BibTex RIS Kaynak Göster

ZEYTİN YAPRAĞINDAKİ OLEUROPEİN ve FARMAKOLOJİK ETKİLERİ

Yıl 2017, Cilt: 26 Sayı: 1, 89 - 93, 01.03.2017

Öz

Olea europaea L., zeytin, Oleaceae (Zeytingiller)
familyasının bir üyesidir. Zeytin yaprağı, bir sekoiridoit
olan ve antioksidan, antimikrobiyal, antienflamatuvar,
antiaterojenik, antikarsinojenik ve antiviral de dahil bir
çok farmakolojik aktivite göstermesinden sorumlu olan
oleuropein taşımaktadır. Üretici ülke konumunda olan
Türkiye için zeytin, ekonomik ve sosyal açıdan önemli
ürünlerden birisidir. Ülkemizin potansiyeli dikkate alındığında, oleuropein eldesi ve oleuropein ile yapılacak
bilimsel çalışmalarda ülkemiz oldukça önemli bir yere
sahiptir. Yapılmış çalışmalar göz önüne alındığında,
oleuropeinin önemli biyolojik aktivitelere sahip olduğu
ve günümüzde yeni ilaçların geliştirilmesine ışık tutacağı ayrıca eczacılık teknolojisiyle buluşturulup daha
etkili formülasyonların geliştirilip standart farmasötik
formlarda sunulmasının bilim dünyası ve ülke ekonomisine katkı sağlayacağı düşünülmektedir. Bu çalışmada, Oleaceae familyasına dahil olan zeytin yaprağında
yer alan oleuropeinin farmakolojik aktivitelerinin de
içinde bulunduğu çeşitli çalışmalar derlenmiştir. Oleuropein ile yapılan çalışmalar özetlenerek yeni çalışmalara katkı sağlamak amaçlanmıştır

