Avrupada Kırmızı Tilkilerin (Vulpes Vulpes L)Ağız Yoluyla İmmunizasyonu

Öz

Attenüe virus aşısı kullanılarak kırmızı tilkilerin kuduza karşı immunize edilebilirliğinin prensiplerini gösteren. birçok deneysel çalışmadan sonra tilkilerin ağız yoluyla immunizasyonu ile ilgili ilk saha çalışması. 1978 yılında İsviçre'de başarıyla yürütülmüştür. Geçmişte yürütülen alışılagelmiş kuduz kontrol yöntemlerinin aksine attenüe aşıların potansiyel kullanımı kuduzun kontrolünde yeni bir perspektif sunar görünmektedir. Bundan sonra tilkilerin ağız yoluyla immunizasyonu modifiye canlı aşıların bait üretim sistemlerinin , aşılama stratejilerinin ve bait dağıtımı geliştirilmesi ile ilgili uluslararası araştırmalardaki yoğun çabalardan dolayı Avrupa'da kuduzun kontrolunde seçilen bir metot olarak gelişmiştir. Dünya Sağlık Örgütü ve Avrupa Birliği tarafından desteklenen uluslararası bir işbirliğinin sonucu olarak, tilkilerin ağız yoluyla immunizasyonu uygulamasının katılan ülkelerede kuduzun insidansı belirgin şekilde düşmüştür. Vahşi hayvanlardaki hastalık kontrolüne yönelik bu modern yöntem, temel alınarak tilkilerdeki kuduzun yakın bir gelecekte elemine edileceği tahmin edilmektedir. Bununla birlikte son yıllarda muhtelif Avrupa ülkelerinde aşılama stratejilerindeki eksiklik ve maddi imkanlar nedeniyle kuduz insidansında çok az bir artış görülmüştür. Bu deneyimler göstermektedir ki tilkilerin ağız yoluyla immunizasyonu ile kuduzun tamamen eradikasyonu tahmin edilenden daha uzun sürmekte ve daha komplike olmaktadır. Bu sorunların çözülmesinde gelecekte uluslararası işbirliği (kontrol programları ve araştırmaya yönelik) son derece önemli olup, Avrupa'daki vahşi hayvanlardaki kuduzun eradikasyonu için tilkilerin oral yolla immunizasyonu amacına ulaşılması için güçlendirilmelidir.

Anahtar Kelimeler

• Etlik Veterinerlik Mikrobiyoloji Dergisi
• Avrupa
• Kırmızı Tilki
• Ağız Yolu
• İmmunizalosyon

Oral immunization of Red Foxes (Vulpes vulpes L) in Europe - A Review-

Öz

Many experimental studies showeel the principle possibility of immunizing red foxes against rabies using attenuated virus vaccines. The first field trial concerning oral immunization of foxes (OIF) against rabies was successfully carried out in Switzerland in 1978. In contrast to conventional rnethods of rabies control conducted in the past. the potential use of a tlenuatecl vaccines appeared to offer a new perspective in rabies control. Since then the OIF has been developed into the method of choice in rabies control in Europe due to intensive efforts in international research con cerning iınprovement and further development of modified live virus vaccines. baiting systems. vaccination strategies. and bait distribution systems. As a result of international cooperation with support of the World Healt Organization and the European Union the rabies ineidence has drastically decreased in OIF -participating countries. It is estimatecl that. with this modern method of disease control in wildlife. rabies in foxes could be eliminateel in the near future . However. in recent years, several set-backs were observed resulting in a slight increase in the rabies incidence of cer1ain European counties. These were mainly due to lack of funding and the appliecl vaccination strategies. These experiences indicate that the complete eradication of rabies virus with OIF is more protracted anel more complicatecl than originally assumed. In order to solve these problems. international cooperation (control programmes and research) is of utmost .importance and needs to be strengthened to reach the aim of OIF. the eraclication of rabies in wildlife in Europe.

