Determination of Nifedipine in Pharmaceutical Preparations by Square Wave Voltammetry Method

Yıl 2024, Cilt: 17 Sayı: 3, 688 - 702, 31.12.2024

Bilal Yılmaz

https://doi.org/10.18185/erzifbed.1285704

Öz

Bu çalışmada, nifedipinin elektroanalitik davranışı döngüsel voltametri yöntemiyle incelenmiştir. Prosedür, susuz çözeltilerde bir platin elektrotta elektrokimyasal olarak oksitlenen nifedipine dayanıyordu. 1.16 V'ta oksidasyon tepe noktası kaydedildi. Nifedipinin oksidasyonunun difüzyon kontrollü olduğu keşfedildi. Ek olarak, farmasötik preparasyonlarda nifedipini belirlemek için bu çalışmada hızlı ve kolay bir Kare Dalga Voltametri yöntemi geliştirildi ve valide edildi. 5 ve 50 µg/mL arasındaki konsantrasyonlarda kalibrasyon eğrisi doğrusaldı. Kesinlik bağıl standart sapma ile verildi ve %3.96'dan azdı. Doğruluk bağıl hata ile verildi ve %2.00'yi geçmedi. Farmasötik preparasyonlarda, nifedipinin ortalama geri kazanımı %100.6'dır. Seçilen deneysel koşullar altında, hiçbir girişim bulunmadı. Önerilen yöntem son derece doğru ve kesindir. Bu nedenle yöntem, farmasötik müstahzar olarak Adalat Crono tabletlerdeki nifedipin ölçümüne uygulanabilir.

Anahtar Kelimeler

Nifedipine, voltammetry, validation, tablet

Teşekkür

The author also appreciates Semih Yilmaz's assistance with proper English usage.

Kaynakça

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