An Efficient Synthesis of Novel Type Chalcones Containing 8-hydroxyquinoline Under Green Conditions

Öz

In this study, new type of chalcones containing 8-hydroxyquinoline as an alternative to natural and synthetic chalcones have synthesized for the first time using microwave irradiation with environmentally benign approach. Firstly, (E)-1-(4-((8-hydroxyquinolin-5-yl)diazenyl)phenyl)ethanone (3) were synthesized by diazotization of p-aminoacetophenone. Secondly, most important step of synthesis included the Claisen-Schmidt condensation of chalcones using the microwave method. The structures of all compounds were characterized by means of FT-IR, NMR and elemental analysis.

Anahtar Kelimeler

• Azo coupling,Chalcone,Diazotization,8-Hydroxyquinoline

An Efficient Synthesis of Novel Type Chalcones Containing 8-hydroxyquinoline Under Green Conditions

Öz

Bu çalışmada, çevreci bir yaklaşımla mikrodalga ışıması kullanılarak doğal ve sentetik kalkonlara alternatif olarak 8-hidroksikinolin içeren yeni tip kalkonlar ilk kez sentezlendi. İlk olarak, (E)-1-(4-((8-hidroksikinolin-5-yl)diazenil)fenil)ethanon (3) p-aminoasetofenonun diazotizasyonu tarafından sentezlendi. İkincil olarak sentezin en önemli adımını, mikrodalga yöntemi kullanılarak kalkonların Claisen-Schmidt kondenzasyonunu içermektedir. Tüm bileşiklerin yapıları FT-IR, NMR ve elemental analiz yöntemleriyle karakterize edildi.

Anahtar Kelimeler

• Azo kenetlenme,Diazotizasyon,Kalkon,8-Hidroksikinolin

Kaynakça

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