uygulama ve Araştırma Merkezine, Öğr. Gör. Orhan YAVUZ’a ve Prof. Dr. Fatih Mehmet Emen’e vermiş oldukları destek ve katkılardan dolayı teşekkür ederim.

Kaynakça

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