Synthesis, Characterization and Antimicrobial Activity of Novel Etoksibenzilidenamino Eerived 1,2,4-triazoles

Öz

The benzaldehyde and their derivatives have a good antimicrobial properties. Our research aim is to improve the antimicrobial effect, different derived from 3-Alkil/aril-4 triozole and metoksibenzoksi. The synthesized triazoles were characterized by spectroscopic techniques, such as, 1H NMR, 13C NMR, UV absorption spectra, and mass spectra (MS). We were mesured their antibacterial activities in vitro against Bacillius subtilis, Yersinia enterocolitca, Bacillus cereus, Staphlacoccus aureus, Esherichia coli, Pasterulla multicida, Klepsiella pnemonias. The synthesis of a series of etoksibenzilidenamino derived 1,2,4-triazoles has been realized with good yields using the CuAAC of a variety of alkynyl heterocycles, alkynyl carbohydrates or alkynes. The structures of the obtained compounds were confirmed by NMR spectroscopy (1H and 13C) and mass spectrometry. Overall, the molecules are not showed very antibacterial activity, but our antibiotic showed that important antibacterial activity. 

Anahtar Kelimeler

• 3-Alkil/aril-1
• 2
• 4-triazole
• benzaldehyde
• Antibacterial activity
• Disc diffusion method

1,2,4-triyazolden Kaynaklanan Yeni Kuşak Etoksibenzilidenaminonun Sentez, Karekterizasyon ve Antimikrobiyel Akvitesi

Öz

Benzaldehit ve türevleri iyi bir antimikrobiyal özelliklere sahiptir. Bu Çalışmanın amacı, 3-Alkil / aril-4 triozole ve metoksibenzoksi'den elde edilen farklı antimikrobiyal etkinin geliştirilmesidir. Sentezlenen triazoller, 1H NMR, 13C NMR, UV absorpsiyon spektrumu ve kütle spektrumu (MS) gibi spektroskopik teknikler ile karakterize edildi. Antibakteriyel faaliyetlerini Bacillius subtilis, Yersinia enterocolitca, Bacillus cereus, Staphlacoccus aureus, Esherichia coli, Pasterulla multicida, Klepsiella pneumoniae'lere karşı in vitro olarak uygulandı.. Etoksibenzilidenamino türevi 1,2,4-triazollerin bir sentezi, çeşitli alkinil heterosikllerin, alkinil karbonhidratların veya alkinlerin CuAAC kullanılarak iyi verim ile gerçekleştirildi. Elde edilen bileşiklerin yapıları NMR spektroskopisi ( 1H ve 13C) ve kütle spektrometrisi ile teyit edildi. Genel olarak, moleküller çok antibakteriyel aktivite göstermedi; ancak antibiyotik önemli antibakteriyel aktivite gösterdi. 

Anahtar Kelimeler

• 3-Alkil/aril-1
• 2
• 4-triazole
• benzaldehyde
• Antibacterial etki
• Disc difuzyon yöntemi

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