BibTex RIS Kaynak Göster

IS THERE A RELATION BETWEEN ZINC LEVELS, AND RECURRENT RESPIRATORY SYSTEM I NFECTIONS IN CHILDREN?

Yıl 2018, Cilt: 27 Sayı: 1, 36 - 39, 01.03.2018

Öz

Amaç: Eser elementlerin ve D vitaminin eksik alımı ve
allerji çocuk solunum sistemi sağlığı üzerine etkileri bulunmaktadır. Kesitsel çalışmamızda tekrar eden solunum yolun yolu enfeksiyonu ile çinko düzeyleri ve neden olabilecek diğer faktörlerin ilişkisini araştırmak amaçlanmaktadır.
Metod: 2015-2017 tekrar eden akut otitis media, farenjit,
rinit gibi üst solunum yolu enfeksiyonu ve alt solunum yolu
enfeksiyonu olan, Türkiye’de yaşayan 249 olgu ve 122
sağlıklı kontrol çalışmaya dahil edilmiştir. Çinko düzeyleri,
adenoid hipertrofi varlığı allerji deri testi, yaş, cinsiyet,
tekrar eden alt veya üst solunum yolu enfeksiyonu öyküsü
değerlendirilmiştir.
Sonuçlar: 180 kız, 191 erkek olmak üzere 371 olgu
(ortalama ± SD, 47±31 ay), çalışmaya dahil edilmiştir. Tekrar eden üst ve alt solunum yolu enfeksiyonu ile çinko düzeyleri (ortalama ± SD, 0,88±0,28), (ortalama ± SD,
0,88±0,35), arasında anlamlı ilişki saptanmamıştır. Tekrar
eden solunum yolu enfeksiyonu olan olgular ile sağlıklı
grup arasında, IgE düzeyleri açısından anlamlı istatistiksel
fark bulunmamıştır (p=0,4). D vitamini düzeyleri tekrar
eden alt ve üst solunum yolu enfeksiyonu olan grupta anlamlı olarak düşük bulunmuştur(p=0,001).
Sonuç: Sağlıklı kontroller ile tekrar eden solunum yolu
enfeksiyonu olan olgular arasında çinko düzeyleri açısından anlamlı fark saptanmamıştır. Tekrar eden solunum
yolu enfeksiyonunda çinko suplementasyonu ancak eksikliği saptanmış olgulara önerilebilir, ve bu olgular tekrar
eden solunum yolu enfeksiyonunda bağımsız risk faktörü
olan adenoid hipertrofi varlığı açısından değerlendirilmelidir.