Kaynakça

1. Artois M, Chilled T, Mallet E (1987) Premiere campagne ele vaccination antirabique du renard par voie orale menee en France - centrole de efficacite chez le renard et innocuite chez les micromanüfereses. Ann. med. vet., 131:457-462
2. Artois M, Charlton KM, Tolson ND, Casey GA, Knowless MK, Campbell JB (1990) Vaccina recombinant virus eA'})ressing the rabies virus glycoprotein: safety anel efficacy trials in Canadian wildlife. Can. J. Vet. Res. 54:504-507
3. Aubert MFA (ı 992) Epiclemiology of fox rabies. In: Wildlife Rabies Control (ecls. Bögel K, Meslin FX, Kaplan Ml 9-18,Wells Medical Ltd. , Kent
4. Bachmann P, Bramwell RN, Fraser SJ, Gilmore DA, Johnston DH, Lawson KF, Maclnnes CD, Matejka FO, Miles HE, Pedde MA, Voigt DR (1990) Wild carnivore acceptance of baits for delivery of liquid rabies vaccine . J. Wilcll. Dis .. 26:486-501
5. Baer GM, Abelseth MK, Debbie JG (1971) Oral vaccination of foxes against rabies. Am. J . Epidemiol., 93:487-490
6. Baer GM, Shaddock JH, Hayes DJ, Savarie P (1985) Iophenoxic acidasa serum marker in carnivores. J . Wildl. Manage., 49:49-51
7. Balser DS (ı964) Management of predator populations with antifertility agents. J . Wildl. Manage., 28:352-358
8. Bingham J, Foggin CM, Gerher H, Hill FWG, Kappel er A, King AA, Perry BD, W andeler Al (1992) Pathogenicity of SAD rabies vaccine given orally in chacma baboons (Papio ursinus). Vet. Rec .. 18:55

9. Black JG, Lawson KF (1980) The safety and efficacy ofimmunizing foxes (Vulpes vulpes) using a bait containg attenuated rabies virus vaccine. Can. J. Comp. Med., 44: 169- 175
10. Blancou J, Kieny MP, Lathe R, Lecocq JP, Pastoret PP, Soulebot JP, Desmettre P (1986) Oral vaccination of the fox against rabies using a live recombinant vaccinia virus. Nature, 322:373 -375
11. Blancou J, Aubert MFA (1992) Vaccinia vectored rabies vaccine . In: Wildlife Rabies Control (eds. Bögel K, Meslin FX, Kaplan M) 13 - 104,Wells Medical Ltd. , Kent
12. Boulanger D, Brochier B, Crouch A, Bennett M, Gaskell RM, Baxby D, Pastoret PP (1995) Comparison of the susceptibility of the red fox (Vulpes vulpes) to a vaccinia-rabies recombinant virus and to cowpox virus. Vaccine, 13 : 215-219
13. Brochier B, Iokem A, Ginter A, Lejeune E, Costy F, Marchal A, Preharpre D, Couvreur JM, Dufey J, Kalpers J, Leonard M, Bauduin B, Desmecht M, Schneider LG, Pastoret PP (1987) First rabies vaccination campaign of foxes by the oral route in Belgium. Controls of efficacy and innocuity in foxes (Vulpes vulpes). Ann. Med. Vet. , 131 : 463-472
14. Brochier MB, Thomas I, Iokem A, Ginter A, Kalpers J, Paquot A, Costy F, Pastoret PP (1988) A field trial in Belgium to control fox rabies by iınmunisation. Vet. Rec., 123:618-622
15. Brusman HH, Linhart SB, Balser DS (1968) The technique for producing antifertility fallows baits for predatory mammals. J . Wilcll. Manage .. 32: 183-184
16. Bunn TO (1988) Vaccines and vaccination of doınestic aniınals . In: Rabies (eds. Campbell JB, Charlton KM) 323-334. Kluwer Academic Publishers, Bostan
17. Chappius G (1992) The rabies-vaccine recombinant: from the canception to the applications. In: Wildlife Rabies Control (eds. Bögel K, Meslin FX. Kaplan M) 141. Wells Medical Ltd., Kent
18. Charlton KM, Artois M, Prevec L, Campbell JB, Casey GA, W andeler Al, Armstrong J (1992) Oral rabies vaccination of skunks and foxes with a recombinant human adenavirus vaccine. Arch. Virol. . 123 : 169-l79 Debbie JG, Abelseth MK, Baer GM (1972) The use of c oınınercially available vaccines for the oral vaccination of foxes against rabies . Am. J. Epidem. , 96 : 231-235
19. Ewald D (1993) Pravalenz von Echinococcus multilocularis in der Nord- , üst- und Südschweiz sowie im Fürstentum Liechtenstein . Dissertation, University of Zurich.
