ZEYTİN YAPRAĞINDAKİ OLEUROPEİN ve FARMAKOLOJİK ETKİLERİ

Öz

Olea europaea L., zeytin, Oleaceae (Zeytingiller) familyasının bir üyesidir. Zeytin yaprağı, bir sekoiridoit olan ve antioksidan, antimikrobiyal, antienflamatuvar, antiaterojenik, antikarsinojenik ve antiviral de dahil bir çok farmakolojik aktivite göstermesinden sorumlu olan oleuropein taşımaktadır. Üretici ülke konumunda olan Türkiye için zeytin, ekonomik ve sosyal açıdan önemli ürünlerden birisidir. Ülkemizin potansiyeli dikkate alındığında, oleuropein eldesi ve oleuropein ile yapılacak bilimsel çalışmalarda ülkemiz oldukça önemli bir yere sahiptir. Yapılmış çalışmalar göz önüne alındığında, oleuropeinin önemli biyolojik aktivitelere sahip olduğu ve günümüzde yeni ilaçların geliştirilmesine ışık tutacağı ayrıca eczacılık teknolojisiyle buluşturulup daha etkili formülasyonların geliştirilip standart farmasötik formlarda sunulmasının bilim dünyası ve ülke ekonomisine katkı sağlayacağı düşünülmektedir. Bu çalışmada, Oleaceae familyasına dahil olan zeytin yaprağında yer alan oleuropeinin farmakolojik aktivitelerinin de içinde bulunduğu çeşitli çalışmalar derlenmiştir. Oleuropein ile yapılan çalışmalar özetlenerek yeni çalışmalara katkı sağlamak amaçlanmıştır

Anahtar Kelimeler

• Olea europea L., oleuropein, zeytin yaprağı, tıbbi bitki

Oleuropein in Olive Leaf and Its Pharmacologial Effects

Öz

Olea europaea L. is an olive, a member of the Oleaceae family. Olive leaves contains oleuropein, a sekoiridoide which is responsible from many pharmacological activities including antioxidant, antimicrobial, antiinflammatory, antiatherogenic, anticarcinogenic and antiviral activities. For Turkey, as an olive producer country, olive is one of the economically and socially important product. Considering its potential in our country, oleuropein has a very important place and the scientific studies to be done with oleuropein. Taking into account the studies carried out, it is thought that oleuropein has important biological activities and it will shed light on the development of new drugs nowadays. Furthermore it is thought that developing more effective formulations and bringing in pharmaceutical technology and presenting them in standard pharmaceutical forms will contribute to the scientific world and the country's economy. In this review, various studies including the pharmacological activities of oleuropein in the olive folium included in the Oleaceae family have been reviewed. It is aimed to summarize the studies conducted with oleuropein and contribute to new studies.

Anahtar Kelimeler

• Olea europea L., oleuropein, olive folium, medicinal plants

Kaynakça

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