Benzimidazole-Platinum Complex and Its Cytotoxic activity on U87 Cell Lines

Yıl 2024, , 230 - 240, 28.03.2024

Aydan Arı , Salih Günnaz , Sevil İrişli

https://doi.org/10.18185/erzifbed.1407972

Öz

Çalışmanın amacı, güçlü sitotoksik aktiviteye ve düşük yan etkilere sahip olabilen yeni bir benzimidazol-platin(II) kompleksinin sentezi, karakterizasyonu ve sitotoksik aktivitelerinin değerlendirilmesidir. Bir benzimidazol ligandı, 2-(3-fenoksifenil)-1-fenil-1H-benzimidazol (L) ve bunun yeni platin kompleksi (Pt-L), sentezlenmiş yapıları farklı spektroskopik yöntemlerle karakterize edilmiştir. Çalışmada, sentezlenen kompleksin öncelikle U87 kanser hattındaki aktivitesi incelenmiş, daha sonra sağlıklı Vero hatları üzerinde çalışılmıştır.

Anahtar Kelimeler

Benzimidazole, Benzimidazole- Platinum complexes, glioblastoma, cytotoxic activity

Etik Beyan

There are no ethical issues regarding the publication of this study

Destekleyen Kurum

Ege University Scientific Research Project (No: FYL -2019 21012)

Proje Numarası

FYL -2019 21012

Teşekkür

We also give thanks to MATAL Center, Ege University, for cytotoxicity activities.

Kaynakça

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