Kaynakça

  • 1. Saglani S, Bush A. The early-life origins of asthma. Curr Opin Allergy Clin Immunol 2007; 7:83-90
  • 2. Allen S, Britton JR, Leonardi-Bee JA. Association between antioxidant vitamins and asthma outcome measures:systematic review and meta-analysis. Thorax 2009; 64:610-619
  • 3. Maret W. Zinc biochemistry:from a single zinc enzyme to a key element of life. Adv Nutr 2013; 1:82 -91
  • 4. Dreosti IE. Recommended dietary intakes of iron, zinc and other inorganic nutrients and their chemical form and bioavailability. Nutrition 1993; 9 6:542-545
  • 5. Prasad AS. Discovery of human Zinc deficiency: its impact on human health and disease. Adv Nutr 2013; 4:176-190
  • 6. Yılmaz EA, Ozmen S, Bostanci I, Mısırlıoğlu ED, Ertan U. Erythrocyte zinc levels in children with bronchial asthma. Pediatr Pulmonol 2011; 46: 1189-1193
  • 7. Urushidate S, Matzuka M, Ukobo N, et al. Association between concentration of trace elements in serum and bronchial asthma among Japaneese general population. J Trace Elem Med Biol 2010; 244:236- 242
  • 8. Van Oeffellen AA, Bekkers MB, Smit HA, et al. Micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol 2011; 22:784-793
  • 9. Allan K, Devereux G. Diet and asthma:nutrition implications from prevention to tretament. J Am Diet Assoc 2011; 111:258-268
  • 10. Beck FW, Li Y, Bao B, et al. Evidence for reprogramming global gene expression during zinc deficiency in the HUT-78 cell line. Nutrition 2006; 22:1045-1056
  • 11. Cousins RJ, Blanchard RK, Popp MP, et al. A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells. Proc Natl Acad Sci USA 2003; 100:6952-6957
  • 12. Haase H, Mazzatti DJ, White A, et al. Differential gene expression after zinc supplementation and deprivation in human leucocyte subsets. Mol Med 2007; 13:362-370
  • 13. Girodon F, Galan P, Monget AL, et al. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. Geriatric network. Arch Intern Med 1999; 159:748-754
  • 14. Darrow DH, Siemens C. Indications for tonsillectomy and adenoidectomy, Laryngoscope 112 (2002) 6-10, http://dx.doi.org/10.1002
  • 15. Worley NK, Abdalkhani A, Hagmann MA, et al. Gold Laser versus curettage adenoidectomy: incidence of complications and otorhea after concurrent pressure -equalization tube placement. Laryngoscope 2007;117:2026-2029.
  • 16. Anand V, Sarin B, Singh B. Changing trends in adenoidectomy. Indian J Otorhinolaryngol Head Neck Surg 2014; 66:375-380.
  • 17. Bartley J. Vitamin D, innate immunity and upper respiratory tract infection. J laryngol Otol 2011; 124:1255-1260.
  • 18. Reid D, Morton R, Salkeld L. Vitamin D and tonsil disease-preeliminary observations. Int J Ped Otorhinolaryngol 2011; 75:261-264.
  • 19. 20. Silva Rde C, Assis AM, Goncalves MS, et al.The prevalence of wheezing and its association with body mass index and abdominal obesity in children. J Asthma 2013;50:267-273.
  • 20. 21.Patel S, Murray CS, Woodcock A, et al. Dietary antioxidant intake, allergic sensitization and allergic diseases in young children. Allergy 2009;6:1766- 1772.
  • 21. Liu J, Ai YX, Hanlon A, Shi Z, Dickerman B, Compher C. Micronutrients deficiency and associated sociodemographic factors in Chinese children. World J Pediatr 2011;7:217-223.
  • 22. Asare GA, Nani A. Serum levels of Cu, Se, and Zn in adult rural/urban residents in Ghana:paradigm shift? Biol Trace Elem Res 2010; 137:139-149.
  • 23. Razi CH Akelma AZ, Akin O, et al. Hair zinc and selenium levels in children with recurrent wheezing. Pediatr Pulmonol 2012;47:1185-1191.
  • 24. Klanbabaee G, Omidian A, Imanzadeh F, et al. Serum level of zinc in asthatic patients: a case control study. Allergol Immunopathol 2013; 42:19-21.
  • 25. Taussig, Landau, Le Souef, et al. Pediatric respiratory Medicine Chapter 2nd edition. Mosby ElsevierChapter 63, pp891
  • 26. Huang L, Tepaamorndech S. The SLC30 family of zinc transporters- a review of current understanding of their biological and pathophysiological roles. Mol Aspects Med 2013;34:548.
  • 27. Wang L, Song Y. Efficacy of zinc given as an adjunct to the treatment of severe pneumonia: a metaanalysis of randomized double-blind and placebocontrolled trials. Clin Respir J 2017 doı: 10.1111/ crj.12646

Çocuklarda Çinko Düzeyleri İle Tekrar Eden Solunum Yolu Enfeksiyonu Arasında İlişki Var Mıdır?

Yıl 2018, Cilt: 27 Sayı: 1, 36 - 39, 01.03.2018

Öz

Objective: There are many consequences connected with an
inadequate intake of trace elements and Vitamin D. Allergic
disorders and a susceptibility to respiratory infections may
be related to deficiencies of trace elements and/or vitamin
D. This cross-sectional study aims to investigate associations between recurrent respiratory system infections and
Zinc levels; as well as other dependent factors.
Methods: Three hundred and seventy one children living in
Turkey were enrolled in the study between 2015 and 2017.
Two hundred and forty nine had a history of either recurrent upper respiratory infections such as, acute otitis media, pharyngitis, rhinitis, or lower respiratory tract infections. 122 were considered as healthy controls. Age, gender, existence of adenoid hypertrophy, upper and lower
respiratory tract infections, zinc levels, vitamin D levels, IgE
levels, and a skin prick test were all evaluated.
Results: A total of 371 children (mean age ± standard deviation = 47±31 months), 180 males and 191 females were
included. No significant difference between the zinc levels
of children with recurrent upper (mean ± standard deviation = 0,88±0,28) respiratory tract infections and lower
respiratory tract (mean ±standard deviation= 0,88±0,35)
infections was observed. Likewise, there was no significant
difference between IgE levels of children with recurrent
respiratory tract infections and healthy controls (p=0,4).
Vitamin D levels, however, were found to be significantly
lower in children with lower and upper respiratory tract
infections (p=0,001).
Conclusion: There was no significant difference in zinc levels between healthy controls and children with recurrent
respiratory tract infections. However, if there is a documented low zinc deficiency, children with recurrent respiratory tract infections may be recommended a zinc supplementation protocol. Additionally, these children should also
be monitored for adenoid hypertrophy; an independent
risk factor for recurrent respiratory tract infections.