20. Fesseler M, Müller B, Eckert J (19911) Vergleich geographisc her Verbreitung und regionaler Haufigkeit von Echinococcus multilocularis und Towllut in Mitteleuropa. Tierarztl. Umschau, 46:287-292
21. Follmann EH, Savarie PJ, Ritter DG, Baer GM (1987) Plasma marking of aretic foxes with ionphenoxic acid. J. Wildl. Dis .. 23:709-712
22. Fox JL (1990) Rab i es vaccine field test undertaken. Features , 56:579-583
23. Frost JW, Wachendörfer G, Gutman B, Dingeldein W, Schneider LG (1985) Erste Erfahrungen mit der or alen Immunisierung von Füchsen gegen Tollwut in Hessen. Berl. Münch. Tierarztl. Wschr .. 98:279-281
24. Goretzki J (1995) Opportunist und Gewinner. Unsere jagcl . 2:9-10
25. Goretzki J, Alırens M, Stubbe C, Tottewitz F, Sparing H, Gleich E ( 1997) Zur Ökologie des Rotfuchses (Vulpes vulpes L. 1 758)auf der Insel Rügen: Ergebnisse des Jungfuchsfanges und der Markierung. Beitrege zur Jagd- und Wildforschung. 22: 187-200
26. Gschwender P, Holzhofer F, Mürke H, Schuster P, Böhme H (1996) Einsatz des vollautomatischen Impfköderabwurfsystems SURVlS. Aınttier~irztl. Dienst Lebensmittelkontrolle, 111 :254-258
27. Haflinger U, Bichsel P, Wandeler A, Steck F (ı982l Zur oralen lMmunisicrung von Füchsen gegen Tollwut: Stabilisierung und 1\:öclerapplikation des Impfvirus. Zbl. Vet. Med B., 28:604-618 29 - Harris S, Rainer JMV ( 1 986a) Urban fox (Vulpes vulpes} population estimates and habitat requirements in several British cities . J. Animal Ecol. , 55:575-591
28. Harris S, Rainer JMV ( 1986b) Models for predicting urban fox (Vulpes vnlpes} numbers in British cities anel their application for rabies control. J . Aniın Ecol.. 55:593-601
29. Harris S, Rainer JMV (1986c) A dicriminant analysis of the current distribution of urban foxes (Vulpes vulpes) in Britain. J. Anim Ecol.. 55:605-611
30. Henning K, Czerny CP, Meyer H, Müller T, Kramer M (1995l A sero-epicleıniological survey for orthopox virus in the reel fox (Vulpes vulpesl. Vet. Microbiol. . 43:251-259
31. Johnston DH, Joachim DG, Bachmann P, Kardon KV, Stewart RFA, Dix LM, Strickland NA, Watt FO (1987) Aging furbearers using tooth structure anel biomarkers. In: Wild furbearer management anel conservation in North America (eds . Novak MJ, Baker JA, Obbard ME, Malloch B) 228-243. Ontario Trappers Association North Bay. Ontario
32. Johnston DH, Voigt DR, Maclnnes CD, Bachmann P, Lawson KF, Rupprecht CE (1988) An aerial b aiting system for the clistribu tion of a tlenuated or recombinant rabies vaccines for foxes, raccoons, anel skuııks. Rev. infect. Dis., 10:660-664
33. Kappeler A (1991) Die orale Immunisierung von Füchsen gegen Tollwut in eler Schweiz. Dissertation. University of Bern
34. Kappeler A (1992) Manual bait distribution in oral vaccination campaigns in Europe. In: Wildlife Rabies Control (eds. Bögel K. Meslin FX. Kaplan M) 155-159, Wells Medical Ltd .. Kent
35. Kappeler A, Wandeler Al, Capt S (1988) Ten years of rabies control by oral vaccination offoxes in Switzerland. In: Agriculture: vaccina!ion lo control rabies in foxes. EUR1 1439, 55-60. Commisian of the European Communities. Brussels
