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New Generation Biomaterials Used in Delivery of Therapeutic Molecules

Yıl 2018, Cilt: 11 Sayı: 3, 524 - 542, 30.12.2018
https://doi.org/10.18185/erzifbed.339405

Öz

Recently, with the discovery
of the RNA interference mechanism, transfection of various small nucleic acid
fragments (miRNA, siRNA, shRNA and plasmid DNA etc.) has been gradually gaining
importance and it is nowadays being used for silencing of the specific gene
regions causing many diseases. The barriers in delivery of therapeutic nucleic
acids, drug, DNA or protein vaccines, which are aimed to used in treatment of
many diseases, into tissue and cells restrict the developments in this field.
Consequently, polymer, inorganic and lipid-based biomaterials or composites
synthetized from aforementioned biomaterials are tailored through various
modification for the delivery of nucleic acids, drugs and DNA/protein vaccines.
Also, nanoparticles are able to be more functionalized by optimizing or
modifying them to reduce the toxic effects and to target cell being
transfected. In the development of new generation therapeutics; i) new nucleic acid types, ii) surpassing biological barriers
restricting transfection efficiency, iii)
synthesis of more functional nano-biomaterials are being intensively studied in vitro/in vivo conditions and promising developments are being
experienced. In this review article, different biomaterials are classified
depending on their structures, discussed in detail and reference studies
regarding therapeutic applications of these biomaterials are presented in the
light of recent developments in the literature.

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Terapötik Moleküllerin Aktarımında Kullanılan Yeni Nesil Biyomalzemeler

Yıl 2018, Cilt: 11 Sayı: 3, 524 - 542, 30.12.2018
https://doi.org/10.18185/erzifbed.339405

Öz



Son yıllarda, RNA interferans mekanizmasının
keşfedilmesiyle birlikte çeşitli ufak nükleik asit parçacıklarının (miRNA,
siRNA, shRNA ve plazmid DNA vb.) transfeksiyonu giderek önem kazanmakta ve
günümüzde birçok hastalığa sebep olan spesifik gen bölgelerinin susturulması
için kullanılmaktadır. Birçok hastalığın tedavisinde kullanılması hedeflenen
terapötik nükleik asitlerin, ilaç veya aşıların doku ve hücrelere aktarılmasındaki
engeller bu alandaki gelişmeleri sınırlamaktadır. Bu doğrultuda, polimer,
inorganik ve lipit bazlı çeşitli biyomalzemeler veya bu biyomalzemelerden
oluşan kompozitler çeşitli modifikasyonlara uğratılarak terapötik nükleik
asit, ilaç veya DNA/protein aşısı aktarımı için uygun hale getirilmektedir.
Aynı zamanda, toksik etkiyi azaltmak ve aktarımın yapılacağı hücreyi
hedeflemek için çeşitli optimizasyon ve modifikasyonlar yapılarak
nanoparçacıklar daha fonksiyonel hale getirilebilmektedirler. Yeni nesil
terapötiklerin geliştirilmesinde; i)
yeni nükleik asit tipleri, ii)
transfeksiyon verimini sınırlayan biyolojik bariyerlerin aşılması, iii) daha fonksiyonel
nano-biyomalzemelerin sentezi in vitro/in vivo ortamlarda yoğun bir şekilde
araştırılmakta ve umut vaat eden gelişmeler yaşanmaktadır. Bu derleme
makalesinde, literatürdeki güncel gelişmeler göz önünde tutularak farklı
biyomalzemeler yapılarına göre sınıflandırılmış, ayrıntılı bir şekilde
incelenmiş ve bu biyomalzemelerin terapötik uygulamalarda kullanımıyla ilgili
örnek çalışmalara yer verilmiştir.