Kaynakça

  • Baytop T. Türkiye’de Bitkiler ile Tedavi Geçmişte ve Bugün (2. baskı). Nobel Tıp Kitabevi İstanbul 1999; s 369.
  • Bedestenci HÇ, Vuruş H. Türkiye'de zeytin üretimi ve geleceği. FMD 2000; 3:136-144.
  • Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm 2010; 78 (2):133-154.
  • Kartal M, Yüzbaşıoğlu M. Olea europaea (Zeytin). Kitap: FFD Monografları Tedavide Kullanılan Bitkiler (2. Baskı). MN Medikal&Nobel Ankara 2011; ss 443-448.
  • Fleming T. PDR for herbal medicines (1st ed). Medical Economics Company 1998; pp 556-557.
  • Markin D, Duek L, Berdicevsky I. In vitro antimicrobial activity of olive leaves. Mycoses 2003; 46(3-4):132-136.
  • Singh I, Mok M, Christensen AM, et al. The effects of polyphenols in olive leaves on platelet function. Nutr Metab Cardiovasc Dis 2008; 18 (2):127-132.
  • Castillo J, Alcaraz M, Benavente-García O. Antioxidant and radioprotective effects of olive leaf extract. Olives and Olive oil in health and disease prevention. Academic Press Oxford 2010; 951-958.
  • Khayyal MT, El-Ghazaly MA, Abdallah DM, et al. Blood pressure lowering effect of an olive leaf extract {Olea europaed) in L-NAME induced hypertension in rats. Arzneimittelforschung 2002; 52(11):797-802.
  • Zaslaver M, Offer S, Kerem Z, et al. Natural compounds derived from foods modulate nitric oxide production and oxidative status in epithelial lung cells. J Agric Food Chem 2005; 53(26):9934- 9939.
  • Christian MS, Sharper VA, Hoberman AM, et al. The toxicity profile of hydrolyzed aqueous olive pulp extract. Drug Chem Toxicol 2004; 27(4):309- 330.
  • Gikas E, Bazoti FN, Tsarbopoulos A. Conformation of oleuropein, the major bioactive compound of Olea europea. J Mol Struct: Theochem 2007; 821 (1):125-132.
  • Li X, Liu Y, Jia Q, et al. A systems biology approach to investigate the antimicrobial activity of oleuropein. J Ind Microbiol Biotechnol 2016; 43 (12):1705-1717.
  • Visioli F, Poli A, Galli C. Antioxidant and other biological activities of phenols from olives and olive oil. Med Res Rev 2002; 22:65–75.
  • Visioli F, Galli C. Olive oil phenols and their potential effects on human health. J Agric Food Chem 1998; 46:4292-4296.
  • Owen RW, A Giacosa, WE Hull, et al. Olive oil consumption and health: the possible role of antioxidants. Lancet Oncol 2000; 21:107–112.
  • Hassen I, Casabianca H, Hosni K, et al. Biological activities of the natural antioxidant oleuropein: Exceeding the expectation–A mini-review. J Funct Foods 2015; 18:926-940.
  • Zorić N, Kopjar N, Bobnjarić I, et al. Antifungal activity of oleuropein against candida albicans— The in vitro study. Molecules 2016; 21(12):1631.
  • Ahmadvand H, Bagheri S, Tamjidi-Poor A, et al. Effects of oleuropein on lipid peroxidation, lipid profile, atherogenic indices, and paraoxonase 1 status in gentamicin-induced nephrotoxicity in rats. ARYA 2015; 11(2):153.
  • Carluccio MA, Siculella L, Ancora MA, et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation. Arterioscler Thromb Vasc Biol 2003; 23(4):622-629.
  • Hamdi H, Castellon R. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochem Bioph Res Co 2005; 334(3):769-778.
  • Seçme M, Eroğlu C, Dodurga Y, et al. Investigation of anticancer mechanism of oleuropein via cell cycle and apoptotic pathways in SH-SY5Y neuroblastoma cells. Gene 2016; 585(1):93-99.
  • Fredrickson WR. Method and composition for antiviral threrapy with olive leaves. US Patent 2000; 6(117):844.
  • Al-Azzawie HF, Alhamdani MSS. Hypoglycemic and antioxidant effect of oleuropein in alloxan- diabetic rabbits. Life Sci 2006; 78(12):1371-1377.
  • Ahmadvand H, Noori A, Dehnoo MG, et al. Hypoglycemic, hypolipidemic and antiatherogenic effects of oleuropein in alloxan-induced Type 1 diabetic rats. Asian Pac J Trop Dis 2014; 4:421- 425.
  • Armutcu F, Akyol S, Hasgül R, ve ark. Zeytin yaprağının biyolojik etkileri ve tıpta kullanımı. Spatula DD 2011; 1(3):159–165.
  • Pourkhodadad S, Alirezaei M, Moghaddasi M, et al. Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats. J Physiol Sci 2016; 66(5):397-405.
  • Khalatbary AR, Ahmadvand H. Neuroprotective effect of oleuropein following spinal cord injury in rats. Neurol Res 2012; 34(1):44-51.
  • Wainstein J, Ganz T, Boaz M, et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Med Food 2012; 15 (7):605-610.
  • Susalit E, Agus N, Effendi I, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine 2011; 18(4):251-258.
  • Perrinjaquet‐Moccetti, T, Busjahn A, Schmidlin C, et al. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother Res 2008; 22(9):1239-1242.
  • Goulas V, Exarchou V, Troganis AN, et al. Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol Nutr Food Res 2009; 53 (5):600-608.

Oleuropein in Olive Leaf and Its Pharmacologial Effects

Yıl 2017, Cilt: 26 Sayı: 1, 89 - 93, 01.03.2017

Öz

Olea europaea L. is an olive, a member of the Oleaceae
family. Olive leaves contains oleuropein, a sekoiridoide
which is responsible from many pharmacological activities including antioxidant, antimicrobial, antiinflammatory, antiatherogenic, anticarcinogenic and antiviral
activities. For Turkey, as an olive producer country,
olive is one of the economically and socially important
product. Considering its potential in our country, oleuropein has a very important place and the scientific
studies to be done with oleuropein. Taking into account the studies carried out, it is thought that oleuropein has important biological activities and it will
shed light on the development of new drugs nowadays.
Furthermore it is thought that developing more effective formulations and bringing in pharmaceutical technology and presenting them in standard pharmaceutical forms will contribute to the scientific world and the
country's economy. In this review, various studies including the pharmacological activities of oleuropein in
the olive folium included in the Oleaceae family have
been reviewed. It is aimed to summarize the studies
conducted with oleuropein and contribute to new studies.

