Çölyakta Probiyotik ve Prebiyotikler

Yıl 2019, Cilt: 28 Sayı: 3, 177 - 181, 30.12.2019

Nur Bengü Erdem , Aylin Açıkgöz

https://doi.org/10.34108/eujhs.470781

Öz

Çölyak hastalığının toplumdaki görülme sıklığı
yaklaşık olarak %1’dir. Hastalığın tek etkili tedavi yöntemi, yaşam boyu
sürdürülecek glutensiz diyettir. Günümüzde birçok ürünün gluten içermesi ve
glutensiz diyete uyumun zor olması, hastalığın tedavisinde alternatif tedavi
seçeneklerine ihtiyaç duyulmasına yol açmıştır. Çölyak; çevresel ve genetik
faktörlerin etkileşimi sonucunda oluşmaktadır. Gluten proteinleri hastalığın
oluşumunda esas çevresel etmen olmasına rağmen yapılan son çalışmalar bağırsak
mikrobiyotasındaki değişimlerin çölyak oluşumunu etkileyebileceğini
göstermektedir. Çölyak tanılı ve sağlıklı bireylerin mikrobiyota
kompozisyonlarının farklı olması hastalığın oluşumunda mikrobiyotanın etkisine
işaret etmektedir. Değişen bağırsak mikrobiyotasının çölyaktaki düzelmeyen
semptomlarla ilgili olduğu, ayrıca probiyotik ve/veya prebiyotik kullanımının
hastalığın tedavisinde faydalı olabileceği öne sürülmektedir. Bu yazının amacı;
probiyotik ve prebiyotiklerin çölyak hastalığı üzerine etkilerinin güncel literatür
ile derlenmesidir.

Anahtar Kelimeler

Çölyak, glutensiz diyet, bağırsak mikrobiyotası, probiyotik, prebiyotik

Kaynakça

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