Kaynakça

  • 1. Saglani S, Bush A. The early-life origins of asthma. Curr Opin Allergy Clin Immunol 2007; 7:83-90
  • 2. Allen S, Britton JR, Leonardi-Bee JA. Association between antioxidant vitamins and asthma outcome measures:systematic review and meta-analysis. Thorax 2009; 64:610-619
  • 3. Maret W. Zinc biochemistry:from a single zinc enzyme to a key element of life. Adv Nutr 2013; 1:82 -91
  • 4. Dreosti IE. Recommended dietary intakes of iron, zinc and other inorganic nutrients and their chemical form and bioavailability. Nutrition 1993; 9 6:542-545
  • 5. Prasad AS. Discovery of human Zinc deficiency: its impact on human health and disease. Adv Nutr 2013; 4:176-190
  • 6. Yılmaz EA, Ozmen S, Bostanci I, Mısırlıoğlu ED, Ertan U. Erythrocyte zinc levels in children with bronchial asthma. Pediatr Pulmonol 2011; 46: 1189-1193
  • 7. Urushidate S, Matzuka M, Ukobo N, et al. Association between concentration of trace elements in serum and bronchial asthma among Japaneese general population. J Trace Elem Med Biol 2010; 244:236- 242
  • 8. Van Oeffellen AA, Bekkers MB, Smit HA, et al. Micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol 2011; 22:784-793
  • 9. Allan K, Devereux G. Diet and asthma:nutrition implications from prevention to tretament. J Am Diet Assoc 2011; 111:258-268
  • 10. Beck FW, Li Y, Bao B, et al. Evidence for reprogramming global gene expression during zinc deficiency in the HUT-78 cell line. Nutrition 2006; 22:1045-1056
  • 11. Cousins RJ, Blanchard RK, Popp MP, et al. A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells. Proc Natl Acad Sci USA 2003; 100:6952-6957
  • 12. Haase H, Mazzatti DJ, White A, et al. Differential gene expression after zinc supplementation and deprivation in human leucocyte subsets. Mol Med 2007; 13:362-370
  • 13. Girodon F, Galan P, Monget AL, et al. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. Geriatric network. Arch Intern Med 1999; 159:748-754
  • 14. Darrow DH, Siemens C. Indications for tonsillectomy and adenoidectomy, Laryngoscope 112 (2002) 6-10, http://dx.doi.org/10.1002
  • 15. Worley NK, Abdalkhani A, Hagmann MA, et al. Gold Laser versus curettage adenoidectomy: incidence of complications and otorhea after concurrent pressure -equalization tube placement. Laryngoscope 2007;117:2026-2029.
  • 16. Anand V, Sarin B, Singh B. Changing trends in adenoidectomy. Indian J Otorhinolaryngol Head Neck Surg 2014; 66:375-380.
  • 17. Bartley J. Vitamin D, innate immunity and upper respiratory tract infection. J laryngol Otol 2011; 124:1255-1260.
  • 18. Reid D, Morton R, Salkeld L. Vitamin D and tonsil disease-preeliminary observations. Int J Ped Otorhinolaryngol 2011; 75:261-264.
  • 19. 20. Silva Rde C, Assis AM, Goncalves MS, et al.The prevalence of wheezing and its association with body mass index and abdominal obesity in children. J Asthma 2013;50:267-273.
  • 20. 21.Patel S, Murray CS, Woodcock A, et al. Dietary antioxidant intake, allergic sensitization and allergic diseases in young children. Allergy 2009;6:1766- 1772.
  • 21. Liu J, Ai YX, Hanlon A, Shi Z, Dickerman B, Compher C. Micronutrients deficiency and associated sociodemographic factors in Chinese children. World J Pediatr 2011;7:217-223.
  • 22. Asare GA, Nani A. Serum levels of Cu, Se, and Zn in adult rural/urban residents in Ghana:paradigm shift? Biol Trace Elem Res 2010; 137:139-149.
  • 23. Razi CH Akelma AZ, Akin O, et al. Hair zinc and selenium levels in children with recurrent wheezing. Pediatr Pulmonol 2012;47:1185-1191.
  • 24. Klanbabaee G, Omidian A, Imanzadeh F, et al. Serum level of zinc in asthatic patients: a case control study. Allergol Immunopathol 2013; 42:19-21.
  • 25. Taussig, Landau, Le Souef, et al. Pediatric respiratory Medicine Chapter 2nd edition. Mosby ElsevierChapter 63, pp891
  • 26. Huang L, Tepaamorndech S. The SLC30 family of zinc transporters- a review of current understanding of their biological and pathophysiological roles. Mol Aspects Med 2013;34:548.
  • 27. Wang L, Song Y. Efficacy of zinc given as an adjunct to the treatment of severe pneumonia: a metaanalysis of randomized double-blind and placebocontrolled trials. Clin Respir J 2017 doı: 10.1111/ crj.12646
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA94AA33TK
Bölüm Araştırma Makalesi
Yazarlar

