ANTIBACTERIAL EFFECT OF SOME 3 -IMINO-4-SUBSTITUTED-1,2,5- THIADIAZOLIDINE 1,1-DIOXIDES

Yıl 2020, Cilt: 9 Sayı: 2, 255 - 264, 30.07.2020

Elif Çil , Ceren Börçek Kasurka , Aliye Gediz Erturk , Seval Kontaş

https://doi.org/10.18036/estubtdc.561008

Öz

Organosulfur compound's functionality constitutes an essential class of therapeutic agents in current medicinal chemistry. Especially sulfonamides called sulfa drugs were performed as both chemotherapeutic agents and useful antibacterial derivatives developed for medicine. The sulfamides in the same family with the sulfonamides have similar biological activities. In our research, it was studied with some 3-imino-4-substituted-1, 2, 5-thiadiazolidine 1,1-dioxides (ISTDs- 4a-d, four samples) that are five-membered cyclosulfamides. These compounds were previously synthesized and structurally characterized. The goals of this study are to investigate minimum inhibition concentration (MIC) values and antibacterial effects of these ISTDs compounds on Bacillus subtilis NRRL B-209T, Escherichia coli ATCC®25922T, Micrococcus luteusNRRL B-1018T, Nocardia abscessus DSM 44432T, Nocardia cyriacigeorgica DSMZ 44484T, Pseudomonas aeruginosa NRRL B-2679T Staphylococcus aureus ATCC®6538T, Streptomyces murinus ISP 5091T.

Anahtar Kelimeler

Nocardia, sulfonamides, microdilution MIC, MBC

Destekleyen Kurum

Ordu Universitesi BAP Birimi

Proje Numarası

AR-1532

Teşekkür

Ordu University Scientific Research Project Commission, which supported this study (Scientific Research Project No: AR-1532)

Bazı 3-imino-4-sübstitüe-1,2,5-tiroidyazolidin 1,1-dioksitlerin antibakteriyel etkisi

Öz

Organosülfür bileşiklerinin işlevselliği, mevcut tıbbi
kimyada önemli bir terapötik madde sınıfını oluşturur. Özellikle sülfa ilaçlar
adı verilen sülfonamitler hem kemoterapötik ajanlar hem de tıp için
geliştirilen etkili antibakteriyel türevler olarak gerçekleştirilmiştir.
Sülfonamidlerle aynı ailedeki sülfamitler benzer biyolojik aktivitelere
sahiptir. Araştırmamızda, beş üyeli siklosülfamitler olan bazı 3-imino-4-ikame
edilmiş-1,2,5-tiadiazolidin 1,1-dioksitler (ISTD'ler-4a-d, dört örnek) ile
çalışılmıştır. Bu bileşikler daha önce sentezlenmiş ve yapısal olarak
karakterize edilmiştir. Bu çalışmanın amacı, Minimum inhibisyon konsantrasyon
(MİK) değerlerini ve bu ISTD bileşiklerinin antibakteriyel etkilerini Bacillus
subtilis NRRL B-209, Escherichia coli ATCC®25922, Micrococcus luteus NRRL
B-1018, Nocardia abscessus DSM 44432, Nocardia cyriacigeorgica DSMZ 44484,
Pseudomonas aeruginosa NRRL B-2679 Staphylococcus aureus ATCC®6538,
Streptomyces murinus ISP 5091 üzerinde araştırmaktır.

Anahtar Kelimeler

Nocardia, sülfonamit, mikrodilüsyon MIC, MBC

Proje Numarası

AR-1532

Kaynakça

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