36. Kayserlinck v M, Thoms B, Körfer KH (1993) Kein akuter Anlass zur Besorgnis. Nieders. Jager. 38:749-751
37. Kieny MP, Lathe R, Drillien R, Spehner D, Skory S, Schmitt D, Wiktor TJ, Koprowski H, Lecocq JP (1984) Expressian of rabies virus glycoprotein from a recombinant vaccinia virus . Nature. 3 12:163-166
38. Kissling R, Gram G (1992) Orale Immunisierung von Füchsen gegen Tollwut in Österreich im Zeitraum von 1986 - 1991. Wien. Tierarztl. Mschr.. 79:333-344
39. Lafay F J, Benejean C, Tuffereau C, Flamand A, Coulon P (1994) Vaccincıtion against rabies: construction anel characterization or SAG2. a double avirulent clerivative of SAD Bern. Vaccine. 12 :317-320
40. Larson GE, Savarie PJ, Okuno I (1981) Iophenoxic acid and mirex for marking wild. bait-consuming animals. J. Wildl. Manage .. 45:1073-1077
41. Lawson KF, Black JG, Charlton KM, Johnston DH, Rhodes AJ (1987) Safety anel immunogenicity of a vaccine bait containing ERA strain of attenuatecl rabies virus. Can. J. Vet. Res .. 5 1:460-464
42. Lewis JC ( 1963) U se of poison baits to control rabies in Tennessee wildlife. Public Health Report. 83:69-74
43. Linhart SB ( 1964) Acceptance by wild foxes of certain baits for administrating antifertility agents . N. Y. Fish Game J .. ll :69-77
44. Linhart SB, Kennelly JJ (1967) Fluorescent bone labeling of coyotes with demethylchlor-tetracycline. J. Wild!. Manage., 31 :317-321
45. Maclnnes CD (1987) Rabies. In: Wild furbearer management and conservation in North America (eds. Novak MJ. Baker JA. Obbard ME,Malloch B) 910-929 . Ontario Trappers Association North Bay. Ontario
46. Maclnnes CD (1988) Control of Wildlife Rabies: the Americas. ln: Rabies (eds . Campbell JB. Charlton KM) 382-405. Kluwer Academic Publishers. Bostan
47. Maclnnes CD, Bachmann P, Pond BA, Fielding CA, Nunan CP, Ayers NR, Voigt DR, Lawson KF, Tinline RL (1992) Design considerations for large -scale aerial distribution of rabies vaccine-baits in Ontario. In: Wildlife Rabies Control (eds . Bögel K, Meslin FX. Kaplan M). 160- 167. Wells Medical Ltd., Kent
48. Masson E, Aubert MFA, Barrat J, Vuillaume P (1996) Comparison of the efficacy of the antirabies vaccines used for foxes in France. Vet. Res .. 27:255-266
49. Müller Th (1994) Epidemiologisclıe Un tersuch un gen zur Wirkung ausgewahlter Einflussfaktoren bei eler oralen Immunisierung der Füchse gegen Tollwut. Dissertation. University of Leipzig
50. Müller Th, Stöhr K, Loepelmann H, Neubert A, Schuster P, Karge E ( 1993a) Testung eines neuen Köders für die orale Immunisierung des Rotfuchses (Vulpes vulpes) gegen Tollwut. Berl. Münch. Tierarztl. Wschr.. 106:41-46
51. Müller T, Stöhr K, Teufert J, Stöhr P (1993b) Erfahrungen mit der Flugzeugbeköderung von Ködern zur oralen Immunisierung der Füchse gegen Tollwut in Ostdeutschland. Dtsch. Tierarztl. Wschr., 100:203-207
52. Müller T, Schlüter H, Kautzsch S (1995) Zur Wechselwirkung von araler Tollwutimmunisierung und Fuchspopulationsdynamik. Tierarztl. Umschau, 50:743-747