Özlem Naciye Şahin Bu kişi benim

Nuray Keçecioğlu Bu kişi benim

Muhittin Serdar Bu kişi benim

Aysel Özpınar Bu kişi benim

Yayımlanma Tarihi 1 Mart 2018
Gönderilme Tarihi 1 Mart 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 27 Sayı: 1

Kaynak Göster

APA Şahin, Ö. N., Keçecioğlu, N., Serdar, M., Özpınar, A. (2018). IS THERE A RELATION BETWEEN ZINC LEVELS, AND RECURRENT RESPIRATORY SYSTEM I NFECTIONS IN CHILDREN?. Sağlık Bilimleri Dergisi, 27(1), 36-39.
AMA Şahin ÖN, Keçecioğlu N, Serdar M, Özpınar A. IS THERE A RELATION BETWEEN ZINC LEVELS, AND RECURRENT RESPIRATORY SYSTEM I NFECTIONS IN CHILDREN?. JHS. Mart 2018;27(1):36-39.
Chicago Şahin, Özlem Naciye, Nuray Keçecioğlu, Muhittin Serdar, ve Aysel Özpınar. “IS THERE A RELATION BETWEEN ZINC LEVELS, AND RECURRENT RESPIRATORY SYSTEM I NFECTIONS IN CHILDREN?”. Sağlık Bilimleri Dergisi 27, sy. 1 (Mart 2018): 36-39.
EndNote Şahin ÖN, Keçecioğlu N, Serdar M, Özpınar A (01 Mart 2018) IS THERE A RELATION BETWEEN ZINC LEVELS, AND RECURRENT RESPIRATORY SYSTEM I NFECTIONS IN CHILDREN?. Sağlık Bilimleri Dergisi 27 1 36–39.
IEEE Ö. N. Şahin, N. Keçecioğlu, M. Serdar, ve A. Özpınar, “IS THERE A RELATION BETWEEN ZINC LEVELS, AND RECURRENT RESPIRATORY SYSTEM I NFECTIONS IN CHILDREN?”, JHS, c. 27, sy. 1, ss. 36–39, 2018.
ISNAD Şahin, Özlem Naciye vd. “IS THERE A RELATION BETWEEN ZINC LEVELS, AND RECURRENT RESPIRATORY SYSTEM I NFECTIONS IN CHILDREN?”. Sağlık Bilimleri Dergisi 27/1 (Mart 2018), 36-39.
JAMA Şahin ÖN, Keçecioğlu N, Serdar M, Özpınar A. IS THERE A RELATION BETWEEN ZINC LEVELS, AND RECURRENT RESPIRATORY SYSTEM I NFECTIONS IN CHILDREN?. JHS. 2018;27:36–39.
MLA Şahin, Özlem Naciye vd. “IS THERE A RELATION BETWEEN ZINC LEVELS, AND RECURRENT RESPIRATORY SYSTEM I NFECTIONS IN CHILDREN?”. Sağlık Bilimleri Dergisi, c. 27, sy. 1, 2018, ss. 36-39.
Vancouver Şahin ÖN, Keçecioğlu N, Serdar M, Özpınar A. IS THERE A RELATION BETWEEN ZINC LEVELS, AND RECURRENT RESPIRATORY SYSTEM I NFECTIONS IN CHILDREN?. JHS. 2018;27(1):36-9.