Analyzing Lead Concentrations in Pregnant Women Following Topical Application of Eau de Goulard (2% lead subacetate) via ICP-MS

Öz

Öz Kurşun bileşiklerinin sitotoksisite ve genotoksisiteye neden olduğu bilinmektedir. Kurşunun cilt tarafından emilmesi, bu metalin vücuda girişinin önemli bir yoludur. Eau de Goulard (EDG), kateter çevresinde ödem ve flebit oluşumunu önlemek amacıyla sıklıkla topikal olarak kullanılır. EDG'de kurşun subasetat bulunması, potansiyel kurşun maruziyetine ilişkin endişelere neden olmaktadır. Çalışmada, 10 hamile kadının tam kanındaki kurşun konsantrasyonları, EDG'nin topikal uygulamasından önce ve uygulamadan 120 dakika sonra indüktif eşleşmiş plazma kütle spektrometresi ile ölçüldü. Tam kan örneklerinin analizinde ortalama kurşun konsantrasyonu 0. dakikada 12.763 ppb, 120. dakikada ise 15.823 ppb olarak belirlendi. Paired-Samples t-testi kullanılarak yapılan istatistiksel analiz, tam kandaki kurşun seviyeleri ile topikal EDG uygulamasından sonra geçen süre arasında anlamlı bir korelasyon olduğunu gösterdi (R:0,981, p:0,000). Çalışma, kısa süreli uygulamanın bile hamile kadınların tam kanındaki kurşun konsantrasyonunu önemli ölçüde artırdığını gösterdi (p<0.05). Bu uygulama kurşuna maruz kalma nedeniyle potansiyel sağlık riskleri taşır. Çalışma, topikal EDG uygulamasının hem anne hem de fetus sağlığını tehdit ettiğini, flebit ve ödemin önlenmesi için daha güvenli tıbbi uygulamalara ihtiyaç duyulduğunu ortaya koydu. Bu uygulamaya alternatif olarak EDG, hem kurşun maruziyetini sınırlamak hem de kurşunun kan dolaşımına girmesini önlemek amacıyla daha kısa süre ve daha uzun aralıklarla topikal olarak kullanılabilir veya daha düşük kurşun konsantrasyonlu EDG solüsyonlarının kullanılması alternatif bir yaklaşım olarak görünmektedir.

Anahtar Kelimeler

• ICP-MS
• Lead
• Eau de Goulard
• Trace elements
• Validation

Etik Beyan

Written informed consent was obtained from each patient. The study was carried out in accordance with the Declaration of Helsinki and approved by the Atatürk University Clinical Research Ethics Committee on 07.11.2019 (Permission Number: B.30.2.ATA.0.01.00, Decision Number: 65/482).

Teşekkür

The authors are grateful to Atatürk University for support of this study.

Kaynakça

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