53. Müller T, Henning K, Kramer M, Czerny C-P, Meyer H, Ziedler K ( 1996) Seroprevalence of orthopoxvirus specific an tibodies in red foxes (Vulpes vulpes) in the federal state Brandenburg, Germany. J. Wildl. Dis. , 32:348-353
54. Müller WW ( 1997) Where do we stand with oral vaccination of foxes against rabies in Europe? Arch. Viral.. 13:83-94
55. Newmark P ( 1988) New vaccine and inititiative mean enel. of rabies in sight for Europe. Nature, 336:4.16
56. Oleyar CM, Macinnes BS (1974) Field evaluation of diathylstilbestrol for supressing reproduction in foxes . J. Wildl. Manage .. 38: 101- 106
57. Ondrejka R, Durove A, Svrcek S , Benisek Z, Sülova J (1997) Isolation and identification of Lyssa virus strains from tl1e area of oral antirabies vaccination in Slovakia. Vet. Med.Czech., 42:57-60
58. Paquot A, Brochier I, Pastaret PP (1988) Campagnes de vaccination antirabique du renard roux (Vulpes vulpes) menees en Belgique: mise en evielence de lingestion dappats vaccinaux par le cerf rouge (Cervus elaphus). le chevreuil (Capreolus capreolus) et le sanglier (Sus scrofa) . Ann. Med. Vet .. 132:697-702
59. Pastaret PP, Blancou J, Wolff F (1987) International rabies vaccination campaign of foxes by the oral route in Luxembourg. Ann Med. Vet.. 131:441-447
60. Pastaret PP, Brochier B, Languet B, Thomas I, Paquot A, Bauduin B, Kieny MP, Lecocq JP, De Bruyn J, Costy F, Antoine H, Desmettre P (1988) First field trial of fox vaccination against rabies us ing a vaccinia-rabies recombinant virus. Vet. Rec .. 123:481 -483
61. RBE (1989) New areas of Oral Fox Vaccination in Europe. Rabies Bulletin Europe, 13(3) :11-13
62. Ruatti A, Ponzanelli M, Allegretti M, Mengon F, Costanzi C (1988) L'esperienza Haliana nel controllo eleila rabbia. I Lavora operativo. Parasitologia 30: 19-28
63. Rupprecht CE, Kieny MP (1988) Development of a vaccinia-rabies glycoprotein recombinant virus vaccine. In: Rabies (eds. Campbell JB . Charlton KM) 335-364. Kluwer Academic Publishers. Bostan 66- Rupprecht CE, Hanlon CA, Cummins LB, Koprowski H (1992) Primate respanses to a vaccinia-rabies glycoprotein recombinant virus vaccine. Vaccine, 10:368-374
64. Schmid E (1988) Erfahrungen mit der oralen Immunisierung von Füchsen gegen Tollwut in Vorarlberg. Wien. tierarztl. Mschr., 9:338-340
65. Schloss vA (1997) Dar s tellung der Tollwutsituation in NordrheinWestfalen 1985 - 1995; Auftreten und Bekampfungsstrategie. Tierarztl. Umschau, 52:540-564
66. Schlüter H, Müller T (1995) Tollwutbekampfung in Deutschland. Ergebnisse und Schussfolgerungen aus über 10 jahriger Bekampfung. Tierarztl. Umschau. 50:7 48-758
67. Schneider LG (1984) Feldversuch zur oralen Immunisierung von Füchsen gegen die Tollwut in der Bundesrepublik Deutschland. Vakzineentwicklung, Planung und Durchführung der Impfaktion. bisherige Ergebnisse. 25-53. Kongressbericht der Tagung der FG Tierseuchenrecht - DVG. Giessen
68. Schneider LG (1990) Der Einfluss der oralen Immunisierung der Füchse auf die Epidemiologie der Tollwut. In: Fuchs-Symposium, Koblenz. 2-3 . Marz 1990 (eds. Commichau C, Sprankel H) 145-164. Verlag J. Neumann-Neudamm. Melsungen.
