The Effects of Garlic Extracts on Prostate Cancer

Öz

In the current study, garlic samples obtained from various provinces of Turkey, including Kastamonu, Balikesir, Edirne, and Aksaray, were analyzed for their chemical composition and biological activity. The organosulfur content of the prepared extracts was assessed using GC-MS. A total of seven compounds were identified across all samples, with 3-Vinyl-4H-1,2-dithiin and 2-Vinyl-4H-1,3-dithiin recognised as the predominant compounds. Additionally, the effects of these extracts on benign prostatic hyperplasia (BPH), as well as on the LNCaP, DU145, and PC3 cell lines, were evaluated using MTT assays. Cytotoxic activity was detected in all samples examined. The most pronounced activity was recorded against the LNCaP cell lines, exhibiting varying IC50 values ranging from 23.91 to 48.84 µg/ml.

Anahtar Kelimeler

• Garlic
• Organosulfur compounds
• Prostate cancer

Destekleyen Kurum

Ege University Scientific Research Projects Coordination Unit

Proje Numarası

29638

Sarımsak Ekstrelerinin Prostat Kanseri Üzerindeki Etkileri

Öz

Mevcut çalışmada, Kastamonu, Balıkesir, Edirne ve Aksaray olmak üzere Türkiye'nin çeşitli illerinden temin edilen sarımsak örnekleri kimyasal bileşimleri ve biyolojik aktiviteleri açısından analiz edildi. Hazırlanan ekstraktların organosülfür içeriği GC-MS kullanılarak değerlendirildi. Tüm örneklerde toplam yedi bileşik tanımlandı ve 3-Vinil-4H-1,2-ditiin ve 2-Vinil-4H-1,3-ditiin baskın bileşikler olarak tanındı. Ek olarak, bu ekstraktların iyi huylu prostat hiperplazisi (BPH) üzerindeki etkileri ve LNCaP, DU145 ve PC3 hücre hatları üzerindeki etkileri MTT analizleri kullanılarak değerlendirildi. İncelenen tüm örneklerde sitotoksik aktivite tespit edildi. En belirgin aktivite, 23,91 ila 48,84 µg/ml arasında değişen IC50 değerleri gösteren LNCaP hücre hatlarına karşı kaydedildi

Anahtar Kelimeler

• Sarımsak
• Organosülfür bileşikleri
• Prostat kanseri

Proje Numarası

29638

Kaynakça

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