Kaynakça

  • Baytop T. Türkiye’de Bitkiler ile Tedavi Geçmişte ve Bugün (2. baskı). Nobel Tıp Kitabevi İstanbul 1999; s 369.
  • Bedestenci HÇ, Vuruş H. Türkiye'de zeytin üretimi ve geleceği. FMD 2000; 3:136-144.
  • Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm 2010; 78 (2):133-154.
  • Kartal M, Yüzbaşıoğlu M. Olea europaea (Zeytin). Kitap: FFD Monografları Tedavide Kullanılan Bitkiler (2. Baskı). MN Medikal&Nobel Ankara 2011; ss 443-448.
  • Fleming T. PDR for herbal medicines (1st ed). Medical Economics Company 1998; pp 556-557.
  • Markin D, Duek L, Berdicevsky I. In vitro antimicrobial activity of olive leaves. Mycoses 2003; 46(3-4):132-136.
  • Singh I, Mok M, Christensen AM, et al. The effects of polyphenols in olive leaves on platelet function. Nutr Metab Cardiovasc Dis 2008; 18 (2):127-132.
  • Castillo J, Alcaraz M, Benavente-García O. Antioxidant and radioprotective effects of olive leaf extract. Olives and Olive oil in health and disease prevention. Academic Press Oxford 2010; 951-958.
  • Khayyal MT, El-Ghazaly MA, Abdallah DM, et al. Blood pressure lowering effect of an olive leaf extract {Olea europaed) in L-NAME induced hypertension in rats. Arzneimittelforschung 2002; 52(11):797-802.
  • Zaslaver M, Offer S, Kerem Z, et al. Natural compounds derived from foods modulate nitric oxide production and oxidative status in epithelial lung cells. J Agric Food Chem 2005; 53(26):9934- 9939.
  • Christian MS, Sharper VA, Hoberman AM, et al. The toxicity profile of hydrolyzed aqueous olive pulp extract. Drug Chem Toxicol 2004; 27(4):309- 330.
  • Gikas E, Bazoti FN, Tsarbopoulos A. Conformation of oleuropein, the major bioactive compound of Olea europea. J Mol Struct: Theochem 2007; 821 (1):125-132.
  • Li X, Liu Y, Jia Q, et al. A systems biology approach to investigate the antimicrobial activity of oleuropein. J Ind Microbiol Biotechnol 2016; 43 (12):1705-1717.
  • Visioli F, Poli A, Galli C. Antioxidant and other biological activities of phenols from olives and olive oil. Med Res Rev 2002; 22:65–75.
  • Visioli F, Galli C. Olive oil phenols and their potential effects on human health. J Agric Food Chem 1998; 46:4292-4296.
  • Owen RW, A Giacosa, WE Hull, et al. Olive oil consumption and health: the possible role of antioxidants. Lancet Oncol 2000; 21:107–112.
  • Hassen I, Casabianca H, Hosni K, et al. Biological activities of the natural antioxidant oleuropein: Exceeding the expectation–A mini-review. J Funct Foods 2015; 18:926-940.
  • Zorić N, Kopjar N, Bobnjarić I, et al. Antifungal activity of oleuropein against candida albicans— The in vitro study. Molecules 2016; 21(12):1631.
  • Ahmadvand H, Bagheri S, Tamjidi-Poor A, et al. Effects of oleuropein on lipid peroxidation, lipid profile, atherogenic indices, and paraoxonase 1 status in gentamicin-induced nephrotoxicity in rats. ARYA 2015; 11(2):153.
  • Carluccio MA, Siculella L, Ancora MA, et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation. Arterioscler Thromb Vasc Biol 2003; 23(4):622-629.
  • Hamdi H, Castellon R. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochem Bioph Res Co 2005; 334(3):769-778.
  • Seçme M, Eroğlu C, Dodurga Y, et al. Investigation of anticancer mechanism of oleuropein via cell cycle and apoptotic pathways in SH-SY5Y neuroblastoma cells. Gene 2016; 585(1):93-99.
  • Fredrickson WR. Method and composition for antiviral threrapy with olive leaves. US Patent 2000; 6(117):844.
  • Al-Azzawie HF, Alhamdani MSS. Hypoglycemic and antioxidant effect of oleuropein in alloxan- diabetic rabbits. Life Sci 2006; 78(12):1371-1377.
  • Ahmadvand H, Noori A, Dehnoo MG, et al. Hypoglycemic, hypolipidemic and antiatherogenic effects of oleuropein in alloxan-induced Type 1 diabetic rats. Asian Pac J Trop Dis 2014; 4:421- 425.
  • Armutcu F, Akyol S, Hasgül R, ve ark. Zeytin yaprağının biyolojik etkileri ve tıpta kullanımı. Spatula DD 2011; 1(3):159–165.
  • Pourkhodadad S, Alirezaei M, Moghaddasi M, et al. Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats. J Physiol Sci 2016; 66(5):397-405.
  • Khalatbary AR, Ahmadvand H. Neuroprotective effect of oleuropein following spinal cord injury in rats. Neurol Res 2012; 34(1):44-51.
  • Wainstein J, Ganz T, Boaz M, et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Med Food 2012; 15 (7):605-610.
  • Susalit E, Agus N, Effendi I, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine 2011; 18(4):251-258.
  • Perrinjaquet‐Moccetti, T, Busjahn A, Schmidlin C, et al. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother Res 2008; 22(9):1239-1242.
  • Goulas V, Exarchou V, Troganis AN, et al. Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol Nutr Food Res 2009; 53 (5):600-608.
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA36JH36VF
Bölüm Araştırma Makalesi
Yazarlar