69. Schneider LG, Cox JH (1983) Ein Feldversuch zur oralen Immunisierung von Füchsen gegen die Tollwut in der Bundesrepublik Deutschland. I. Unschadlichkeit, Wirksaınkeit und Stabilitat der Vakzine SAD B19. Tierarztl. Umschau. 38:315-324
70. Schneider LG, Wachendörfer G, Schmittdiel E, Cox JH (1983) E in Feldversuch zur oral en Immunisierung von Füchsen ge gen die Tollwut in der Bundesrepublik Deutschland. II. Plannung. Durchführung und Auswertung des Feldveruchs. Tierarztl. Umschau, 38:476-480
71. Schn~ider LG, Cox JH, Müller WW (1987) Der Feldversuch zur oralen Immunisierung von Füchsen gegen die Tollwut in der BRD - Eine Zwischenbilanz. Tierarztl. Umschau, 42: 184- 198
72. Schott E, Müller B (1989) Zum Vorkommen von Echinococcus multilocularis beim Rotfuchs im Regierungsbezirk Tübingen. Tierarztl. Umschau, 44:367-370
73. Selhorst T, Schlüter H (1997) Cost-benefit analysis of the oral immuniiation strategy for the control in fox populations. Epidemiol. Sante. Anim., 3ı/32: 10.20 . 1-10 . 20 . 3
74. Sinnecker H, Apitzsch L, Berndt D, Selırader C, Gogolin J, Egert J (1990) Die Entwicklung des Tollwutlebendiınpfvirus SAD/Potsdam 5188 zur oral en Fuchsimpfung sowie seine Charakterisierung am Mausmodel. Mh. Vet. Med .. 45:77-78
75. Steck F, Hatlinger U, Stocker C, Wandeler A (1978) Oral immunization of foxes against rabies. Experienta, 34: 1662
76. Steck F, W andeler A, Bichsel P, Capt S, Schneider L (1982) Oral immunisation of foxes against rabies. Zbl. Vet. Med. B .. 29:372-396
77. Stöhr K, Karge E, Gadt H, Kokles R, Ehrentraut W, Witt W, Fink HG (1990a) Orale Immunisierung freilebender Füchse gegen Tollwut Vorbereitung und Durchfühnmg der ersten Feldversuche in den ostdeutschen Bundeslandern. Mh. Vet. Med .. 45:782-786
78. Stöhr K, Karge E, Loepelmann F, Loepelmann H, Gebauer R, Dedek J, Hahn J ( 1990b) Die Enh:vicklung des Impfköders für die orale Immunisierung freilebender Füchse gegen Tollwut. Mh. Vet. Med .. 45:165-169
79. Stöhr K, Stöhr P, Müller T (1994) Orale Fuchsimpfung gegen Tollwut Ergebnisse und Erfahrungen aus den ostdeutschen Bundeslandern. Tierarztl. Umschau. 49:203-211
80. Stöhr K, Meslin FX ( 1996) Progress and setbacks in the oral immunisation of foxes against rabies in Europe. Vet. Rec., 139:32-35
81. Thomas I, Brochier B, Languet B, Blancou J, Perharpre D, Kieny MP, Desmettre P, Chappuis G, Pastoret PP (1990) Primary multiplication site of the vaccinia-rabies glycoprotein recombinant virus administered to foxes by the oral route. J. Gen. Viral., 71:3742
82. Trewhella WJ, Harris S, Smith GC (1991) A field trial evaluating bait uptake by an urban fox population. J. Appl. Ecol., 28:454-466
83. Voigt D, Tinline R, Broekhoven LA (1985) A spatial simulation model for rabies control. In: Population dynamics of rabies in wildlife (ed. Bacon PJJ 3 11-349. Academic Press. London 87 V os A ( 1990) Untersuchungen zur Entwicklung der Fuchspopulation nach erfolgreichem Abschluss der oralen lmmunisierungen gegen Tollwut. In: Fuchs-Symposium, Koblenz. 2-3. Marz 1990 (eds. Commichau C, Sprankel H) 165-170. Verlag J. NeumannNeudamm. Melsungen.
