YÜKSEK YAĞLI DİYETİN AÇLIK-TOKLUK METABOLİZMASINDA GÖREVLİ HORMONLAR VE NÖROPEPTİDLER ÜZERİNE ETKİLERİ

Yıl 2018, Cilt: 27 Sayı: 3, 239 - 344, 25.12.2018

Hilal Hızlı Güldemir

Öz

Günümüzde enerji yoğunluğu ve yağ içeriği yüksek,
vitamin-mineral yönünden fakir besinlerin tüketimi
gittikçe yaygınlaşmakta; bu besinlerin kontrolsüz tüketimi obezite ve diğer metabolik hastalıklara zemin hazırlamaktadır. Besin alımı; merkezi sinir sistemi,
periferal sinyaller, duyusal uyarıcılar gibi pek çok yolla
düzenlenir. Hipotalamusta bir yanıt oluşturarak açlığın,
tokluğun ve besin alımının düzenlenmesinde rol oynayan; ghrelin, nöropeptid-Y, agouti ilişkili peptid, melanin
konsantre edici hormon, oreksin, galanin, opioidler,
leptin, insülin, glukagon benzeri peptid-1,
kolesistokinin, kokain amfetamin düzenleyici transkript,
α-melanosit stimule edici hormon, serotonin,
kortikotropin salgılattırıcı faktör, nesfatin-1, bombesin
gibi nöropeptidler tanımlanmıştır. Yüksek yağlı bir diyetle beslenmenin bunlar ve benzeri öğeler üzerine olan
etkilerinin daha iyi anlaşılması iştah kontrolü ve enerji
dengesinin düzenlenmesi açısından önem taşımaktadır.  

Anahtar Kelimeler

iştah, enerji, yüksek yağlı diyet, hipotalamus, nöropeptid

EFFECTS OF HIGH FAT DIET ON HORMONES AND NEUROPEPTIDES RELATED HUNGER AND SATIETY METABOLISM

Öz

Nowadays the consumption of high fat, low vitaminmineral density foods have been gradually increasing.
The uncontrolled consumption of these kind of foods
leads widespread of obesity and other metabolic
diseases. Food intake is regulated by many factors such
as central nervous system, peripheral signals and
sensory stimuli. Many neuropeptides, namely ghrelin,
neuropeptid-Y, agouti-related peptide, melanin
concentrating hormone, oreksin, galanin, opioids,
leptin, insulin, glukagon like peptide-1, cholecystokinin,
cocain-amfetamin regulated transkript, α-melanocyte
stimulated hormone, serotonin, corticotropin relasing
factor, nesfatin-1, bombesin, that function through
hypotalamus on hunger, satiety and food intake have
been described. A better understanding of the effects of
the high fat diet on these parameters is important in
regulating appetite control and energy balance.

Anahtar Kelimeler

appetite, energy, high fat diet, hypotalamus, neuropeptide

Kaynakça

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