ORTA DOĞU SOLUNUM SENDROMU CORONAVİRÜSÜ SALGINLARI / MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS OUTBREAK

Yıl 2020, Cilt: 5 Sayı: 1, 158 - 167, 16.01.2020

Ahmet Ay

Öz

Derlemenin amacı 2012 yılında yeni tanımlanmış MERS (Orta
Doğu Solunum Sendromu) hastalığı etkeni olan MERS-CoV (Orta Doğu Solunum
Sendromu Coronavirüs) virüsünü tanımak ve günümüze kadar neden olduğu olgu
artışlarını ortaya koymaktır. Aynı Coronavirüs ailesinde yer alan salgın etkeni
SARS’dan (%11) daha yüksek fatalite hızına (%34.4) sahip MERS-CoV salgınları,
ilk tanımlandığından bu yana 27 ülkede, 858 ölüm dahil toplam 2494 olgu ile
küresel bir halk sağlığı tehdidi haline gelmiştir. Özellikle yakın temas ile
bulaşmakta olan MERS-CoV virüsü hastane kaynaklı salgınlara neden olarak
insandan insana yayılabilmektedir.

Anahtar Kelimeler

Salgın haberleri, salgın, MERS-CoV, MERS

MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS OUTBREAK

Öz

The aim of this review is to learn about MERS (Middle East
Respiratory Syndrome) and track its increasing occurence since its first
identification in 2012. The outbreaks of MERS-CoV have a higher fatality rate
(34.4%) than the SARS virus(11%) which is also under the Coronavirus family,
has become a global threat with 2494 cases and 858 deaths across 27 countries
since it was first diagnosed. The virus can be easily transmitted by close
contact and cause hospital based outbreaks, spreading from human to human.

Anahtar Kelimeler

Outbreak news, outbreak, MERS-CoV, MERS

Kaynakça

• 1. Middle East respiratory syndrome coronavirus: World Health Organization; 11 March 2019 [cited 20 December 2019. Available from: https://www.who.int/emergencies/mers-cov/en/
• 2. Middle East Respiratory Syndrome (MERS): Centers for Disease Control and Prevention; 2 August 2019 [cited 20 December 2019. Available from: https://www.cdc.gov/coronavirus/mers/index.html
• 3. Factsheet about Middle East respiratory syndrome coronavirus (MERS-CoV): European Centre for Disease Prevention and Control; 2019 [cited 20 December 2019. Available from: https://www.ecdc.europa.eu/en/middle-east-respiratory-syndrome-coronavirus/factsheet
• 4. Zaki AM, Van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. New England Journal of Medicine. 2012;367(19):1814-20.
• 5. Novel coronavirus infection in the United Kingdom: World Health Organization; 23 September 2012 [cited 15 December 2019. Available from: https://www.who.int/csr/don/2012_09_23/en/
• 6. Bermingham A, Chand M, Brown C, Aarons E, Tong C, Langrish C, et al. Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. Eurosurveillance. 2012;17(40):20290.
• 7. van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, et al. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. MBio. 2012;3(6):e00473-12.
• 8. Al-Abdallat MM, Payne DC, Alqasrawi S, Rha B, Tohme RA, Abedi GR, et al. Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description. Clinical Infectious Diseases. 2014;59(9):1225-33.
• 9. Novel coronavirus infection - update: World Health Organization; 30 November 2012 [cited 15 December 2019. Available from: https://www.who.int/csr/don/2012_11_30/en/
• 10. de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L, et al. Commentary: Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. Journal of virology. 2013;87(14):7790-2.
• 11. Global Alert and Response. Coronavirus infections: World Health Organization; 2019 [cited 20 December 2019. Available from: https://www.who.int/emergencies/mers-cov/en/
• 12. Oboho IK, Tomczyk SM, Al-Asmari AM, Banjar AA, Al-Mugti H, Aloraini MS, et al. 2014 MERS-CoV outbreak in Jeddah—a link to health care facilities. New England Journal of Medicine. 2015;372(9):846-54.
• 13. Kim S, Yang T, Jeong Y, Park J, Lee K, Kim K. Middle East respiratory syndrome coronavirus outbreak in the Republic of Korea, 2015. Osong Public Health Res Perspect. 2016;6(4):269-78.
• 14. Middle East respiratory syndrome coronavirus (MERS-CoV) – Turkey: World Health Organization; 24 October 2014 [cited 15 December 2019. Available from: https://www.who.int/csr/don/24-october-2014-mers/en/
• 15. Bayrakdar F, Altaş AB, Korukluoğlu G, Topal S. Türkiye’de tespit edilen ilk MERS olgusunun moleküler tanısı ve filogenetik analizi. Molecular diagnosis and phylogenetic analysis of the first MERS case in Turkey] Mikrobiyol Bul. 2015;49(3):414-22.
• 16. MERS-CoV situation update: Food and Agriculture Organization (FAO); 18 December 2019 [cited 20 December 2019. Available from: http://www.fao.org/ag/againfo/programmes/en/empres/mers/situation_update.html
• 17. Zumla A, Hui DS, Perlman S. Middle East respiratory syndrome. The Lancet. 2015;386(9997):995-1007.
• 18. King AM, Adams MJ, Carstens EB, Lefkowitz EJ. Virus taxonomy. Ninth report of the International Committee on Taxonomy of Viruses. 2012:486-7.
• 19. Reusken CB, Haagmans BL, Müller MA, Gutierrez C, Godeke G-J, Meyer B, et al. Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. The Lancet infectious diseases. 2013;13(10):859-66.
• 20. Memish ZA, Mishra N, Olival KJ, Fagbo SF, Kapoor V, Epstein JH, et al. Middle East respiratory syndrome coronavirus in bats, Saudi Arabia. Emerging infectious diseases. 2013;19(11):1819.
• 21. Azhar EI, El-Kafrawy SA, Farraj SA, Hassan AM, Al-Saeed MS, Hashem AM, et al. Evidence for camel-to-human transmission of MERS coronavirus. New England Journal of Medicine. 2014;370(26):2499-505.
• 22. Haagmans BL, Al Dhahiry SH, Reusken CB, Raj VS, Galiano M, Myers R, et al. Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation. The Lancet infectious diseases. 2014;14(2):140-5.
• 23. MERS-CoV Hastalığı Sağlık Çalışanları Rehberi: TC Sağlık Bakanlığı Halk Sağlığı Kurumu; Eylül 2017 [cited 15 December 2019. Available from: https://dosyaism.saglik.gov.tr/Eklenti/30925,mers--cov-hastaligi-saglik-calisanlari-rehberipdf.pdf?0
• 24. Falzarano D, De Wit E, Rasmussen AL, Feldmann F, Okumura A, Scott DP, et al. Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques. Nature medicine. 2013;19(10):1313.
• 25. Arabi YM, Balkhy HH, Hayden FG, Bouchama A, Luke T, Baillie JK, et al. Middle East respiratory syndrome. New England Journal of Medicine. 2017;376(6):584-94.
• 26. Alharbi NK, Padron-Regalado E, Thompson CP, Kupke A, Wells D, Sloan MA, et al. ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice. Vaccine. 2017;35(30):3780-8.
• 27. World Health Organization Disease Outbreak News 2019: World Health Organization; 15 December 2019 [cited 15 December 2019. Available from: https://www.who.int/csr/don/archive/year/2019/en/