Ayşe Kübra Karaboğa Arslan

Ebru Öztürk Bu kişi benim

M. Betül Yerer Bu kişi benim

Müberra Koşar Bu kişi benim

Yayımlanma Tarihi 1 Mart 2017
Gönderilme Tarihi 1 Mart 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 26 Sayı: 1

Kaynak Göster

APA Karaboğa Arslan, A. K., Öztürk, E., Yerer, M. B., Koşar, M. (2017). ZEYTİN YAPRAĞINDAKİ OLEUROPEİN ve FARMAKOLOJİK ETKİLERİ. Sağlık Bilimleri Dergisi, 26(1), 89-93.
AMA Karaboğa Arslan AK, Öztürk E, Yerer MB, Koşar M. ZEYTİN YAPRAĞINDAKİ OLEUROPEİN ve FARMAKOLOJİK ETKİLERİ. JHS. Mart 2017;26(1):89-93.
Chicago Karaboğa Arslan, Ayşe Kübra, Ebru Öztürk, M. Betül Yerer, ve Müberra Koşar. “ZEYTİN YAPRAĞINDAKİ OLEUROPEİN Ve FARMAKOLOJİK ETKİLERİ”. Sağlık Bilimleri Dergisi 26, sy. 1 (Mart 2017): 89-93.
EndNote Karaboğa Arslan AK, Öztürk E, Yerer MB, Koşar M (01 Mart 2017) ZEYTİN YAPRAĞINDAKİ OLEUROPEİN ve FARMAKOLOJİK ETKİLERİ. Sağlık Bilimleri Dergisi 26 1 89–93.
IEEE A. K. Karaboğa Arslan, E. Öztürk, M. B. Yerer, ve M. Koşar, “ZEYTİN YAPRAĞINDAKİ OLEUROPEİN ve FARMAKOLOJİK ETKİLERİ”, JHS, c. 26, sy. 1, ss. 89–93, 2017.
ISNAD Karaboğa Arslan, Ayşe Kübra vd. “ZEYTİN YAPRAĞINDAKİ OLEUROPEİN Ve FARMAKOLOJİK ETKİLERİ”. Sağlık Bilimleri Dergisi 26/1 (Mart 2017), 89-93.
JAMA Karaboğa Arslan AK, Öztürk E, Yerer MB, Koşar M. ZEYTİN YAPRAĞINDAKİ OLEUROPEİN ve FARMAKOLOJİK ETKİLERİ. JHS. 2017;26:89–93.
MLA Karaboğa Arslan, Ayşe Kübra vd. “ZEYTİN YAPRAĞINDAKİ OLEUROPEİN Ve FARMAKOLOJİK ETKİLERİ”. Sağlık Bilimleri Dergisi, c. 26, sy. 1, 2017, ss. 89-93.
Vancouver Karaboğa Arslan AK, Öztürk E, Yerer MB, Koşar M. ZEYTİN YAPRAĞINDAKİ OLEUROPEİN ve FARMAKOLOJİK ETKİLERİ. JHS. 2017;26(1):89-93.