Synthesis and antitubercular activities of acetamide-substituted benzazole derivatives

Yıl 2024, , 474 - 487, 31.08.2024

Şule Gürsoy , Elif Şevval Öztürk , Bayan Zoatier , Mahmut Ülger , Öztekin Algül

https://doi.org/10.18185/erzifbed.1480781

Öz

Multidrug-resistant Mycobacterium tuberculosis strains' increasing emergence and rapid spread necessitate the urgent development of innovative antimycobacterial agents. In pursuit of novel agents, a series of N-(benzazole-2-ylmethyl)-2-substituted phenylacetamide or N-(benzazole-2-ylmethyl)-2-(thiophen-2-yl)acetamide compounds (6-11) were synthesized. Their efficacy against multidrug-resistant Mycobacterium tuberculosis was assessed. Compounds exhibited potent antimycobacterial activity with minimum inhibitory concentrations (MIC) ranging from 1.05 to 4.10 µM and demonstrated low cytotoxicity towards fibroblast cell line (L929). ADMET predictions suggested that these synthesized compounds possess drug-like properties. Our findings offer a promising starting point for designing more selective and potent antimycobacterial agents.

Anahtar Kelimeler

Benzazole, synthesis, Mycobacterium tuberculosis, MIC, antitubercular activity

Etik Beyan

Gerekli değildir

Destekleyen Kurum

Research Fund of Erzincan Binali Yıldırım University

Proje Numarası

TYL-2023-944

Teşekkür

This study is funded by the Research Fund of Erzincan Binali Yıldırım University, Turkey (Project number: TYL-2023-944). We would like to thank Erzincan Binali Yıldırım University for its support.

Kaynakça

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