Research to Short- and Long Term Memory Effects of Three Nerve Cell Motif Based Neuronal Networks

Öz

There are important biological studies on memory and learning. Examination of brain cells in solution and living tissue media and also image studies with electron microscope revealed important findings. The obtained biological data showed that many nerve cells in the brain formed complex connections. In this great biological neural network structure; repeated and motif-named sections were observed. These motifs are believed to be the building blocks of biological neural networks and play important functional roles in the network. It is thought that in order to understand the memory behavior of this nerve network in the brain, it is necessary to know the behavior of the motifs. With the help of these experimental data, the motifs are modeled by computational methods. From studies done on models; biological memory behaviors of motifs are examined. In this study, short- and long-term memory functions of all three-cell neural network motifs were examined. Motives were created using graph theory. The nerve cells forming the motifs were modeled in the soma part of the cell using a Hodkgin-Huxley model as a single chamber. In addition, the intercellular connection was modeled as a chemical synapse. All three-celled motif models were developed in the Matlab software environment. The results of the studies on the models showed that the three-cell motifs showed short-term and long-term memory behavior. At the end of the study, short-term and long-term memory behavior of three-cell motifs were determined.

 

Tüm Üç Hücreli Biyolojik Sinir Ağı Motiflerinin Kısa- ve Uzun Dönem Bellek Davranışının İncelenmesi

Öz

Bellek ve öğrenme ile ilgili önemli biyolojik çalışmalar yapılmaktadır. Beyin hücrelerinin, çözelti ve canlı doku ortamlarında incelenmesi ve ayrıca elektron mikroskopla görüntü çalışmaları, önemli bulgular ortaya koymuştur.  Elde edilen biyolojik veriler, beyinde çok sayıda sinir hücresinin, karmaşık bağlantılar oluşturduğunu göstermiştir. Bu büyük biyolojik sinir ağı yapısında; tekrarlanan ve motif olarak isimlendirilen bölümler gözlenmiştir. Bu motiflerin, biyolojik sinir ağlarının temel yapı blokları olduğuna ve ağda önemli fonksiyonel roller oynadığına inanılmaktadır. Beyindeki bu sinir ağının bellek davranışını anlamak için, motiflerin davranışlarını bilmek gerektiği düşünülmektedir. Bu deneysel veriler yardımıyla, motifler hesapsal yöntemlerle modellenmiştir. Modeller üzerinde yapılan çalışmalardan; motiflerin biyolojik bellek davranışları incelenmektedir. Bu çalışmada tüm üç hücreli sinir ağı motiflerinin kısa- ve uzun dönem bellek fonksiyonları incelendi. Motifler, graph teorisi kullanılarak oluşturuldu. Motifleri oluşturan sinir hücreleri, Hodkgin-Huxley model kullanılarak, hücrenin soma kısmında, tek bölme şeklinde modellendi. Ayrıca hücreler arası bağlantı, kimyasal sinaps şeklinde modellendi. Oluşturulan tüm üç hücreli motif modelleri, Matlab yazılım ortamında geliştirildi. Modeller üzerinde yapılan çalışmalarda elde edilen sonuçlardan, üç hücreli motiflerin kısa –ve uzun dönem bellek davranışı gösterme durumları belirlendi. Çalışmanın sonunda, üç hücreli motiflerden kısa –ve uzun dönem bellek davranışı sergileyenler tespit edildi.

Anahtar Kelimeler

• Biyolojik ağ,motif,hodkgin-huxley hücre modeli,kısa-dönem bellek,uzun-dönem bellek

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