MikroRNA’ların Atletik Performansa Etkisi

Yıl 2020, Cilt: 5 Sayı: 1, 103 - 109, 20.06.2020

İrem Altuntaş Tolga Polat Korkut Ulucan

Öz

Ribonükleik asit (RNA) yapı taşı ribonükleotid olan ve translasyon sürecinden genlerin düzenlenmesine
kadar geniş rol aralığı olan moleküldür. Farklı metabolik süreçlerde farklı RNA türleri görev alır. MikroRNA
(miRNA)’lar yaklaşık 22 nükleotit uzunluğunda, protein kodlamayan ve gen regülasyonu sırasında
transkripsiyon ve translasyonu regüle eden RNA molekülleridir. Bu yüzden dolaşımda bulunan miRNA’lar
farklı biyolojik süreçlere etki edebilir. Yapılan çalışmalar ile miRNA’nın egzersiz sırasında etkili olduğu
gözlemlenmiştir. Bu sebeple egzersiz başta olmak üzere insan fizyolojisi ve hastalık araştırmalarında
biyobelirteç olarak kullanılma potansiyeline sahiptirler. Yapılan çalışmalar miRNA seviyesinin egzersize
bağlı olarak değiştiğini göstermiştir. Ek olarakta farklı egzersiz tiplerinin miRNA seviyelerine etki
ettiği gözlemlenmiştir. Bu derlemede yapılan bazı miRNA ve egzersiz hakkındaki çalışmalar ve bu
çalışmaların sonuçlarının özeti sunulmaktadır. Elde edilen bulgular düzenli egzersizlerin farklı miRNA
çeşitlerinin seviyesini arttırabileceğini, azaltabileceğini veya önemli olmayan seviyede değiştirebileceğini
göstermektedir.

Anahtar Kelimeler

miRNA, ci-miRNA, atletik performans, egzersiz.

Effect of MicroRNAs on Athletic Performance

Öz

Ribonucleic acid (RNA) is the molecule whose building block is ribonucleotide and has a wide role range
from translation process to regulation of genes. Different types of RNA are involved in different metabolic
processes. miRNAs are special RNA molecules of about 22 nucleotides in length, which do not encode
protein and regulate transcription and translation during gene regulation. Therefore, circulating miRNAs
can affect different biological processes. Studies have shown that microRNA (miRNA) is effective during
exercise. For this reason, they have the potential to be used as biomarkers in human physiology and disease
research, especially in exercise. Studies have shown that the level of miRNA varies depending on exercise.
In addition, it has been observed that different exercise types affect miRNA levels. In this review, some
studies on miRNA and exercise and the results of these studies are presented. The findings show that
regular exercises can increase, decrease, or alter non-significant levels of different types of miRNA.

Anahtar Kelimeler

miRNA, ci-miRNA, athletic performance, exercise.

Kaynakça

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