Kaynakça

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  • McCallion, C., Burthem, J., Rees-Unwin, K., Golovanov, A., ve Pluen, A. 2016. Graphene in therapeutics delivery: Problems, solutions and future opportunities. European Journal of Pharmaceutics and Biopharmaceutics, 104, 235–250.
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  • Nia, A. H., Eshghi, H., Abnous, K., ve Ramezani, M. 2017. The intracellular delivery of plasmid DNA using cationic reducible carbon nanotube — Disulfide conjugates of polyethylenimine. European Journal of Pharmaceutical Sciences, 100, 176–186.
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  • Ochrimenko, S., Vollrath, A., Tauhardt, L., Kempe, K., Schubert, S., Schubert, U. S., ve Fischer, D. 2014. Dextran-graft-linear poly(ethylene imine)s for gene delivery: Importance of the linking strategy. Carbohydrate Polymers, 113, 597–606.
  • Ohta, T., Hashida, Y., Yamashita, F., ve Hashida, M. 2016. Development of Novel Drug and Gene Delivery Carriers Composed of Single-Walled Carbon Nanotubes and Designed Peptides With PEGylation. Journal of Pharmaceutical Sciences, 105(9), 2815–2824.
  • Oliveira, A. V., Marcelo, A., Rosa da Costa, A. M., ve Silva, G. A. 2016. Evaluation of cystamine-modified hyaluronic acid/chitosan polyplex as retinal gene vector. Materials Science and Engineering: C, 58, 264–272.
  • Ozpolat, B., Sood, A. K., ve Lopez-Berestein, G. 2014. Liposomal siRNA nanocarriers for cancer therapy. Advanced Drug Delivery Reviews, 66, 110–116.
  • Pandey, A. P., ve Sawant, K. K. 2016. Polyethylenimine: A versatile, multifunctional non-viral vector for nucleic acid delivery. Materials Science and Engineering: C, 68, 904–918.
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  • Perche, F., Yi, Y., Hespel, L., Mi, P., Dirisala, A., Cabral, H., Miyata, K., Kataoka, K. 2016. Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity. Biomaterials, 90, 62–71.
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  • Sharma, S., Verma, A., Teja, B. V., Pandey, G., Mittapelly, N., Trivedi, R., ve Mishra, P. R. 2015. An insight into functionalized calcium based inorganic nanomaterials in biomedicine: Trends and transitions. Colloids and Surfaces B: Biointerfaces, 133, 120–139.
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  • Shi, J., Xu, Y., Xu, X., Zhu, X., Pridgen, E., Wu, J., Votruba, A. R., Swami, A., Zetter, B. R., Farokhzad, O. C. 2014. Hybrid lipid–polymer nanoparticles for sustained siRNA delivery and gene silencing. Nanomedicine: Nanotechnology, Biology and Medicine, 10(5), 897-900.
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  • Zanin, H., Hollanda, L. M., Ceragioli, H. J., Ferreira, M. S., Machado, D., Lancellotti, M., Catharino, R. R., Baranauskas, V., ve Lobo, A. O. 2014. Carbon nanoparticles for gene transfection in eukaryotic cell lines. Materials Science and Engineering: C, 39, 359–370.
  • Zhang, J., Li, X., ve Huang, L. 2014. Non-viral nanocarriers for siRNA delivery in breast cancer. Journal of Controlled Release, 190, 440–450.
  • Zhang, J., Sun, X., Shao, R., Liang, W., Gao, J., ve Chen, J. 2015. Polycation liposomes combined with calcium phosphate nanoparticles as a non-viral carrier for siRNA delivery. Journal of Drug Delivery Science and Technology, 30, 1–6.
  • Zhang, R., Zheng, N., Song, Z., Yin, L., ve Cheng, J. 2014. The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides. Biomaterials, 35(10), 3443–3454.
  • Zou, L., Song, X., Yi, T., Li, S., Deng, H., Chen, X., Li, Z., Bai, Y., Zhong, Q., Wei, Y., ve Zhao, X. 2013. Administration of PLGA nanoparticles carrying shRNA against focal adhesion kinase and CD44 results in enhanced antitumor effects against ovarian cancer. Cancer Gene Therapy, 20(4), 242–250.
Toplam 102 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Ayşenur PAMUKCI Bu kişi benim

Hüseyin PORTAKAL Bu kişi benim

Erdal EROĞLU

Yayımlanma Tarihi 30 Aralık 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 11 Sayı: 3

Kaynak Göster

APA PAMUKCI, A., PORTAKAL, H., & EROĞLU, E. (2018). Terapötik Moleküllerin Aktarımında Kullanılan Yeni Nesil Biyomalzemeler. Erzincan University Journal of Science and Technology, 11(3), 524-542. https://doi.org/10.18185/erzifbed.339405