THROMBOCYTE INDICES RELATION WITH GESTATIONAL HYPERTENSIVE DISORDERS

Yıl 2020, Cilt: 5 Sayı: 1, 121 - 130, 16.01.2020

Mustafa Ayhan Ekici Mehmet Kayhan

https://doi.org/10.35232/estudamhsd.653993

Cited By: 1

Öz

The aim of this study to evaluate relationship between
thrombocyte indices, Red cell distribution width (RDW) and gestational
hypertensive disorders. This study is a retrospective cross sectional study
performed between 2009 - 2019.Total 583 pregnant women were included in this
study; 123 severe preeclampsia (PE), 175 mild-PE, 73 gestational hypertension
(GH), 41 chronic hypertension and 171 healthy pregnant women (control group).
Statistical Package for Social Science version 23.0 is used for statistical
analysis. Kolmogorov-Smirnov, Anova, Kruskal-Wallis and Mann Whitney U tests
are used for interpretation of data. Statistical significance is considered if
p < 0.05. Mean age and number of pregancies were indifferent among five
groups. Mean Platelet Volume (MPV) was significantly higher in severe-PE group
(p<0.001) and insignificantly different among mild-PE, GH, chronic
hypertension and control groups (p=0.116) . Platelet count (PC) was found
significantly lower in severe-PE group (p=0.01) and found indifferent among
mild-PE, GH, chronic hypertension and control groups (p=0.110). RDW was found
significantly higher in severe-PE group than other groups (p=0.01)and
significantly higher in mild-PE group than GH, chronic hypertension and control
groups (p=0.01) but insignificantly different among GH, chronic hypertension
and control groups (p=0.501). Platelet distribution width (PDW) was found
significantly lower in control group than other groups (p<0.001) and found
indifferent among mild-PE, GH, chronic hypertension and severe-PE groups
(p=0.621). Neutrophil lymphocyte ratio (NLR), hemoglobin, Plateletcrit and
Platelet lymphocyte ratio (PLR) were found unchanged among the groups. MPV,
RDW, PDW, NLR, PC, Plateletcrit and PLR were indifferent among GH and chronic
hypertension groups. MPV and RDW were found higher and PC was found lower in
severe-PE. RDW levels elevation was found higher in accordance with the
severity of preeclampsia. PDW was found higher in gestational hypertensive
disorders than healthy pregnant women.                        

Anahtar Kelimeler

Preeclampsia, hypertension, thrombocyte indices, MPV, PDW, RDW, NLR

GESTASYONEL HİPERTANSİF BOZUKLUKLAR ile TROMBOSİT BELİRTEÇLERİNİN İLİŞKİSİ / THROMBOCYTE INDICES RELATION WITH GESTATIONAL HYPERTENSIVE DISORDERS

Öz

Çalışmanın amacı trombosit indeksleri, eritrosit  dağılım genişliği (RDW) ve gestasyonel
hipertansif bozukluklar arasındaki ilişkiyi değerlendirmektir. Çalışma
2009-2019 yılları arasında yapılan retrospektif kesitsel bir çalışmadır. Toplam
583 hamile kadın çalışmaya dahil edildi; 123 şiddetli preeklampsi (PE), 175
hafif PE, 73 gestasyonel hipertansiyon (GH), 41 kronik hipertansiyon ve 171
sağlıklı gebe (kontrol grubu). Verilerin yorumlanmasında Kolmogorov-Smirnov,
ANOVA, Kruskal-Wallis ve Mann Whitney U testleri kullanılmıştır. İstatistiksel
anlamlılık p <0.05 olduğunda kabul edildi. Ortalama yaş ve gebelik sayısı
açısından beş grup arasında fark bulunmadı. Ortalama Trombosit Hacmi (MPV)
şiddetli PE grubunda anlamlı derecede yüksek (p <0.001) bulundu. Hafif PE,
GH, kronik hipertansiyon ve kontrol grupları arasında MPV değerleri anlamlı
derecede farklı değildi (p = 0.116). Trombosit sayısı (PC) şiddetli PE grubunda
anlamlı olarak düşük bulundu (p = 0.01). Hafif PE, GH, kronik hipertansiyon ve
kontrol grupları arasında PC değerleri arasında anlamlı farlılık bulunmadı
(p=0.110). RDW, şiddetli PE grubunda diğer gruplardan (p = 0.01), hafif PE
grubunda GH, kronik hipertansiyon ve kontrol gruplarından (p = 0.01) anlamlı
olarak daha yüksek bulundu. Gestasyonel hipertansiyon, kronik hipertansiyon ve
kontrol grupları arasında RDW değerleri anlamlı derecede farklı bulunmadı. (p=
0.501). Trombosit dağılım genişliği (PDW) kontrol grubunda diğer gruplara göre
anlamlı olarak düşük bulundu (p <0.001). Hafif PE, GH, kronik hipertansiyon
ve şiddetli PE grupları arasında PDW değerleri arasında farklılık bulunmadı (p
= 0.621). Nötrofil lenfosit oranı (NLR), hemoglobin, Trombosit ve Trombosit
lenfosit oranı (PLR) gruplar arasında farklılık göstermedi. MPV, RDW, PDW, NLR,
PC, Trombosit ve PLR değerleri GH ve kronik hipertansiyon grupları arasında
farlılık göstermedi. Şiddetli PE'de MPV ve RDW daha yüksek ve PC daha düşük
bulundu. Preeklempsi şiddeti arttıkça RDW düzeylerinde artış olmaktadır.
Gestasyonel hipertansif hastalıklarda RDW seviyeleri sağlıklı gebelerden daha
yüksek bulunmuştur.                                                

Anahtar Kelimeler

Preeklampsi, hipertansiyon, trombosit indeksleri, MPV, PDW, RDW, NLR

Kaynakça

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