84. Wachendörfer G, Frost JW, Gutmann B, Hofmann J, Schneider LG, Eskens U, Dingeldein W (1986) Erfahrungen mit der oralen lmmunisierung von Füchsen in Hessen. Tierarztl. Praxis 14: 185-196
85. Wachendörfer G, Frost JW ( 1992) Epidemiology of red fax rabies. İn: Wildlife Rabies Control (eds. Bögel K, Meslin FX. Kaplan MJ 19-31. Wells Medical Ltd .. Kent
86. Wandeler AI (1988) Control of Wildlife Rabies. In: Rabies (eds. Campbell JB. Charlton KM) 365-380. Kluwer Academic Publishers. Bostan
87. Wandeler AI ( 1992a) New attenuated virus es anel li ve veetareel rabies vaccines. In: Wilcllife Rabies Control (ecls. Bögel K. Meslin FX, Kaplcu1 MJ 125-126. Wells Medical Ltd. , Kent
88. Wandeler AI (1992b) Safety aspects for man. domestic cu1imals and other non-target species: attenuated rabies vaccines. In: Wildlife Rabies Control (eds. Bögel K. Meslin FX, Kaplan M) 123-124. Wells Medical Ltd .. Kent
89. Wandeler AI, Pfotenhauer P, Stocker C (1975) Über die Verwendung von Ködern zu biologischen Untersuchungen an Füchsen. Rev. Suisse Zool.. 82:335-348
90. Westerling B ( 1989) A field trial on oral imununization of raccoon dogs and foxes against rabies in Finland 1988 - 1989. Rabies Bulletin Europe. 13(2):9-12
91. WHO ( 1982) Report of consultations on oral anel enteric mass iınmunization of wildlife. 20-22 September 1982. WHO/Rab.Res./82. World Health Organization, Geneva
92. WHO (1989) Report of WHO consultation on requirements and criteria for field trials on oral rabies vaccination of dogs and wild carnivores. Geneva 1-2 March 1989. WHO/Rab.Res./89.32. World Health Organization , Geneva
93. WHO ( 1990a) Report of the s eminar on wildlife rabies co n tr ol. Geneva 2-5 July. WHO/CDS/VPH/90.93. World Health Organization , Geneva
94. WHO (1990b) Report of a WHO/NVI workshop on aretic rabies . Uppsala, Sweden, 24-27 April 1990. World Health Organization, Geneva 99 - WHO (l990c) Report of WHO 1 APHIS consultation on baits anel baiting delivery systems for oral immunization of wildlife against rabies. Fort Collins, Colorado. 10-12 July 1990. WHO/Rab.Res/90.36. World Health Organization, Geneva
95. WHO ( 1990d) Guiding principles for the post vaccination surveillance of wildlife rabies in Europe, Geneva. 2-5 July 1990. WHO/CDS/VPH/90.93 World Health Organization, Geneva
96. WHO ( 1990e) Alveolar echinococcosis. Week1y Epidemiol. Report. 65. 37-44
97. Winkler WG (1992) A review of the development of the oral vaccination technique for immunizing wildlife against rabies. In: Wildlife Rabies Control (eds. Bögel K. Meslin FX. Kaplan M) 19-31. Wells Medical Ltd .. Kent